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Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning

(2012) LEARNING & MEMORY. 19(8). p.351-357
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Organization
Abstract
The corpus callosum (CC) is the largest white matter tract in the brain. It enables interhemispheric communication, particularly with respect to bimanual coordination. Here, we use diffusion tensor imaging (DTI) in healthy humans to determine the extent to which structural organization of subregions within the CC would predict how well subjects learn a novel bimanual task. A single DTI scan was taken prior to training. Participants then practiced a bimanual visuomotor task over the course of 2 wk, consisting of multiple coordination patterns. Findings revealed that the predictive power of fractional anisotropy (FA) was a function of CC subregion and practice. That is, FA of the anterior CC, which projects to the prefrontal cortex, predicted bimanual learning rather than the middle CC regions, which connect primary motor cortex. This correlation was specific in that FA correlated significantly with performance of the most difficult frequency ratios tested and not the innately preferred, isochronous frequency ratio. Moreover, the effect was only evident after training and not at initiation of practice. This is the first DTI study in healthy adults which demonstrates that white matter organization of the interhemispheric connections between the prefrontal structures is strongly correlated with motor learning capability
Keywords
COORDINATION TASK, BRAIN ACTIVATION, MOVEMENTS, INTEGRITY, SKILL, AUTOMATICITY, ACQUISITION, MUTUAL INFORMATION, WHITE-MATTER MICROSTRUCTURE, MULTIPLE-SCLEROSIS PATIENTS

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MLA
Sisti, Helene M, Monique Geurts, Jolien Gooijers, et al. “Microstructural Organization of Corpus Callosum Projections to Prefrontal Cortex Predicts Bimanual Motor Learning.” LEARNING & MEMORY 19.8 (2012): 351–357. Print.
APA
Sisti, H. M., Geurts, M., Gooijers, J., Heitger, M., Caeyenberghs, K., Beets, I. A., Serbruyns, L., et al. (2012). Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning. LEARNING & MEMORY, 19(8), 351–357.
Chicago author-date
Sisti, Helene M, Monique Geurts, Jolien Gooijers, Marcus Heitger, Karen Caeyenberghs, Iseult AM Beets, Leen Serbruyns, Alexander Leemans, and Stephan P Swinnen. 2012. “Microstructural Organization of Corpus Callosum Projections to Prefrontal Cortex Predicts Bimanual Motor Learning.” Learning & Memory 19 (8): 351–357.
Chicago author-date (all authors)
Sisti, Helene M, Monique Geurts, Jolien Gooijers, Marcus Heitger, Karen Caeyenberghs, Iseult AM Beets, Leen Serbruyns, Alexander Leemans, and Stephan P Swinnen. 2012. “Microstructural Organization of Corpus Callosum Projections to Prefrontal Cortex Predicts Bimanual Motor Learning.” Learning & Memory 19 (8): 351–357.
Vancouver
1.
Sisti HM, Geurts M, Gooijers J, Heitger M, Caeyenberghs K, Beets IA, et al. Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning. LEARNING & MEMORY. 2012;19(8):351–7.
IEEE
[1]
H. M. Sisti et al., “Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning,” LEARNING & MEMORY, vol. 19, no. 8, pp. 351–357, 2012.
@article{5672755,
  abstract     = {The corpus callosum (CC) is the largest white matter tract in the brain. It enables interhemispheric communication, particularly with respect to bimanual coordination. Here, we use diffusion tensor imaging (DTI) in healthy humans to determine the extent to which structural organization of subregions within the CC would predict how well subjects learn a novel bimanual task. A single DTI scan was taken prior to training. Participants then practiced a bimanual visuomotor task over the course of 2 wk, consisting of multiple coordination patterns. Findings revealed that the predictive power of fractional anisotropy (FA) was a function of CC subregion and practice. That is, FA of the anterior CC, which projects to the prefrontal cortex, predicted bimanual learning rather than the middle CC regions, which connect primary motor cortex. This correlation was specific in that FA correlated significantly with performance of the most difficult frequency ratios tested and not the innately preferred, isochronous frequency ratio. Moreover, the effect was only evident after training and not at initiation of practice. This is the first DTI study in healthy adults which demonstrates that white matter organization of the interhemispheric connections between the prefrontal structures is strongly correlated with motor learning capability},
  author       = {Sisti, Helene M and Geurts, Monique and Gooijers, Jolien and Heitger, Marcus and Caeyenberghs, Karen and Beets, Iseult AM and Serbruyns, Leen and Leemans, Alexander and Swinnen, Stephan P},
  issn         = {1072-0502},
  journal      = {LEARNING & MEMORY},
  keywords     = {COORDINATION TASK,BRAIN ACTIVATION,MOVEMENTS,INTEGRITY,SKILL,AUTOMATICITY,ACQUISITION,MUTUAL INFORMATION,WHITE-MATTER MICROSTRUCTURE,MULTIPLE-SCLEROSIS PATIENTS},
  language     = {eng},
  number       = {8},
  pages        = {351--357},
  title        = {Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning},
  url          = {http://dx.doi.org/10.1101/lm.026534.112},
  volume       = {19},
  year         = {2012},
}

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