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MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien Mets (UGent) , Joni Van der Meulen (UGent) , Gert Van Peer (UGent) , Michael Boice, Pieter Mestdagh (UGent) , Inge Van de Walle (UGent) , Tim Lammens (UGent) , Steven Goossens (UGent) , Barbara De Moerloose (UGent) , Yves Benoit (UGent) , et al.
(2015) LEUKEMIA. 29(4). p.798-806
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Abstract
The MYB oncogene is a leucine zipper transcription factor essential for normal and malignant hematopoiesis. In T-cell acute lymphoblastic leukemia (T-ALL), elevated MYB levels can arise directly through T-cell receptor-mediated MYB translocations, genomic MYB duplications or enhanced TAL1 complex binding at the MYB locus or indirectly through the TAL1/miR-223/FBXW7 regulatory axis. In this study, we used an unbiased MYB 3 ' untranslated region-microRNA (miRNA) library screen and identified 33 putative MYB-targeting miRNAs. Subsequently, transcriptome data from two independent T-ALL cohorts and different subsets of normal T-cells were used to select miRNAs with relevance in the context of normal and malignant T-cell transformation. Hereby, miR-193b-3p was identified as a novel bona fide tumor-suppressor miRNA that targets MYB during malignant T-cell transformation thereby offering an entry point for efficient MYB targeting-oriented therapies for human T-ALL.
Keywords
HEMATOPOIETIC-CELLS, C-MYB, TAL1 COMPLEX, CANCER-CELLS, GENES, EXPRESSION, DIFFERENTIATION, MICRORNAS, THERAPEUTICS, MUTATIONS

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Chicago
Mets, Evelien, Joni Van der Meulen, Gert Van Peer, Michael Boice, Pieter Mestdagh, Inge Van de Walle, Tim Lammens, et al. 2015. “MicroRNA-193b-3p Acts as a Tumor Suppressor by Targeting the MYB Oncogene in T-cell Acute Lymphoblastic Leukemia.” Leukemia 29 (4): 798–806.
APA
Mets, E., Van der Meulen, J., Van Peer, G., Boice, M., Mestdagh, P., Van de Walle, I., Lammens, T., et al. (2015). MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia. LEUKEMIA, 29(4), 798–806.
Vancouver
1.
Mets E, Van der Meulen J, Van Peer G, Boice M, Mestdagh P, Van de Walle I, et al. MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia. LEUKEMIA. 2015;29(4):798–806.
MLA
Mets, Evelien, Joni Van der Meulen, Gert Van Peer, et al. “MicroRNA-193b-3p Acts as a Tumor Suppressor by Targeting the MYB Oncogene in T-cell Acute Lymphoblastic Leukemia.” LEUKEMIA 29.4 (2015): 798–806. Print.
@article{5707391,
  abstract     = {The MYB oncogene is a leucine zipper transcription factor essential for normal and malignant hematopoiesis. In T-cell acute lymphoblastic leukemia (T-ALL), elevated MYB levels can arise directly through T-cell receptor-mediated MYB translocations, genomic MYB duplications or enhanced TAL1 complex binding at the MYB locus or indirectly through the TAL1/miR-223/FBXW7 regulatory axis. In this study, we used an unbiased MYB 3 ' untranslated region-microRNA (miRNA) library screen and identified 33 putative MYB-targeting miRNAs. Subsequently, transcriptome data from two independent T-ALL cohorts and different subsets of normal T-cells were used to select miRNAs with relevance in the context of normal and malignant T-cell transformation. Hereby, miR-193b-3p was identified as a novel bona fide tumor-suppressor miRNA that targets MYB during malignant T-cell transformation thereby offering an entry point for efficient MYB targeting-oriented therapies for human T-ALL.},
  author       = {Mets, Evelien and Van der Meulen, Joni and Van Peer, Gert and Boice, Michael and Mestdagh, Pieter and Van de Walle, Inge and Lammens, Tim and Goossens, Steven and De Moerloose, Barbara and Benoit, Yves and Van Roy, Nadine and Clappier, Emmanuelle and Poppe, Bruce and Vandesompele, Jo and Wendel, Hans-Guido and Taghon, Tom and Rondou, Pieter and Soulier, Jean and Van Vlierberghe, Pieter and Speleman, Franki},
  issn         = {0887-6924},
  journal      = {LEUKEMIA},
  language     = {eng},
  number       = {4},
  pages        = {798--806},
  title        = {MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.1038/leu.2014.276},
  volume       = {29},
  year         = {2015},
}

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