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Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry

(2014) JOURNAL OF EXPERIMENTAL MEDICINE. 211(6). p.1019-1025
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Abstract
There is currently no paradigm in immunology that enables an accurate prediction of how the immune system will respond to any given agent. Here we show that the immunological responses induced by members of a broad class of inorganic crystalline materials are controlled purely by their physicochemical properties in a highly predictable manner. We show that structurally and chemically homogeneous layered double hydroxides (LDHs) can elicit diverse human dendritic cell responses in vitro. Using a systems vaccinology approach, we find that every measured response can be modeled using a subset of just three physical and chemical properties for all compounds tested. This correlation can be reduced to a simple linear equation that enables the immunological responses stimulated by newly synthesized LDHs to be predicted in advance from these three parameters alone. We also show that mouse antigen-specific antibody responses in vivo and human macrophage responses in vitro are controlled by the same properties, suggesting they may control diverse responses at both individual component and global levels of immunity. This study demonstrates that immunity can be determined purely by chemistry and opens the possibility of rational manipulation of immunity for therapeutic purposes.
Keywords
ALUMINUM, ACTIVATION, NALP3 INFLAMMASOME, INFLAMMATORY DENDRITIC CELLS, MACROPHAGES, ADJUVANTS, RESPONSES, SILICA

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MLA
Williams, Gareth R., et al. “Immunity Induced by a Broad Class of Inorganic Crystalline Materials Is Directly Controlled by Their Chemistry.” JOURNAL OF EXPERIMENTAL MEDICINE, vol. 211, no. 6, 2014, pp. 1019–25, doi:10.1084/jem.20131768.
APA
Williams, G. R., Fierens, K., Preston, S. G., Lunn, D., Rysnik, O., De Prijck, S., … Austyn, J. M. (2014). Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry. JOURNAL OF EXPERIMENTAL MEDICINE, 211(6), 1019–1025. https://doi.org/10.1084/jem.20131768
Chicago author-date
Williams, Gareth R, Kaat Fierens, Stephen G Preston, Daniel Lunn, Oliwia Rysnik, Sofie De Prijck, Mirjam Kool, et al. 2014. “Immunity Induced by a Broad Class of Inorganic Crystalline Materials Is Directly Controlled by Their Chemistry.” JOURNAL OF EXPERIMENTAL MEDICINE 211 (6): 1019–25. https://doi.org/10.1084/jem.20131768.
Chicago author-date (all authors)
Williams, Gareth R, Kaat Fierens, Stephen G Preston, Daniel Lunn, Oliwia Rysnik, Sofie De Prijck, Mirjam Kool, Hannah C Buckley, Bart Lambrecht, Dermot O’Hare, and Jonathan M Austyn. 2014. “Immunity Induced by a Broad Class of Inorganic Crystalline Materials Is Directly Controlled by Their Chemistry.” JOURNAL OF EXPERIMENTAL MEDICINE 211 (6): 1019–1025. doi:10.1084/jem.20131768.
Vancouver
1.
Williams GR, Fierens K, Preston SG, Lunn D, Rysnik O, De Prijck S, et al. Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry. JOURNAL OF EXPERIMENTAL MEDICINE. 2014;211(6):1019–25.
IEEE
[1]
G. R. Williams et al., “Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry,” JOURNAL OF EXPERIMENTAL MEDICINE, vol. 211, no. 6, pp. 1019–1025, 2014.
@article{5662225,
  abstract     = {{There is currently no paradigm in immunology that enables an accurate prediction of how the immune system will respond to any given agent. Here we show that the immunological responses induced by members of a broad class of inorganic crystalline materials are controlled purely by their physicochemical properties in a highly predictable manner. We show that structurally and chemically homogeneous layered double hydroxides (LDHs) can elicit diverse human dendritic cell responses in vitro. Using a systems vaccinology approach, we find that every measured response can be modeled using a subset of just three physical and chemical properties for all compounds tested. This correlation can be reduced to a simple linear equation that enables the immunological responses stimulated by newly synthesized LDHs to be predicted in advance from these three parameters alone. We also show that mouse antigen-specific antibody responses in vivo and human macrophage responses in vitro are controlled by the same properties, suggesting they may control diverse responses at both individual component and global levels of immunity. This study demonstrates that immunity can be determined purely by chemistry and opens the possibility of rational manipulation of immunity for therapeutic purposes.}},
  author       = {{Williams, Gareth R and Fierens, Kaat and Preston, Stephen G and Lunn, Daniel and Rysnik, Oliwia and De Prijck, Sofie and Kool, Mirjam and Buckley, Hannah C and Lambrecht, Bart and O'Hare, Dermot and Austyn, Jonathan M}},
  issn         = {{0022-1007}},
  journal      = {{JOURNAL OF EXPERIMENTAL MEDICINE}},
  keywords     = {{ALUMINUM,ACTIVATION,NALP3 INFLAMMASOME,INFLAMMATORY DENDRITIC CELLS,MACROPHAGES,ADJUVANTS,RESPONSES,SILICA}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1019--1025}},
  title        = {{Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry}},
  url          = {{http://dx.doi.org/10.1084/jem.20131768}},
  volume       = {{211}},
  year         = {{2014}},
}

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