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Risk adjusted benchmarking of abdominoperineal excision for rectal adenocarcinoma in the context of the Belgian PROCARE improvement project

Freddy Penninckx, Steffen Fieuws, Koen Beirens, Pieter Demetter, Wim Ceelen UGent, Alex Kartheuser, Gaetan Molle, Jean Van de Stadt, Koen Vindevoghel and Elizabeth Van Eycken (2013) GUT. 62(7). p.1005-1011
abstract
Objective: The abdominoperineal excision (APE) rate, a quality of care indicator in rectal cancer surgery, has been criticised if not adjusted for confounding factors. This study evaluates variability in APE rate between centres participating in PROCARE, a Belgian improvement initiative, before and after risk adjustment. It also explores the effect of merging the Hartmann resections (HR) rate with that of APE on benchmarking. Design: Data of 3197 patients who underwent elective radical resection for invasive rectal adenocarcinoma up to 15 cm were registered between January 2006 and March 2011 by 59 centres, each with at least 10 patients in the registry. Variability of APE or merged APE/HR rates between centres was analysed before and after adjustment for gender, age, ASA score (3 or more), tumour level (rectal third), depth of tumour invasion (cT4) and preoperative incontinence. Results: The overall APE rate was 21.1% (95% CI 19.7 to 22.5%). Significant variation of the APE rate was observed before and after risk adjustment (p<0.0001). For cancers in the lower rectal third, the overall APE rate increased to 45.8% (95% CI 43.1 to 48.5%). Also, variation between centres increased. Risk adjustment influenced the identification of outliers. HR was performed in only 2.6% of patients. However, merging of risk adjusted APE and HR rates identified other centres with outlying definitive colostomy rates than APE rate alone. Conclusion: Significant variation of the APE rate was observed. Adjustment for confounding factors as well as merging HR with APE rates were found to be important for the assessment of performances.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
POPULATION, THERAPY, RESECTION, RATES, PROCEDURE VOLUME, CANCER SURGERY, QUALITY-ASSURANCE
journal title
GUT
Gut
volume
62
issue
7
pages
1005 - 1011
Web of Science type
Article
Web of Science id
000319975900010
JCR category
GASTROENTEROLOGY & HEPATOLOGY
JCR impact factor
13.319 (2013)
JCR rank
2/75 (2013)
JCR quartile
1 (2013)
ISSN
0017-5749
DOI
10.1136/gutjnl-2011-301941
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5709681
handle
http://hdl.handle.net/1854/LU-5709681
date created
2014-09-24 16:26:50
date last changed
2016-12-19 15:46:44
@article{5709681,
  abstract     = {Objective: The abdominoperineal excision (APE) rate, a quality of care indicator in rectal cancer surgery, has been criticised if not adjusted for confounding factors. This study evaluates variability in APE rate between centres participating in PROCARE, a Belgian improvement initiative, before and after risk adjustment. It also explores the effect of merging the Hartmann resections (HR) rate with that of APE on benchmarking. 
Design: Data of 3197 patients who underwent elective radical resection for invasive rectal adenocarcinoma up to 15 cm were registered between January 2006 and March 2011 by 59 centres, each with at least 10 patients in the registry. Variability of APE or merged APE/HR rates between centres was analysed before and after adjustment for gender, age, ASA score (3 or more), tumour level (rectal third), depth of tumour invasion (cT4) and preoperative incontinence. 
Results: The overall APE rate was 21.1\% (95\% CI 19.7 to 22.5\%). Significant variation of the APE rate was observed before and after risk adjustment (p{\textlangle}0.0001). For cancers in the lower rectal third, the overall APE rate increased to 45.8\% (95\% CI 43.1 to 48.5\%). Also, variation between centres increased. Risk adjustment influenced the identification of outliers. HR was performed in only 2.6\% of patients. However, merging of risk adjusted APE and HR rates identified other centres with outlying definitive colostomy rates than APE rate alone. 
Conclusion: Significant variation of the APE rate was observed. Adjustment for confounding factors as well as merging HR with APE rates were found to be important for the assessment of performances.},
  author       = {Penninckx, Freddy and Fieuws, Steffen and Beirens, Koen and Demetter, Pieter and Ceelen, Wim and Kartheuser, Alex and Molle, Gaetan and Van de Stadt, Jean and Vindevoghel, Koen and Van Eycken, Elizabeth},
  issn         = {0017-5749},
  journal      = {GUT},
  keyword      = {POPULATION,THERAPY,RESECTION,RATES,PROCEDURE VOLUME,CANCER SURGERY,QUALITY-ASSURANCE},
  language     = {eng},
  number       = {7},
  pages        = {1005--1011},
  title        = {Risk adjusted benchmarking of abdominoperineal excision for rectal adenocarcinoma in the context of the Belgian PROCARE improvement project},
  url          = {http://dx.doi.org/10.1136/gutjnl-2011-301941},
  volume       = {62},
  year         = {2013},
}

Chicago
Penninckx, Freddy, Steffen Fieuws, Koen Beirens, Pieter Demetter, Wim Ceelen, Alex Kartheuser, Gaetan Molle, Jean Van de Stadt, Koen Vindevoghel, and Elizabeth Van Eycken. 2013. “Risk Adjusted Benchmarking of Abdominoperineal Excision for Rectal Adenocarcinoma in the Context of the Belgian PROCARE Improvement Project.” GUT 62 (7): 1005–1011.
APA
Penninckx, Freddy, Fieuws, S., Beirens, K., Demetter, P., Ceelen, W., Kartheuser, A., Molle, G., et al. (2013). Risk adjusted benchmarking of abdominoperineal excision for rectal adenocarcinoma in the context of the Belgian PROCARE improvement project. GUT, 62(7), 1005–1011.
Vancouver
1.
Penninckx F, Fieuws S, Beirens K, Demetter P, Ceelen W, Kartheuser A, et al. Risk adjusted benchmarking of abdominoperineal excision for rectal adenocarcinoma in the context of the Belgian PROCARE improvement project. GUT. 2013;62(7):1005–11.
MLA
Penninckx, Freddy, Steffen Fieuws, Koen Beirens, et al. “Risk Adjusted Benchmarking of Abdominoperineal Excision for Rectal Adenocarcinoma in the Context of the Belgian PROCARE Improvement Project.” GUT 62.7 (2013): 1005–1011. Print.