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Cystatin C: a new renal marker and its potential use in small animal medicine

Liesbeth Ghys (UGent) , Dominique Paepe (UGent) , Pascale Smets (UGent) , Hervé Lefebvre, Joris Delanghe (UGent) and Sylvie Daminet (UGent)
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Abstract
The occurrence of chronic kidney disease is underestimated in both human and veterinary medicine. Glomerular filtration rate (GFR) is considered the gold standard for evaluating kidney function. However, GFR assessment is time-consuming and labor-intensive and therefore not routinely used in practice. The commonly used indirect GFR markers, serum creatinine (sCr) and urea, are not sufficiently sensitive or specific to detect early renal dysfunction. Serum cystatin C (sCysC), a proteinase inhibitor, has most of the properties required for an endogenous GFR marker. In human medicine, numerous studies have evaluated its potential use as a GFR marker in several populations. In veterinary medicine, this marker is gaining interest. The measurement is easy, which makes it an interesting parameter for clinical use. This review summarizes current knowledge about cystatin C (CysC) in humans, dogs, and cats, including its history, assays, relationship with GFR, and biological and clinical variations in both human and veterinary medicine.
Keywords
PLASMA CREATININE, SERUM CREATININE, THYROID-DYSFUNCTION, ENDOGENOUS CREATININE CLEARANCE, CHRONIC KIDNEY-DISEASE, ENHANCED TURBIDIMETRIC IMMUNOASSAY, HUMAN GAMMA-TRACE, MOLECULAR-WEIGHT PROTEINURIA, TYPE-2 DIABETES-MELLITUS, GLOMERULAR-FILTRATION-RATE, Dog, Cat, Glomerular filtration rate, Renal diseases, Human

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Chicago
Ghys, Liesbeth, Dominique Paepe, Pascale Smets, Hervé Lefebvre, Joris Delanghe, and Sylvie Daminet. 2014. “Cystatin C: a New Renal Marker and Its Potential Use in Small Animal Medicine.” Journal of Veterinary Internal Medicine 28 (4): 1152–1164.
APA
Ghys, L., Paepe, D., Smets, P., Lefebvre, H., Delanghe, J., & Daminet, S. (2014). Cystatin C: a new renal marker and its potential use in small animal medicine. JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(4), 1152–1164.
Vancouver
1.
Ghys L, Paepe D, Smets P, Lefebvre H, Delanghe J, Daminet S. Cystatin C: a new renal marker and its potential use in small animal medicine. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2014;28(4):1152–64.
MLA
Ghys, Liesbeth, Dominique Paepe, Pascale Smets, et al. “Cystatin C: a New Renal Marker and Its Potential Use in Small Animal Medicine.” JOURNAL OF VETERINARY INTERNAL MEDICINE 28.4 (2014): 1152–1164. Print.
@article{5700055,
  abstract     = {The occurrence of chronic kidney disease is underestimated in both human and veterinary medicine. Glomerular filtration rate (GFR) is considered the gold standard for evaluating kidney function. However, GFR assessment is time-consuming and labor-intensive and therefore not routinely used in practice. The commonly used indirect GFR markers, serum creatinine (sCr) and urea, are not sufficiently sensitive or specific to detect early renal dysfunction. Serum cystatin C (sCysC), a proteinase inhibitor, has most of the properties required for an endogenous GFR marker. In human medicine, numerous studies have evaluated its potential use as a GFR marker in several populations. In veterinary medicine, this marker is gaining interest. The measurement is easy, which makes it an interesting parameter for clinical use. This review summarizes current knowledge about cystatin C (CysC) in humans, dogs, and cats, including its history, assays, relationship with GFR, and biological and clinical variations in both human and veterinary medicine.},
  author       = {Ghys, Liesbeth and Paepe, Dominique and Smets, Pascale and Lefebvre, Herv{\'e} and Delanghe, Joris and Daminet, Sylvie},
  issn         = {1939-1676},
  journal      = {JOURNAL OF VETERINARY INTERNAL MEDICINE},
  language     = {eng},
  number       = {4},
  pages        = {1152--1164},
  title        = {Cystatin C: a new renal marker and its potential use in small animal medicine},
  url          = {http://dx.doi.org/10.1111/jvim.12366},
  volume       = {28},
  year         = {2014},
}

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