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Brain connectivity and postural control in young traumatic brain injury patients: a diffusion MRI based network analysis

(2012) NEUROIMAGE-CLINICAL. 1(1). p.106-115
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Abstract
Our previous research on traumatic brain injury (TBI) patients has shown a strong relationship between specific white matter (WM) diffusion properties and motor deficits. The potential impact of TBI-related changes in network organization of the associated WM structural network on motor performance, however, remains largely unknown. Here, we used diffusion tensor imaging (DTI) based fiber tractography to reconstruct the human brain WM networks of 12 TBI and 17 control participants, followed by a graph theoretical analysis. A force platform was used to measure changes in body posture under conditions of compromised proprioceptive and/or visual feedback. Findings revealed that compared with controls, TBI patients showed higher betweenness centrality and normalized path length, and lower values of local efficiency, implying altered network organization. These results were not merely a consequence of differences in number of connections. In particular, TBI patients displayed reduced structural connectivity in frontal, parieto-premotor, visual, subcortical, and temporal areas. In addition, the decreased connectivity degree was significantly associated with poorer balance performance. We conclude that analyzing the structural brain networks with a graph theoretical approach provides new insights into motor control deficits following brain injury.
Keywords
Structural network, Postural control, Diffusion tensor imaging, Motor control, Traumatic brain injury, Graph theoretical network analysis

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Chicago
Caeyenberghs, Karen, A Leemans, C De Decker, M Heitger, D Drijkoningen, Catharine Vander Linden, S Sunaerts, and S Swinnen. 2012. “Brain Connectivity and Postural Control in Young Traumatic Brain Injury Patients: a Diffusion MRI Based Network Analysis.” Neuroimage-clinical 1 (1): 106–115.
APA
Caeyenberghs, Karen, Leemans, A., De Decker, C., Heitger, M., Drijkoningen, D., Vander Linden, C., Sunaerts, S., et al. (2012). Brain connectivity and postural control in young traumatic brain injury patients: a diffusion MRI based network analysis. NEUROIMAGE-CLINICAL, 1(1), 106–115.
Vancouver
1.
Caeyenberghs K, Leemans A, De Decker C, Heitger M, Drijkoningen D, Vander Linden C, et al. Brain connectivity and postural control in young traumatic brain injury patients: a diffusion MRI based network analysis. NEUROIMAGE-CLINICAL. 2012;1(1):106–15.
MLA
Caeyenberghs, Karen, A Leemans, C De Decker, et al. “Brain Connectivity and Postural Control in Young Traumatic Brain Injury Patients: a Diffusion MRI Based Network Analysis.” NEUROIMAGE-CLINICAL 1.1 (2012): 106–115. Print.
@article{5672931,
  abstract     = {Our previous research on traumatic brain injury (TBI) patients has shown a strong relationship between specific white matter (WM) diffusion properties and motor deficits. The potential impact of TBI-related changes in network organization of the associated WM structural network on motor performance, however, remains largely unknown. Here, we used diffusion tensor imaging (DTI) based fiber tractography to reconstruct the human brain WM networks of 12 TBI and 17 control participants, followed by a graph theoretical analysis. A force platform was used to measure changes in body posture under conditions of compromised proprioceptive and/or visual feedback. Findings revealed that compared with controls, TBI patients showed higher betweenness centrality and normalized path length, and lower values of local efficiency, implying altered network organization. These results were not merely a consequence of differences in number of connections. In particular, TBI patients displayed reduced structural connectivity in frontal, parieto-premotor, visual, subcortical, and temporal areas. In addition, the decreased connectivity degree was significantly associated with poorer balance performance. We conclude that analyzing the structural brain networks with a graph theoretical approach provides new insights into motor control deficits following brain injury.},
  author       = {Caeyenberghs, Karen and Leemans, A and De Decker, C and Heitger, M and Drijkoningen, D and Vander Linden, Catharine and Sunaerts, S and Swinnen, S},
  issn         = {2213-1582},
  journal      = {NEUROIMAGE-CLINICAL},
  language     = {eng},
  number       = {1},
  pages        = {106--115},
  title        = {Brain connectivity and postural control in young traumatic brain injury patients: a diffusion MRI based network analysis},
  url          = {http://dx.doi.org/10.1016/j.nicl.2012.09.011},
  volume       = {1},
  year         = {2012},
}

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