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miRBase Tracker : keeping track of microRNA annotation changes

Gert Van Peer (UGent) , Steve Lefever (UGent) , Jasper Anckaert (UGent) , Anneleen Beckers (UGent) , Ali Rihani (UGent) , Alan Van Goethem (UGent) , Pieter-Jan Volders (UGent) , Fjoralba Zeka (UGent) , Maté Ongenaert (UGent) , Pieter Mestdagh (UGent) , et al.
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Abstract
Since 2002, information on individual microRNAs (miRNAs), such as reference names and sequences, has been stored in miRBase, the reference database for miRNA annota- tion. As a result of progressive insights into the miRNome and its complexity, miRBase underwent addition and deletion of miRNA records, changes in annotated miRNA se- quences and adoption of more complex naming schemes over time. Unfortunately, miRBase does not allow straightforward assessment of these ongoing miRNA annota- tion changes, which has resulted in substantial ambiguity regarding miRNA identity and sequence in public literature, in target prediction databases and in content on various commercially available analytical platforms. As a result, correct interpretation, compari- son and integration of miRNA study results are compromised, which we demonstrate here by assessing the impact of ignoring sequence annotation changes. To address this problem, we developed miRBase Tracker (www.mirbasetracker.org), an easy-to-use on- line database that keeps track of all historical and current miRNA annotation present in the miRBase database. Three basic functionalities allow researchers to keep their miRNA annotation up-to-date, reannotate analytical miRNA platforms and link published results with outdated annotation to the latest miRBase release. We expect miRBase Tracker to increase the transparency and annotation accuracy in the field of miRNA research. Database URL: www.mirbasetracker.org
Keywords
TARGETS

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MLA
Van Peer, Gert, Steve Lefever, Jasper Anckaert, et al. “miRBase Tracker : Keeping Track of microRNA Annotation Changes.” DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2014): n. pag. Print.
APA
Van Peer, Gert, Lefever, S., Anckaert, J., Beckers, A., Rihani, A., Van Goethem, A., Volders, P.-J., et al. (2014). miRBase Tracker : keeping track of microRNA annotation changes. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.
Chicago author-date
Van Peer, Gert, Steve Lefever, Jasper Anckaert, Anneleen Beckers, Ali Rihani, Alan Van Goethem, Pieter-Jan Volders, et al. 2014. “miRBase Tracker : Keeping Track of microRNA Annotation Changes.” Database-the Journal of Biological Databases and Curation.
Chicago author-date (all authors)
Van Peer, Gert, Steve Lefever, Jasper Anckaert, Anneleen Beckers, Ali Rihani, Alan Van Goethem, Pieter-Jan Volders, Fjoralba Zeka, Maté Ongenaert, Pieter Mestdagh, and Jo Vandesompele. 2014. “miRBase Tracker : Keeping Track of microRNA Annotation Changes.” Database-the Journal of Biological Databases and Curation.
Vancouver
1.
Van Peer G, Lefever S, Anckaert J, Beckers A, Rihani A, Van Goethem A, et al. miRBase Tracker : keeping track of microRNA annotation changes. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION. 2014;
IEEE
[1]
G. Van Peer et al., “miRBase Tracker : keeping track of microRNA annotation changes,” DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2014.
@article{5684895,
  abstract     = {{Since 2002, information on individual microRNAs (miRNAs), such as reference names and sequences, has been stored in miRBase, the reference database for miRNA annota- tion. As a result of progressive insights into the miRNome and its complexity, miRBase underwent addition and deletion of miRNA records, changes in annotated miRNA se- quences and adoption of more complex naming schemes over time. Unfortunately, miRBase does not allow straightforward assessment of these ongoing miRNA annota- tion changes, which has resulted in substantial ambiguity regarding miRNA identity and sequence in public literature, in target prediction databases and in content on various commercially available analytical platforms. As a result, correct interpretation, compari- son and integration of miRNA study results are compromised, which we demonstrate here by assessing the impact of ignoring sequence annotation changes. To address this problem, we developed miRBase Tracker (www.mirbasetracker.org), an easy-to-use on- line database that keeps track of all historical and current miRNA annotation present in the miRBase database. Three basic functionalities allow researchers to keep their miRNA annotation up-to-date, reannotate analytical miRNA platforms and link published results with outdated annotation to the latest miRBase release. We expect miRBase Tracker to increase the transparency and annotation accuracy in the field of miRNA research. Database URL: www.mirbasetracker.org}},
  articleno    = {{bau080}},
  author       = {{Van Peer, Gert and Lefever, Steve and Anckaert, Jasper and Beckers, Anneleen and Rihani, Ali and Van Goethem, Alan and Volders, Pieter-Jan and Zeka, Fjoralba and Ongenaert, Maté and Mestdagh, Pieter and Vandesompele, Jo}},
  issn         = {{1758-0463}},
  journal      = {{DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION}},
  keywords     = {{TARGETS}},
  language     = {{eng}},
  pages        = {{8}},
  title        = {{miRBase Tracker : keeping track of microRNA annotation changes}},
  url          = {{http://dx.doi.org/10.1093/database/bau080}},
  year         = {{2014}},
}

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