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Transcranial magnetic stimulation dissociates prefrontal and parietal contributions to task preparation

Paul Simon Muhle-Karbe (UGent) , Michael Andres (UGent) and Marcel Brass (UGent)
(2014) JOURNAL OF NEUROSCIENCE. 34(37). p.12481-12489
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The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Cognitive control is thought to rely upon a set of distributed brain regions within frontoparietal cortex, but the functional contributions of these regions remain elusive. Here, we investigated the disruptive effects of transcranial magnetic stimulation (TMS) over the human prefrontal and parietal cortices in task preparation at different abstraction levels. While participants completed a task-switching paradigm that assessed the reconfiguration of task goals and response sets independently, TMS was applied over the left inferior frontal junction (IFJ) and over the left intraparietal sulcus (IPS) during task preparation. In Experiment 1, TMS over the IFJ caused interference with the updating of task goals, while leaving the updating of response sets unaffected. In Experiment 2, TMS over the IPS created the opposite pattern of results, perturbing only the ability to update response sets, but not task goals. Experiment 3 furthermore revealed that TMS over the IPS interfered with task goal updating when the pulses are delivered at a later point in time during preparation. This dissociation of abstract and action-related components not only reveals distinct cognitive control processes during task preparation, but also sheds new light on how prefrontal and parietal areas might work in concert to support flexible and goal-oriented control of behavior.
Keywords
transcranial magnetic stimulation, task preparation, prefrontal cortex, parietal cortex, cognitive control, ORGANIZATION, CORTEX, MOTOR PLANS, COMBINED FMRI, EXECUTIVE CONTROL, WORKING-MEMORY, COGNITIVE CONTROL, TOP-DOWN MODULATION, ANTERIOR INTRAPARIETAL SULCUS, INFERIOR FRONTAL JUNCTION

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Citation

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Chicago
Muhle-Karbe, Paul Simon, Michael Andres, and Marcel Brass. 2014. “Transcranial Magnetic Stimulation Dissociates Prefrontal and Parietal Contributions to Task Preparation.” Journal of Neuroscience 34 (37): 12481–12489.
APA
Muhle-Karbe, Paul Simon, Andres, M., & Brass, M. (2014). Transcranial magnetic stimulation dissociates prefrontal and parietal contributions to task preparation. JOURNAL OF NEUROSCIENCE, 34(37), 12481–12489.
Vancouver
1.
Muhle-Karbe PS, Andres M, Brass M. Transcranial magnetic stimulation dissociates prefrontal and parietal contributions to task preparation. JOURNAL OF NEUROSCIENCE. 2014;34(37):12481–9.
MLA
Muhle-Karbe, Paul Simon, Michael Andres, and Marcel Brass. “Transcranial Magnetic Stimulation Dissociates Prefrontal and Parietal Contributions to Task Preparation.” JOURNAL OF NEUROSCIENCE 34.37 (2014): 12481–12489. Print.
@article{5707109,
  abstract     = {Cognitive control is thought to rely upon a set of distributed brain regions within frontoparietal cortex, but the functional contributions
of these regions remain elusive. Here, we investigated the disruptive effects of transcranial magnetic stimulation (TMS) over the human
prefrontal and parietal cortices in task preparation at different abstraction levels. While participants completed a task-switching paradigm
that assessed the reconfiguration of task goals and response sets independently, TMS was applied over the left inferior frontal
junction (IFJ) and over the left intraparietal sulcus (IPS) during task preparation. In Experiment 1, TMS over the IFJ caused interference
with the updating of task goals, while leaving the updating of response sets unaffected. In Experiment 2, TMS over the IPS created the
opposite pattern of results, perturbing only the ability to update response sets, but not task goals. Experiment 3 furthermore revealed that
TMS over the IPS interfered with task goal updating when the pulses are delivered at a later point in time during preparation. This
dissociation of abstract and action-related components not only reveals distinct cognitive control processes during task preparation, but
also sheds new light on how prefrontal and parietal areas might work in concert to support flexible and goal-oriented control of behavior.},
  author       = {Muhle-Karbe, Paul Simon and Andres, Michael and Brass, Marcel},
  issn         = {0270-6474},
  journal      = {JOURNAL OF NEUROSCIENCE},
  keywords     = {transcranial magnetic stimulation,task preparation,prefrontal cortex,parietal cortex,cognitive control,ORGANIZATION,CORTEX,MOTOR PLANS,COMBINED FMRI,EXECUTIVE CONTROL,WORKING-MEMORY,COGNITIVE CONTROL,TOP-DOWN MODULATION,ANTERIOR INTRAPARIETAL SULCUS,INFERIOR FRONTAL JUNCTION},
  language     = {eng},
  number       = {37},
  pages        = {12481--12489},
  title        = {Transcranial magnetic stimulation dissociates prefrontal and parietal contributions to task preparation},
  url          = {http://dx.doi.org/10.1523/JNEUROSCI.4931-13.2014},
  volume       = {34},
  year         = {2014},
}

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