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Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis

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Abstract
Introduction: We sought to assess whether nailfold videocapillaroscopy (NVC) patterns are associated with levels of angiogenic factors in systemic sclerosis (SSc). Methods: Circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) were measured in the peripheral blood of 60 consecutive SSc patients. Serum levels of eight endothelial markers were measured first in these 60 patients, and then in an independent replication cohort of 43 SSc patients in case of association with NVC patterns. NVC patterns were determined by four independent investigators blinded to vascular markers. Results: Patients with the late-NVC pattern exhibited lower EPC levels (P < 0.0001) and higher VEGF levels (P = 0.03). Higher VEGF levels were confirmed to be associated with the late-NVC pattern in the replication cohort (P = 0.01). By multivariate analysis focused on biomarkers, lower EPC (P = 0.03) and higher VEGF levels (P = 0.001) were independently associated with the late-NVC pattern. In an alternate multivariate model including these two factors and SSc-related disease characteristics, lower EPC counts (P = 0.005), higher VEGF levels (P = 0.01), a history of digital ulcers (P = 0.04), and a modified Rodnan skin score > 14 (P < 0.0001) were independently associated with the late-NVC pattern. Conclusion: Our data revealed decreased EPC counts and increased VEGF levels in patients with the late-NVC pattern. Further studies are now needed to determine the role of VEGF and EPCs in endothelial injury and repair in SSc.
Keywords
MANIFESTATIONS, ASSOCIATION, VASCULAR-DISEASE, SCLERODERMA PATIENTS, RHEUMATOID-ARTHRITIS, PROGENITOR CELLS, ULCER RISK INDEX, PULMONARY ARTERIAL-HYPERTENSION, ENDOTHELIAL GROWTH-FACTOR, INVOLVEMENT

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Chicago
Avouac, Jérôme, Maeva Vallucci, Vanessa Smith, Patricia Senet, Barbara Ruiz, Alberto Sulli, Carmen Pizzorni, et al. 2013. “Correlations Between Angiogenic Factors and Capillaroscopic Patterns in Systemic Sclerosis.” Arthritis Research & Therapy 15 (2).
APA
Avouac, Jérôme, Vallucci, M., Smith, V., Senet, P., Ruiz, B., Sulli, A., Pizzorni, C., et al. (2013). Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis. ARTHRITIS RESEARCH & THERAPY, 15(2).
Vancouver
1.
Avouac J, Vallucci M, Smith V, Senet P, Ruiz B, Sulli A, et al. Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis. ARTHRITIS RESEARCH & THERAPY. 2013;15(2).
MLA
Avouac, Jérôme, Maeva Vallucci, Vanessa Smith, et al. “Correlations Between Angiogenic Factors and Capillaroscopic Patterns in Systemic Sclerosis.” ARTHRITIS RESEARCH & THERAPY 15.2 (2013): n. pag. Print.
@article{5638331,
  abstract     = {Introduction: We sought to assess whether nailfold videocapillaroscopy (NVC) patterns are associated with levels of angiogenic factors in systemic sclerosis (SSc).
Methods: Circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) were measured in the peripheral blood of 60 consecutive SSc patients. Serum levels of eight endothelial markers were measured first in these 60 patients, and then in an independent replication cohort of 43 SSc patients in case of association with NVC patterns. NVC patterns were determined by four independent investigators blinded to vascular markers.
Results: Patients with the late-NVC pattern exhibited lower EPC levels (P {\textlangle} 0.0001) and higher VEGF levels (P = 0.03). Higher VEGF levels were confirmed to be associated with the late-NVC pattern in the replication cohort (P = 0.01). By multivariate analysis focused on biomarkers, lower EPC (P = 0.03) and higher VEGF levels (P = 0.001) were independently associated with the late-NVC pattern. In an alternate multivariate model including these two factors and SSc-related disease characteristics, lower EPC counts (P = 0.005), higher VEGF levels (P = 0.01), a history of digital ulcers (P = 0.04), and a modified Rodnan skin score {\textrangle} 14 (P {\textlangle} 0.0001) were independently associated with the late-NVC pattern.
Conclusion: Our data revealed decreased EPC counts and increased VEGF levels in patients with the late-NVC pattern. Further studies are now needed to determine the role of VEGF and EPCs in endothelial injury and repair in SSc.},
  articleno    = {R55},
  author       = {Avouac, J{\'e}r{\^o}me and Vallucci, Maeva and Smith, Vanessa and Senet, Patricia and Ruiz, Barbara and Sulli, Alberto and Pizzorni, Carmen and Frances, Camille and Chiocchia, Gilles and Cutolo, Maurizio and Allanore, Yannick},
  issn         = {1478-6354},
  journal      = {ARTHRITIS RESEARCH \& THERAPY},
  keyword      = {MANIFESTATIONS,ASSOCIATION,VASCULAR-DISEASE,SCLERODERMA PATIENTS,RHEUMATOID-ARTHRITIS,PROGENITOR CELLS,ULCER RISK INDEX,PULMONARY ARTERIAL-HYPERTENSION,ENDOTHELIAL GROWTH-FACTOR,INVOLVEMENT},
  language     = {eng},
  number       = {2},
  pages        = {10},
  title        = {Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis},
  url          = {http://dx.doi.org/10.1186/ar4217},
  volume       = {15},
  year         = {2013},
}

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