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Use of pluripotent stem cells for reproductive medicine: are we there yet?

Galbha Duggal (UGent) , Björn Heindryckx (UGent) , Tom Deroo (UGent) and Petra De Sutter (UGent)
(2014) VETERINARY QUARTERLY. 34(1). p.42-51
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Abstract
In recent years, pluripotent stem cells have demonstrated to be exciting tools to understand embryonic development, cell lineage specification, tissue generation and repair, and various other biological processes. In addition, the identification and isolation of germ line stem cells has given more insight into germ cell biology at the molecular level and into the underlying causes of infertility which was not possible earlier. The recent derivation of in vitro derived sperm and oocytes from pluripotent stem cells in the mouse model represents a major breakthrough in the field and substantiates the critical relevance of stem cells as a potential alternative resource for treating infertility. Although the past years have yielded compelling information in understanding germ cell development via in vitro stem cell assays, extended investigative research is necessary in order to derive fully functional artificial gametes' in a safe way for future therapeutic applications.
Keywords
EMBRYONIC-DEVELOPMENT, TRANSPLANTATION, DERIVATION, SOMATIC-CELLS, VIVO DIFFERENTIATION, ES CELLS, MOUSE TESTES, NUCLEAR TRANSFER, PRIMORDIAL GERM-CELLS, reproduction, IN-VITRO DIFFERENTIATION, infertility, artificial gametes, germ line stem cells, embryonic stem cells, pluripotent stem cells

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Citation

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Chicago
Duggal, Galbha, Björn Heindryckx, Tom Deroo, and Petra De Sutter. 2014. “Use of Pluripotent Stem Cells for Reproductive Medicine: Are We There Yet?” Veterinary Quarterly 34 (1): 42–51.
APA
Duggal, G., Heindryckx, B., Deroo, T., & De Sutter, P. (2014). Use of pluripotent stem cells for reproductive medicine: are we there yet? VETERINARY QUARTERLY, 34(1), 42–51.
Vancouver
1.
Duggal G, Heindryckx B, Deroo T, De Sutter P. Use of pluripotent stem cells for reproductive medicine: are we there yet? VETERINARY QUARTERLY. 2014;34(1):42–51.
MLA
Duggal, Galbha, Björn Heindryckx, Tom Deroo, et al. “Use of Pluripotent Stem Cells for Reproductive Medicine: Are We There Yet?” VETERINARY QUARTERLY 34.1 (2014): 42–51. Print.
@article{5662158,
  abstract     = {In recent years, pluripotent stem cells have demonstrated to be exciting tools to understand embryonic development, cell lineage specification, tissue generation and repair, and various other biological processes. In addition, the identification and isolation of germ line stem cells has given more insight into germ cell biology at the molecular level and into the underlying causes of infertility which was not possible earlier. The recent derivation of in vitro derived sperm and oocytes from pluripotent stem cells in the mouse model represents a major breakthrough in the field and substantiates the critical relevance of stem cells as a potential alternative resource for treating infertility. Although the past years have yielded compelling information in understanding germ cell development via in vitro stem cell assays, extended investigative research is necessary in order to derive fully functional artificial gametes' in a safe way for future therapeutic applications.},
  author       = {Duggal, Galbha and Heindryckx, Björn and Deroo, Tom and De Sutter, Petra},
  issn         = {0165-2176},
  journal      = {VETERINARY QUARTERLY},
  keywords     = {EMBRYONIC-DEVELOPMENT,TRANSPLANTATION,DERIVATION,SOMATIC-CELLS,VIVO DIFFERENTIATION,ES CELLS,MOUSE TESTES,NUCLEAR TRANSFER,PRIMORDIAL GERM-CELLS,reproduction,IN-VITRO DIFFERENTIATION,infertility,artificial gametes,germ line stem cells,embryonic stem cells,pluripotent stem cells},
  language     = {eng},
  number       = {1},
  pages        = {42--51},
  title        = {Use of pluripotent stem cells for reproductive medicine: are we there yet?},
  url          = {http://dx.doi.org/10.1080/01652176.2014.891061},
  volume       = {34},
  year         = {2014},
}

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