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Mitochondrial perturbation negatively affects auxin signaling

Pavel Kerchev, Inge De Clercq UGent, Jordi Denecker, Per Mühlenbock UGent, Robert Kumpf, Long Nguyen UGent, Dominique Audenaert UGent, Wim Dejonghe and Frank Van Breusegem UGent (2014) MOLECULAR PLANT. 7(7). p.1138-1150
abstract
Mitochondria are crucial players in the signaling and metabolic homeostasis of the plant cell. The molecular components that orchestrate the underlying processes, however, are largely unknown. Using a chemical biology approach, we exploited the responsiveness of Arabidopsis UDP-glucosyltransferase-encoding UGT74E2 towards mitochondrial perturbation in order to look for novel mechanisms regulating mitochondria-to-nucleus communication. The most potent inducers of UGT74E2 shared a (2-furyl) acrylate (FAA) substructure that negatively affected mitochondrial function and was identified before as an auxin transcriptional inhibitor. Based on these premises, we demonstrated that perturbed mitochondria negatively affect the auxin signaling machinery. Moreover, chemical perturbation of polar auxin transport and auxin biosynthesis was sufficient to induce mitochondrial retrograde markers and their transcript abundance was constitutively elevated in the absence of the auxin transcriptional activators ARF7 and ARF19.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ELECTRON-TRANSPORT, NAC TRANSCRIPTION FACTOR, ALTERNATIVE OXIDASE, OXIDATIVE STRESS, RETROGRADE REGULATION, LEAF MITOCHONDRIA, ARABIDOPSIS-THALIANA, PLANTS, OSMOTIC-STRESS, retrograde communication, mitochondrial perturbation, GENE-EXPRESSION, auxin signaling
journal title
MOLECULAR PLANT
Mol. Plant.
volume
7
issue
7
pages
1138 - 1150
Web of Science type
Article
Web of Science id
000339947600006
JCR category
PLANT SCIENCES
JCR impact factor
6.337 (2014)
JCR rank
9/204 (2014)
JCR quartile
1 (2014)
ISSN
1674-2052
DOI
10.1093/mp/ssu071
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5709527
handle
http://hdl.handle.net/1854/LU-5709527
date created
2014-09-24 15:57:19
date last changed
2016-12-19 15:38:58
@article{5709527,
  abstract     = {Mitochondria are crucial players in the signaling and metabolic homeostasis of the plant cell. The molecular components that orchestrate the underlying processes, however, are largely unknown. Using a chemical biology approach, we exploited the responsiveness of Arabidopsis UDP-glucosyltransferase-encoding UGT74E2 towards mitochondrial perturbation in order to look for novel mechanisms regulating mitochondria-to-nucleus communication. The most potent inducers of UGT74E2 shared a (2-furyl) acrylate (FAA) substructure that negatively affected mitochondrial function and was identified before as an auxin transcriptional inhibitor. Based on these premises, we demonstrated that perturbed mitochondria negatively affect the auxin signaling machinery. Moreover, chemical perturbation of polar auxin transport and auxin biosynthesis was sufficient to induce mitochondrial retrograde markers and their transcript abundance was constitutively elevated in the absence of the auxin transcriptional activators ARF7 and ARF19.},
  author       = {Kerchev, Pavel and De Clercq, Inge and Denecker, Jordi and M{\"u}hlenbock, Per and Kumpf, Robert and Nguyen, Long and Audenaert, Dominique and Dejonghe, Wim and Van Breusegem, Frank},
  issn         = {1674-2052},
  journal      = {MOLECULAR PLANT},
  keyword      = {ELECTRON-TRANSPORT,NAC TRANSCRIPTION FACTOR,ALTERNATIVE OXIDASE,OXIDATIVE STRESS,RETROGRADE REGULATION,LEAF MITOCHONDRIA,ARABIDOPSIS-THALIANA,PLANTS,OSMOTIC-STRESS,retrograde communication,mitochondrial perturbation,GENE-EXPRESSION,auxin signaling},
  language     = {eng},
  number       = {7},
  pages        = {1138--1150},
  title        = {Mitochondrial perturbation negatively affects auxin signaling},
  url          = {http://dx.doi.org/10.1093/mp/ssu071},
  volume       = {7},
  year         = {2014},
}

Chicago
Kerchev, Pavel, Inge De Clercq, Jordi Denecker, Per Mühlenbock, Robert Kumpf, Long Nguyen, Dominique Audenaert, Wim Dejonghe, and Frank Van Breusegem. 2014. “Mitochondrial Perturbation Negatively Affects Auxin Signaling.” Molecular Plant 7 (7): 1138–1150.
APA
Kerchev, P., De Clercq, I., Denecker, J., Mühlenbock, P., Kumpf, R., Nguyen, L., Audenaert, D., et al. (2014). Mitochondrial perturbation negatively affects auxin signaling. MOLECULAR PLANT, 7(7), 1138–1150.
Vancouver
1.
Kerchev P, De Clercq I, Denecker J, Mühlenbock P, Kumpf R, Nguyen L, et al. Mitochondrial perturbation negatively affects auxin signaling. MOLECULAR PLANT. 2014;7(7):1138–50.
MLA
Kerchev, Pavel, Inge De Clercq, Jordi Denecker, et al. “Mitochondrial Perturbation Negatively Affects Auxin Signaling.” MOLECULAR PLANT 7.7 (2014): 1138–1150. Print.