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Association between aflatoxin M₁ exposure through breast milk and growth impairment in infants from Northern Tanzania

(2014) WORLD MYCOTOXIN JOURNAL. 7(3). p.277-284
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Abstract
Infants breastfeeding from mothers consuming aflatoxin contaminated foods may be exposed to aflatoxin M1(AFM1), a metabolite of aflatoxin B1. This study estimated the association between AFM1 exposure levels and growth indicators, for infants under six months of age in Northern Tanzania. A total of 143 infants and their mothers were involved. Breast-milk samples, infants’ anthropometric data and 24hr dietary recall for mothers were taken at the 1st, 3rd and 5th months of children age. AFM1 contaminations in the samples were determined using HPLC. AFM1 exposure by an infant was estimated by multiplying contamination in the breast milk consumed by him/her with the breast milk intake recorded by the United States Environmental Protection Agency for infants of his/her age divided by the infant's body weight. All the breast-milk samples were contaminated by AFM1 at levels ranging from 0.01 to 0.55ng/ml. Above 90% of samples exceeded the EU limit of 0.025ng/ml for infants’ foods while over 76% exceeded the EU limit of 0.05ng/ml for dairy milk and milk products. Only 1% of the samples exceeded the limit of 0.5ng/ml set for dairy milk in the United States and several countries in Asia. AFM1 Exposures ranged from 1.13 – 66.79ng/kg body weight per day. Small but significant (P<0.05) inverse association was observed between aflatoxin M1 exposure levels and weight for age Z-score or height for age Z-score. Appropriate strategies should be applied to minimize aflatoxin B1 exposure in lactating mothers so as to protect infants from aflatoxin M1 exposure
Keywords
DEVELOPING-COUNTRIES, HEALTH CONSEQUENCES, RURAL TANZANIA, WEST-AFRICA, CHILDREN, DETERMINANTS, CONTAMINATION, MOTHERS, mother, exclusive breastfeeding, aflatoxin, exposure assessment, FUMONISINS, PRODUCTS

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Citation

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Chicago
Magoha, Happy Steven, Martin Kimanya, Bruno De Meulenaer, Dominique Roberfroid, Carl Lachat, and Patrick Kolsteren. 2014. “Association Between Aflatoxin M₁ Exposure Through Breast Milk and Growth Impairment in Infants from Northern Tanzania.” World Mycotoxin Journal 7 (3): 277–284.
APA
Magoha, H. S., Kimanya, M., De Meulenaer, B., Roberfroid, D., Lachat, C., & Kolsteren, P. (2014). Association between aflatoxin M₁ exposure through breast milk and growth impairment in infants from Northern Tanzania. WORLD MYCOTOXIN JOURNAL, 7(3), 277–284.
Vancouver
1.
Magoha HS, Kimanya M, De Meulenaer B, Roberfroid D, Lachat C, Kolsteren P. Association between aflatoxin M₁ exposure through breast milk and growth impairment in infants from Northern Tanzania. WORLD MYCOTOXIN JOURNAL. 2014;7(3):277–84.
MLA
Magoha, Happy Steven, Martin Kimanya, Bruno De Meulenaer, et al. “Association Between Aflatoxin M₁ Exposure Through Breast Milk and Growth Impairment in Infants from Northern Tanzania.” WORLD MYCOTOXIN JOURNAL 7.3 (2014): 277–284. Print.
@article{5660885,
  abstract     = {Infants breastfeeding from mothers consuming aflatoxin contaminated foods may be exposed to aflatoxin M1(AFM1), a metabolite of aflatoxin B1. This study estimated the association between AFM1 exposure levels and growth indicators, for infants under six months of age in Northern Tanzania. A total of 143 infants and their mothers were involved. Breast-milk samples, infants{\textquoteright} anthropometric data and 24hr dietary recall for mothers were taken at the 1st, 3rd and 5th months of children age. AFM1 contaminations in the samples were determined using HPLC. AFM1 exposure by an infant was estimated by multiplying contamination in the breast milk consumed by him/her with the breast milk intake recorded by the United States Environmental Protection Agency for infants of his/her age divided by the infant's body weight. All the breast-milk samples were contaminated by AFM1 at levels ranging from 0.01 to 0.55ng/ml. Above 90\% of samples exceeded the EU limit of 0.025ng/ml for infants{\textquoteright} foods while over 76\% exceeded the EU limit of 0.05ng/ml for dairy milk and milk products. Only 1\% of the samples exceeded the limit of 0.5ng/ml set for dairy milk in the United States and several countries in Asia. AFM1 Exposures ranged from 1.13 -- 66.79ng/kg body weight per day. Small but significant (P{\textlangle}0.05) inverse association was observed between aflatoxin M1 exposure levels and weight for age Z-score or height for age Z-score. Appropriate strategies should be applied to minimize aflatoxin B1 exposure in lactating mothers so as to protect infants from aflatoxin M1 exposure},
  author       = {Magoha, Happy Steven and Kimanya, Martin and De Meulenaer, Bruno and Roberfroid, Dominique and Lachat, Carl and Kolsteren, Patrick},
  issn         = {1875-0710},
  journal      = {WORLD MYCOTOXIN JOURNAL},
  language     = {eng},
  number       = {3},
  pages        = {277--284},
  title        = {Association between aflatoxin M\unmatched{2081} exposure through breast milk and growth impairment in infants from Northern Tanzania},
  url          = {http://dx.doi.org/10.3920/WMJ2014.1705},
  volume       = {7},
  year         = {2014},
}

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