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Hepatitis mouse models : from acute-to-chronic autoimmune hepatitis

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Abstract
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease associated with interface hepatitis, raised plasma liver enzymes, the presence of autoantibodies and regulatory T-cell (Tregs) dysfunction. The clinical course is heterogeneous, manifested by a fulminant or indolent course. Although genetic predisposition is well accepted, the combination with currently undefined environmental factors is crucial for the development of the disease. Progress in the development of reliable animal models provides added understanding of the pathophysiology of AIH, and these will be very useful in evaluating potential therapeutics. It appears that artificially breaking tolerance in the liver is easy. However, maintaining this state of tolerance breakdown, to get chronic hepatitis, is difficult because liver immune homeostasis is strongly regulated by several immune response inhibitory mechanisms. For example, Tregs are crucial regulators in acute and chronic hepatitis, and C57BL/6 mice are most prone to experimental AIH. Immunization of C57BL/6 mice with liver (AIH) autoantigens (CYP2D6/FTCD or IL-4R) and the disturbance of liver regulatory mechanism(s), leading to experimental AIH, are likely to be most representative of human AIH pathology.
Keywords
formiminotransferase cyclodeaminase, :CYP2D6, liver tolerance, mouse models Th17, tregs, SINUSOIDAL ENDOTHELIAL-CELLS, TUMOR-NECROSIS-FACTOR, AUTOANTIGEN CYTOCHROME-P450 2D6, ORGAN-SPECIFIC AUTOIMMUNITY, MURINE MODEL, TRANSGENIC MICE, CONCANAVALIN-A, LIVER-INJURY, DENDRITIC CELLS, IFN-GAMMA

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Chicago
Yüksel, Muhammed, Debby Laukens, Femke Heindrickx, Hans Van Vlierberghe, Anja Geerts, F Susan Wong, Li Wen, and Isabelle Colle. 2014. “Hepatitis Mouse Models : from Acute-to-chronic Autoimmune Hepatitis.” International Journal of Experimental Pathology 95 (5): 309–320.
APA
Yüksel, M., Laukens, D., Heindrickx, F., Van Vlierberghe, H., Geerts, A., Wong, F. S., Wen, L., et al. (2014). Hepatitis mouse models : from acute-to-chronic autoimmune hepatitis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 95(5), 309–320.
Vancouver
1.
Yüksel M, Laukens D, Heindrickx F, Van Vlierberghe H, Geerts A, Wong FS, et al. Hepatitis mouse models : from acute-to-chronic autoimmune hepatitis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. 2014;95(5):309–20.
MLA
Yüksel, Muhammed, Debby Laukens, Femke Heindrickx, et al. “Hepatitis Mouse Models : from Acute-to-chronic Autoimmune Hepatitis.” INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 95.5 (2014): 309–320. Print.
@article{5687424,
  abstract     = {Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease associated with interface hepatitis, raised plasma liver enzymes, the presence of autoantibodies and regulatory T-cell (Tregs) dysfunction. The clinical course is heterogeneous, manifested by a fulminant or indolent course. Although genetic predisposition is well accepted, the combination with currently undefined environmental factors is crucial for the development of the disease. Progress in the development of reliable animal models provides added understanding of the pathophysiology of AIH, and these will be very useful in evaluating potential therapeutics. It appears that artificially breaking tolerance in the liver is easy. However, maintaining this state of tolerance breakdown, to get chronic hepatitis, is difficult because liver immune homeostasis is strongly regulated by several immune response inhibitory mechanisms. For example, Tregs are crucial regulators in acute and chronic hepatitis, and C57BL/6 mice are most prone to experimental AIH. Immunization of C57BL/6 mice with liver (AIH) autoantigens (CYP2D6/FTCD or IL-4R) and the disturbance of liver regulatory mechanism(s), leading to experimental AIH, are likely to be most representative of human AIH pathology.},
  author       = {Yüksel, Muhammed and Laukens, Debby and Heindrickx, Femke and Van Vlierberghe, Hans and Geerts, Anja and Wong, F Susan and Wen, Li and Colle, Isabelle},
  issn         = {0959-9673},
  journal      = {INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY},
  keywords     = {formiminotransferase cyclodeaminase,:CYP2D6,liver tolerance,mouse models Th17,tregs,SINUSOIDAL ENDOTHELIAL-CELLS,TUMOR-NECROSIS-FACTOR,AUTOANTIGEN CYTOCHROME-P450 2D6,ORGAN-SPECIFIC AUTOIMMUNITY,MURINE MODEL,TRANSGENIC MICE,CONCANAVALIN-A,LIVER-INJURY,DENDRITIC CELLS,IFN-GAMMA},
  language     = {eng},
  number       = {5},
  pages        = {309--320},
  title        = {Hepatitis mouse models : from acute-to-chronic autoimmune hepatitis},
  url          = {http://dx.doi.org/10.1111/iep.12090},
  volume       = {95},
  year         = {2014},
}

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