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An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure

Jan Cosyn (UGent) , Véronique Christiaens (UGent) , VINCENT KONINGSVELD (UGent) , Paul Coucke (UGent) , Peter De Coster (UGent) , Anne De Paepe (UGent) and Hugo De Bruyn (UGent)
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Abstract
Background: The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce. Purpose: The objective of this case-control study was to explore the impact of IL-1A (−889), IL-1B (−511), and IL-1B (+3,954) gene polymorphisms on early implant failure in Caucasians. Materials and Methods: Between September 2004 and August 2007, 461 patients were treated with dental implants at the University Hospital in Ghent, Belgium. Fourteen subjects of this patient group who had experienced one or more early implant failures (within 6 months from implant installation) were recruited as “cases.” Fourteen “controls,” matched in terms of age, gender, and smoking habits, with only surviving implants, were selected from the same patient group. Allele and genotype analysis was performed on the basis of a blood sample by Sanger sequencing of polymerase chain reaction products containing the IL-1A (−889), IL-1B (−511), and IL-1B (+3,954) gene polymorphisms. Results: A significant impact of the IL-1A (−889) T allele (p = .039) and the IL-1B (+3,954) T allele (p = .003) on early implant failure was demonstrated (odds ratios = 3.9 and 15.0, respectively). In addition, the genotypic distribution differed significantly between cases and controls for IL-1B (+3,954) (p = .015). Conclusions: The IL-1B (+3,954) gene polymorphism seems to affect osseointegration. Additional case-control studies in larger patient groups are needed to confirm this observation.
Keywords
SURVIVAL, SMOKING, EXPRESSION, POPULATION, PATHOGENESIS, GENOTYPE, ASSOCIATION, INTERLEUKIN-1-BETA, survival rate, polymorphism, interleukin, osseointegration, implant failure, implant survival, case-control study

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Chicago
Cosyn, Jan, Véronique Christiaens, VINCENT KONINGSVELD, Paul Coucke, Peter De Coster, Anne De Paepe, and Hugo De Bruyn. 2016. “An Exploratory Case-control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure.” Clinical Implant Dentistry and Related Research 18 (2): 234–240.
APA
Cosyn, J., Christiaens, V., KONINGSVELD, V., Coucke, P., De Coster, P., De Paepe, A., & De Bruyn, H. (2016). An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 18(2), 234–240.
Vancouver
1.
Cosyn J, Christiaens V, KONINGSVELD V, Coucke P, De Coster P, De Paepe A, et al. An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH. 2016;18(2):234–40.
MLA
Cosyn, Jan, Véronique Christiaens, VINCENT KONINGSVELD, et al. “An Exploratory Case-control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH 18.2 (2016): 234–240. Print.
@article{5687187,
  abstract     = {Background: The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce.
Purpose: The objective of this case-control study was to explore the impact of IL-1A (\ensuremath{-}889), IL-1B (\ensuremath{-}511), and IL-1B (+3,954) gene polymorphisms on early implant failure in Caucasians.
Materials and Methods: Between September 2004 and August 2007, 461 patients were treated with dental implants at the University Hospital in Ghent, Belgium. Fourteen subjects of this patient group who had experienced one or more early implant failures (within 6 months from implant installation) were recruited as {\textquotedblleft}cases.{\textquotedblright} Fourteen {\textquotedblleft}controls,{\textquotedblright} matched in terms of age, gender, and smoking habits, with only surviving implants, were selected from the same patient group. Allele and genotype analysis was performed on the basis of a blood sample by Sanger sequencing of polymerase chain reaction products containing the IL-1A (\ensuremath{-}889), IL-1B (\ensuremath{-}511), and IL-1B (+3,954) gene polymorphisms.
Results: A significant impact of the IL-1A (\ensuremath{-}889) T allele (p = .039) and the IL-1B (+3,954) T allele (p = .003) on early implant failure was demonstrated (odds ratios = 3.9 and 15.0, respectively). In addition, the genotypic distribution differed significantly between cases and controls for IL-1B (+3,954) (p = .015).
Conclusions: The IL-1B (+3,954) gene polymorphism seems to affect osseointegration. Additional case-control studies in larger patient groups are needed to confirm this observation.},
  author       = {Cosyn, Jan and Christiaens, V{\'e}ronique and KONINGSVELD, VINCENT and Coucke, Paul and De Coster, Peter and De Paepe, Anne and De Bruyn, Hugo},
  issn         = {1523-0899},
  journal      = {CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH},
  keyword      = {SURVIVAL,SMOKING,EXPRESSION,POPULATION,PATHOGENESIS,GENOTYPE,ASSOCIATION,INTERLEUKIN-1-BETA,survival rate,polymorphism,interleukin,osseointegration,implant failure,implant survival,case-control study},
  language     = {eng},
  number       = {2},
  pages        = {234--240},
  title        = {An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure},
  url          = {http://dx.doi.org/10.1111/cid.12237},
  volume       = {18},
  year         = {2016},
}

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