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Abstract
The influenza pH1N1 virus caused a global flu pandemic in 2009 and continues manifestation as a seasonal virus. Better understanding of the virus-host cell interaction could result in development of better prevention and treatment options. Here we show that the Akt inhibitor MK2206 blocks influenza pH1N1 virus infection in vitro. In particular, at noncytotoxic concentrations, MK2206 alters Akt signaling and inhibits endocytic uptake of the virus. Interestingly, MK2206 is unable to inhibit H3N2, H7N9, and H5N1 viruses, indicating that pH1N1 evolved specific requirements for efficient infection. Thus, Akt signaling could be exploited further for development of better therapeutics against pH1N1 virus.
Keywords
A VIRUS, SALIPHENYLHALAMIDE, SUPPRESSION, INSULIN, TARGET, APOPTOSIS, ANTIVIRALS, PHOSPHORYLATION, CELLS, SIGNALING PATHWAY

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Citation

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MLA
Denisova, Oxana V, Sandra Söderholm, Salla Virtanen, et al. “Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus Infection in Vitro.” ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 58.7 (2014): 3689–3696. Print.
APA
Denisova, O. V., Söderholm, S., Virtanen, S., Von Schantz, C., Bychkov, D., Vashchinkina, E., Desloovere, J., et al. (2014). Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(7), 3689–3696.
Chicago author-date
Denisova, Oxana V, Sandra Söderholm, Salla Virtanen, Carina Von Schantz, Dmitrii Bychkov, Elena Vashchinkina, Jens Desloovere, et al. 2014. “Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus Infection in Vitro.” Antimicrobial Agents and Chemotherapy 58 (7): 3689–3696.
Chicago author-date (all authors)
Denisova, Oxana V, Sandra Söderholm, Salla Virtanen, Carina Von Schantz, Dmitrii Bychkov, Elena Vashchinkina, Jens Desloovere, Janne Tynell, Niina Ikonen, Linda L Theisen, Tuula A Nyman, Sampsa Matikainen, Olli Kallioniemi, Ilkka Julkunen, Claude P Muller, Xavier Saelens, Vladislav V Verkhusha, and Denis E Kainov. 2014. “Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus Infection in Vitro.” Antimicrobial Agents and Chemotherapy 58 (7): 3689–3696.
Vancouver
1.
Denisova OV, Söderholm S, Virtanen S, Von Schantz C, Bychkov D, Vashchinkina E, et al. Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2014;58(7):3689–96.
IEEE
[1]
O. V. Denisova et al., “Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro,” ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 58, no. 7, pp. 3689–3696, 2014.
@article{5674489,
  abstract     = {The influenza pH1N1 virus caused a global flu pandemic in 2009 and continues manifestation as a seasonal virus. Better understanding of the virus-host cell interaction could result in development of better prevention and treatment options. Here we show that the Akt inhibitor MK2206 blocks influenza pH1N1 virus infection in vitro. In particular, at noncytotoxic concentrations, MK2206 alters Akt signaling and inhibits endocytic uptake of the virus. Interestingly, MK2206 is unable to inhibit H3N2, H7N9, and H5N1 viruses, indicating that pH1N1 evolved specific requirements for efficient infection. Thus, Akt signaling could be exploited further for development of better therapeutics against pH1N1 virus.},
  author       = {Denisova, Oxana V and Söderholm, Sandra and Virtanen, Salla and Von Schantz, Carina and Bychkov, Dmitrii and Vashchinkina, Elena and Desloovere, Jens and Tynell, Janne and Ikonen, Niina and Theisen, Linda L and Nyman, Tuula A and Matikainen, Sampsa and Kallioniemi, Olli and Julkunen, Ilkka and Muller, Claude P and Saelens, Xavier and Verkhusha, Vladislav V and Kainov, Denis E},
  issn         = {0066-4804},
  journal      = {ANTIMICROBIAL AGENTS AND CHEMOTHERAPY},
  keywords     = {A VIRUS,SALIPHENYLHALAMIDE,SUPPRESSION,INSULIN,TARGET,APOPTOSIS,ANTIVIRALS,PHOSPHORYLATION,CELLS,SIGNALING PATHWAY},
  language     = {eng},
  number       = {7},
  pages        = {3689--3696},
  title        = {Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro},
  url          = {http://dx.doi.org/10.1128/AAC.02798-13},
  volume       = {58},
  year         = {2014},
}

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