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Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis

Vanessa Smith UGent, Valeria Riccieri, Carmen Pizzorni, Saskia Decuman UGent, Ellen Deschepper UGent, CAROLIEN BONROY, Alberto Sulli, YVES PIETTE UGent, Filip De Keyser UGent and Maurizio Cutolo (2013) JOURNAL OF RHEUMATOLOGY. 40(12). p.2023-2028
abstract
Objective. Assessment of associations of nailfold videocapillaroscopy (NVC) scleroderma (systemic sclerosis; SSc) ("early," "active," and "late") with novel future severe clinical involvement in 2 independent cohorts. Methods. Sixty-six consecutive Belgian and 82 Italian patients with SSc underwent NYC at baseline. Images were blindly assessed and classified into normal, early, active, or late NYC pattern. Clinical evaluation was performed for 9 organ systems (general, peripheral vascular, skin, joint, muscle, gastrointestinal tract, lung, heart, and kidney) according to the Medsger disease severity scale (DSS) at baseline and in the future (18-24 months of followup). Severe clinical involvement was defined as category 2 to 4 per organ of the DSS. Logistic regression analysis (continuous NYC predictor variable) was performed. Results. The OR to develop novel future severe organ involvement was stronger according to more severe NVC patterns and similar in both cohorts. In simple logistic regression analysis the OR in the Belgian/Italian cohort was 2.16 (95% CI 1.19-4.47, p = 0.010)/2.33 (95% CI 1.36-4.22, p = 0.002) for the early NYC SSc pattern, 4.68/5.42 for the active pattern, and 10.14/12.63 for the late pattern versus the normal pattern. In multiple logistic regression analysis, adjusting for disease duration, subset, and vasoactive medication, the OR was 2.99 (95% CI 1.31-8.82, p = 0.007)/1.88 (95% CI 1.00-3.71, p = 0.050) for the early NYC SSc pattern, 8.93/3.54 for the active pattern, and 26.69/6.66 for the late pattern versus the normal pattern. Conclusion. Capillaroscopy may be predictive of novel future severe organ involvement in SSc, as attested by 2 independent cohorts.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PREDICTION, NAILFOLD VIDEOCAPILLAROSCOPY, ORGAN INVOLVEMENT, DISEASE SEVERITY MEDSGER SCALE, SYSTEMIC SCLEROSIS, VIDEOCAPILLAROSCOPY ASSESSMENT, MICROVASCULAR DAMAGE, PATTERNS
journal title
JOURNAL OF RHEUMATOLOGY
J. Rheumatol.
volume
40
issue
12
pages
2023 - 2028
Web of Science type
Article
Web of Science id
000328299100015
JCR category
RHEUMATOLOGY
JCR impact factor
3.173 (2013)
JCR rank
11/30 (2013)
JCR quartile
2 (2013)
ISSN
0315-162X
DOI
10.3899/jrheum.130528
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5638319
handle
http://hdl.handle.net/1854/LU-5638319
date created
2014-07-07 09:22:42
date last changed
2016-12-19 15:39:14
@article{5638319,
  abstract     = {Objective. Assessment of associations of nailfold videocapillaroscopy (NVC) scleroderma (systemic sclerosis; SSc) ({\textacutedbl}early,{\textacutedbl} {\textacutedbl}active,{\textacutedbl} and {\textacutedbl}late{\textacutedbl}) with novel future severe clinical involvement in 2 independent cohorts.
Methods. Sixty-six consecutive Belgian and 82 Italian patients with SSc underwent NYC at baseline. Images were blindly assessed and classified into normal, early, active, or late NYC pattern. Clinical evaluation was performed for 9 organ systems (general, peripheral vascular, skin, joint, muscle, gastrointestinal tract, lung, heart, and kidney) according to the Medsger disease severity scale (DSS) at baseline and in the future (18-24 months of followup). Severe clinical involvement was defined as category 2 to 4 per organ of the DSS. Logistic regression analysis (continuous NYC predictor variable) was performed.
Results. The OR to develop novel future severe organ involvement was stronger according to more severe NVC patterns and similar in both cohorts. In simple logistic regression analysis the OR in the Belgian/Italian cohort was 2.16 (95\% CI 1.19-4.47, p = 0.010)/2.33 (95\% CI 1.36-4.22, p = 0.002) for the early NYC SSc pattern, 4.68/5.42 for the active pattern, and 10.14/12.63 for the late pattern versus the normal pattern. In multiple logistic regression analysis, adjusting for disease duration, subset, and vasoactive medication, the OR was 2.99 (95\% CI 1.31-8.82, p = 0.007)/1.88 (95\% CI 1.00-3.71, p = 0.050) for the early NYC SSc pattern, 8.93/3.54 for the active pattern, and 26.69/6.66 for the late pattern versus the normal pattern.
Conclusion. Capillaroscopy may be predictive of novel future severe organ involvement in SSc, as attested by 2 independent cohorts.},
  author       = {Smith, Vanessa and Riccieri, Valeria and Pizzorni, Carmen and Decuman, Saskia and Deschepper, Ellen and BONROY, CAROLIEN and Sulli, Alberto and PIETTE, YVES and De Keyser, Filip and Cutolo, Maurizio},
  issn         = {0315-162X},
  journal      = {JOURNAL OF RHEUMATOLOGY},
  keyword      = {PREDICTION,NAILFOLD VIDEOCAPILLAROSCOPY,ORGAN INVOLVEMENT,DISEASE SEVERITY MEDSGER SCALE,SYSTEMIC SCLEROSIS,VIDEOCAPILLAROSCOPY ASSESSMENT,MICROVASCULAR DAMAGE,PATTERNS},
  language     = {eng},
  number       = {12},
  pages        = {2023--2028},
  title        = {Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis},
  url          = {http://dx.doi.org/10.3899/jrheum.130528},
  volume       = {40},
  year         = {2013},
}

Chicago
Smith, Vanessa, Valeria Riccieri, Carmen Pizzorni, Saskia Decuman, Ellen Deschepper, CAROLIEN BONROY, Alberto Sulli, YVES PIETTE, Filip De Keyser, and Maurizio Cutolo. 2013. “Nailfold Capillaroscopy for Prediction of Novel Future Severe Organ Involvement in Systemic Sclerosis.” Journal of Rheumatology 40 (12): 2023–2028.
APA
Smith, V., Riccieri, V., Pizzorni, C., Decuman, S., Deschepper, E., BONROY, C., Sulli, A., et al. (2013). Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis. JOURNAL OF RHEUMATOLOGY, 40(12), 2023–2028.
Vancouver
1.
Smith V, Riccieri V, Pizzorni C, Decuman S, Deschepper E, BONROY C, et al. Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis. JOURNAL OF RHEUMATOLOGY. 2013;40(12):2023–8.
MLA
Smith, Vanessa, Valeria Riccieri, Carmen Pizzorni, et al. “Nailfold Capillaroscopy for Prediction of Novel Future Severe Organ Involvement in Systemic Sclerosis.” JOURNAL OF RHEUMATOLOGY 40.12 (2013): 2023–2028. Print.