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Meta-analysis of dysphagia and aspiration pneumonia in frail elders

(2011) JOURNAL OF DENTAL RESEARCH. 90(12). p.1398-1404
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Abstract
As part of a systematic literature review, a comprehensive literature search was carried out to identify risk factors for aspiration pneumonia in frail older people. A prominent risk factor found was dysphagia with evidence level 2a, according to the Oxford Centre for Evidence-based Medicine Levels of Evidence. Subsequently, a meta-analysis of 4 cohort, 1 case-cohort, and 1 case-control study on dysphagia as a risk factor of aspiration pneumonia in frail older people was performed. Using a random effects model, we found a positive correlation between dysphagia and aspiration pneumonia: OR = 9.84; 95% CI = 4.15 - 23.33 (test for statistical homogeneity: p < 0.001). Then, a subgroup meta-analysis was performed with 4 cohort studies, all including patients with a cerebrovascular disease. Once again, a positive correlation was found between dysphagia and aspiration pneumonia: OR = 12.93; 95% CI = 8.61 - 19.44. The test for statistical homogeneity revealed no statistically significant result (p = 0.15). It was concluded that dysphagia is a serious risk factor for aspiration pneumonia in frail older people, particularly in those suffering from a cerebrovascular disease.
Keywords
RISK-FACTORS, OROPHARYNGEAL DYSPHAGIA, ACUTE STROKE, NURSING-HOME PATIENTS, DAILY ORAL CARE, swallowing, COMMUNITY-ACQUIRED PNEUMONIA, risk factor(s), oral-systemic disease(s), gerontology, dysphagia, oral hygiene, INFECTION, BACTERIA, COHORT, PREDICTORS

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Chicago
van der Maarel-Wierink, Claar D, Jacques Vanobbergen, Ewald M Bronkhorst, Jos MGA Schols, and Cees de Baat. 2011. “Meta-analysis of Dysphagia and Aspiration Pneumonia in Frail Elders.” Journal of Dental Research 90 (12): 1398–1404.
APA
van der Maarel-Wierink, C. D., Vanobbergen, J., Bronkhorst, E. M., Schols, J. M., & de Baat, C. (2011). Meta-analysis of dysphagia and aspiration pneumonia in frail elders. JOURNAL OF DENTAL RESEARCH, 90(12), 1398–1404.
Vancouver
1.
van der Maarel-Wierink CD, Vanobbergen J, Bronkhorst EM, Schols JM, de Baat C. Meta-analysis of dysphagia and aspiration pneumonia in frail elders. JOURNAL OF DENTAL RESEARCH. 2011;90(12):1398–404.
MLA
van der Maarel-Wierink, Claar D, Jacques Vanobbergen, Ewald M Bronkhorst, et al. “Meta-analysis of Dysphagia and Aspiration Pneumonia in Frail Elders.” JOURNAL OF DENTAL RESEARCH 90.12 (2011): 1398–1404. Print.
@article{5646325,
  abstract     = {As part of a systematic literature review, a comprehensive literature search was carried out to identify risk factors for aspiration pneumonia in frail older people. A prominent risk factor found was dysphagia with evidence level 2a, according to the Oxford Centre for Evidence-based Medicine Levels of Evidence. Subsequently, a meta-analysis of 4 cohort, 1 case-cohort, and 1 case-control study on dysphagia as a risk factor of aspiration pneumonia in frail older people was performed. Using a random effects model, we found a positive correlation between dysphagia and aspiration pneumonia: OR = 9.84; 95\% CI = 4.15 - 23.33 (test for statistical homogeneity: p {\textlangle} 0.001). Then, a subgroup meta-analysis was performed with 4 cohort studies, all including patients with a cerebrovascular disease. Once again, a positive correlation was found between dysphagia and aspiration pneumonia: OR = 12.93; 95\% CI = 8.61 - 19.44. The test for statistical homogeneity revealed no statistically significant result (p = 0.15). It was concluded that dysphagia is a serious risk factor for aspiration pneumonia in frail older people, particularly in those suffering from a cerebrovascular disease.},
  author       = {van der Maarel-Wierink, Claar D and Vanobbergen, Jacques and Bronkhorst, Ewald M and Schols, Jos MGA and de Baat, Cees},
  issn         = {0022-0345},
  journal      = {JOURNAL OF DENTAL RESEARCH},
  keyword      = {RISK-FACTORS,OROPHARYNGEAL DYSPHAGIA,ACUTE STROKE,NURSING-HOME PATIENTS,DAILY ORAL CARE,swallowing,COMMUNITY-ACQUIRED PNEUMONIA,risk factor(s),oral-systemic disease(s),gerontology,dysphagia,oral hygiene,INFECTION,BACTERIA,COHORT,PREDICTORS},
  language     = {eng},
  number       = {12},
  pages        = {1398--1404},
  title        = {Meta-analysis of dysphagia and aspiration pneumonia in frail elders},
  url          = {http://dx.doi.org/10.1177/0022034511422909},
  volume       = {90},
  year         = {2011},
}

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