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Small size ionic heterogeneities in the human heart can attract rotors

Arne Defauw (UGent) , Nele Vandersickel (UGent) , Peter Dawyndt (UGent) and Alexander Panfilov (UGent)
Author
Organization
Project
HPC-UGent: the central High Performance Computing infrastructure of Ghent University
Project
Bioinformatics: from nucleotids to networks (N2N)
Abstract
Rotors occurring in the heart underlie the mechanisms of cardiac arrhythmias. Answering the question whether or not the location of rotors is related to local properties of cardiac tissue has important practical applications. This is because ablation of rotors has been shown to be an effective way to fight cardiac arrhythmias. In this study, we investigate, in silico, the dynamics of rotors in 2D and in an anatomical model of human ventricles using a TNNP model for ventricular cells. We study the effect of small size ionic heterogeneities, similar to those measured experimentally. It is shown that such heterogeneities can not only anchor, but can also attract rotors rotating at a substantial distance from the heterogeneity. This attraction distance depends on the extent of the heterogeneities and can be as large as 5-6 cm in realistic conditions. We conclude that small size ionic heterogeneities can be preferred localization points for rotors, and discuss their possible mechanism and value for applications.
Keywords
Cardiac arrhythmias, heterogeneity, computer modeling, BETA-ADRENERGIC AGONISTS, HUMAN VENTRICULAR TISSUE, LONG-QT SYNDROME, ISOLATED CARDIAC-MUSCLE, ATRIAL-FIBRILLATION, TRANSMURAL DISPERSION, SPIRAL BREAKUP, REENTRY, rotors, MODEL, reentry, FOCAL IMPULSE

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Citation

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Chicago
Defauw, Arne, Nele Vandersickel, Peter Dawyndt, and Alexander Panfilov. 2014. “Small Size Ionic Heterogeneities in the Human Heart Can Attract Rotors.” American Journal of Physiology-heart and Circulatory Physiology 307 (10): H1456–H1468.
APA
Defauw, A., Vandersickel, N., Dawyndt, P., & Panfilov, A. (2014). Small size ionic heterogeneities in the human heart can attract rotors. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 307(10), H1456–H1468.
Vancouver
1.
Defauw A, Vandersickel N, Dawyndt P, Panfilov A. Small size ionic heterogeneities in the human heart can attract rotors. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2014;307(10):H1456–H1468.
MLA
Defauw, Arne, Nele Vandersickel, Peter Dawyndt, et al. “Small Size Ionic Heterogeneities in the Human Heart Can Attract Rotors.” AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 307.10 (2014): H1456–H1468. Print.
@article{5707492,
  abstract     = {Rotors occurring in the heart underlie the mechanisms of cardiac arrhythmias. Answering the question whether or not the location of rotors is related to local properties of cardiac tissue has important practical applications. This is because ablation of rotors has been shown to be an effective way to fight cardiac arrhythmias. In this study, we investigate, in silico, the dynamics of rotors in 2D and in an anatomical model of human ventricles using a TNNP model for ventricular cells. We study the effect of small size ionic heterogeneities, similar to those measured experimentally. It is shown that such heterogeneities can not only anchor, but can also attract rotors rotating at a substantial distance from the heterogeneity. This attraction distance depends on the extent of the heterogeneities and can be as large as 5-6 cm in realistic conditions. We conclude that small size ionic heterogeneities can be preferred localization points for rotors, and discuss their possible mechanism and value for applications.},
  author       = {Defauw, Arne and Vandersickel, Nele and Dawyndt, Peter and Panfilov, Alexander},
  issn         = {0363-6135},
  journal      = {AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY},
  keyword      = {Cardiac arrhythmias,heterogeneity,computer modeling,BETA-ADRENERGIC AGONISTS,HUMAN VENTRICULAR TISSUE,LONG-QT SYNDROME,ISOLATED CARDIAC-MUSCLE,ATRIAL-FIBRILLATION,TRANSMURAL DISPERSION,SPIRAL BREAKUP,REENTRY,rotors,MODEL,reentry,FOCAL IMPULSE},
  language     = {eng},
  number       = {10},
  pages        = {H1456--H1468},
  title        = {Small size ionic heterogeneities in the human heart can attract rotors},
  url          = {http://dx.doi.org/10.1152/ajpheart.00410.2014},
  volume       = {307},
  year         = {2014},
}

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