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Health-related quality of life in patients with melanoma expressed as utilities and disability weights

(2014) BRITISH JOURNAL OF DERMATOLOGY. 171(6). p.1443-1450
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Abstract
Background: Few studies about health-related quality of life (HRQoL) in patients with melanoma have expressed their results in terms of utilities or disability weights (DWs). Utilities are required for calculating quality-adjusted life years and therefore for cost-effectiveness analyses. DWs are useful to assess the burden of diseases through disability-adjusted life years. Objectives: To provide utilities and DWs regarding patients with melanoma. Methods: The patients were classified into eight groups using four stages based on the 2009 American Joint Committee on Cancer stages, with each stage subdivided into treatment and remission phases. The EuroQoL Five Dimensions Five Levels (EQ-5D-5L) questionnaire was completed by the patients with melanoma to provide a mean utility for each group. In addition to this, the EuroQoL visual analogue scale (VAS) and a validated quality-of-life questionnaire dedicated to patients with melanoma [ Functional Assessment of Cancer Therapy Melanoma (FACT-M)] were completed by the same patients in order to compare their results with the obtained utilities. DWs were obtained by calculating, for each patient, the difference between his/her utility and the corresponding sex-and age-specific population norm. Results: A total of 395 questionnaire sets were completed. Utilities and DWs showed significant differences between follow-up groups. Treatment groups had similar utilities and DWs but these results were obtained during different treatment durations and therefore have different weights. The VAS and the FACT-M were found to be less sensitive. Nevertheless, the FACT-M identified some problems not found by the EQ-5D-5L questionnaire. Conclusions: The EQ-5D-5L questionnaire seems adequate to provide utilities and DWs in patients with melanoma. Lower HRQoL in female patients with melanoma is probably linked to lower HRQoL in the general population.
Keywords
CUTANEOUS MELANOMA, LOCALIZED MALIGNANT-MELANOMA, COST-EFFECTIVENESS, SKIN-CANCER, EUROPEAN COUNTRIES, DUTCH-POPULATION, THE-LITERATURE, NODE BIOPSY, EQ-5D, DISEASE

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MLA
Tromme, Isabelle, Brecht Devleesschauwer, Philippe Beutels, et al. “Health-related Quality of Life in Patients with Melanoma Expressed as Utilities and Disability Weights.” BRITISH JOURNAL OF DERMATOLOGY 171.6 (2014): 1443–1450. Print.
APA
Tromme, I., Devleesschauwer, B., Beutels, P., Richez, P., Leroy, A., Baurain, J.-F., Cornelis, F., et al. (2014). Health-related quality of life in patients with melanoma expressed as utilities and disability weights. BRITISH JOURNAL OF DERMATOLOGY, 171(6), 1443–1450.
Chicago author-date
Tromme, Isabelle, Brecht Devleesschauwer, Philippe Beutels, Pauline Richez, Alice Leroy, Jean-François Baurain, Frank Cornelis, et al. 2014. “Health-related Quality of Life in Patients with Melanoma Expressed as Utilities and Disability Weights.” British Journal of Dermatology 171 (6): 1443–1450.
Chicago author-date (all authors)
Tromme, Isabelle, Brecht Devleesschauwer, Philippe Beutels, Pauline Richez, Alice Leroy, Jean-François Baurain, Frank Cornelis, Claude Bertrand, Nathalie Legrand, Jerome Degueldere, Luc Thomas, Catherine Legrand, Julien Lambert, Juanita Haagsma, and Niko Speybroeck. 2014. “Health-related Quality of Life in Patients with Melanoma Expressed as Utilities and Disability Weights.” British Journal of Dermatology 171 (6): 1443–1450.
Vancouver
1.
Tromme I, Devleesschauwer B, Beutels P, Richez P, Leroy A, Baurain J-F, et al. Health-related quality of life in patients with melanoma expressed as utilities and disability weights. BRITISH JOURNAL OF DERMATOLOGY. 2014;171(6):1443–50.
IEEE
[1]
I. Tromme et al., “Health-related quality of life in patients with melanoma expressed as utilities and disability weights,” BRITISH JOURNAL OF DERMATOLOGY, vol. 171, no. 6, pp. 1443–1450, 2014.
@article{5652078,
  abstract     = {Background: Few studies about health-related quality of life (HRQoL) in patients with melanoma have expressed their results in terms of utilities or disability weights (DWs). Utilities are required for calculating quality-adjusted life years and therefore for cost-effectiveness analyses. DWs are useful to assess the burden of diseases through disability-adjusted life years. 
Objectives: To provide utilities and DWs regarding patients with melanoma. 
Methods: The patients were classified into eight groups using four stages based on the 2009 American Joint Committee on Cancer stages, with each stage subdivided into treatment and remission phases. The EuroQoL Five Dimensions Five Levels (EQ-5D-5L) questionnaire was completed by the patients with melanoma to provide a mean utility for each group. In addition to this, the EuroQoL visual analogue scale (VAS) and a validated quality-of-life questionnaire dedicated to patients with melanoma [ Functional Assessment of Cancer Therapy Melanoma (FACT-M)] were completed by the same patients in order to compare their results with the obtained utilities. DWs were obtained by calculating, for each patient, the difference between his/her utility and the corresponding sex-and age-specific population norm. 
Results: A total of 395 questionnaire sets were completed. Utilities and DWs showed significant differences between follow-up groups. Treatment groups had similar utilities and DWs but these results were obtained during different treatment durations and therefore have different weights. The VAS and the FACT-M were found to be less sensitive. Nevertheless, the FACT-M identified some problems not found by the EQ-5D-5L questionnaire. 
Conclusions: The EQ-5D-5L questionnaire seems adequate to provide utilities and DWs in patients with melanoma. Lower HRQoL in female patients with melanoma is probably linked to lower HRQoL in the general population.},
  author       = {Tromme, Isabelle and Devleesschauwer, Brecht and Beutels, Philippe and Richez, Pauline and Leroy, Alice and Baurain, Jean-François and Cornelis, Frank and Bertrand, Claude and Legrand, Nathalie and Degueldere, Jerome and Thomas, Luc and Legrand, Catherine and Lambert, Julien and Haagsma, Juanita and Speybroeck, Niko},
  issn         = {0007-0963},
  journal      = {BRITISH JOURNAL OF DERMATOLOGY},
  keywords     = {CUTANEOUS MELANOMA,LOCALIZED MALIGNANT-MELANOMA,COST-EFFECTIVENESS,SKIN-CANCER,EUROPEAN COUNTRIES,DUTCH-POPULATION,THE-LITERATURE,NODE BIOPSY,EQ-5D,DISEASE},
  language     = {eng},
  number       = {6},
  pages        = {1443--1450},
  title        = {Health-related quality of life in patients with melanoma expressed as utilities and disability weights},
  url          = {http://dx.doi.org/10.1111/bjd.13262},
  volume       = {171},
  year         = {2014},
}

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