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Nailfold capillary abnormalities in erectile dysfunction of systemic sclerosis: a EUSTAR group analysis

(2014) RHEUMATOLOGY. 53(4). p.639-643
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Organization
Abstract
Methods. A cross-sectional analysis of the prospective European League Against Rheumatism (EULAR) Scleroderma Trial and Research database was performed. Men with SSc were included if they had undergone nailfold capillaroscopy and simultaneous ED assessment with the 5-item International Index for Erectile Function (IIEF-5). Results. Eighty-six men met the inclusion criteria. Eight men (9.3%) had not had sexual intercourse and could not be assigned an IIEF-5 score. Sixty-nine of the 78 men (88.5%) with an IIEF-5 score had nailfold capillary abnormalities, of whom 54 (78.3%) suffered from ED. Nine men (11.5%) had no nailfold capillary abnormalities, of whom six (66.7%) had ED (P = 0.44). ED was more frequent in older men (P = 0.002) and in men with diffuse disease (P = 0.06). Men with abnormal capillaroscopy had a higher median EULAR disease activity than men without (P = 0.02), a lower diffusing capacity of the lung (P = 0.001) and a higher modified Rodnan skin score (P = 0.04), but mean IIEF-5 scores did not differ [15.7 (s.d. 6.2) vs 15.7 (s.d. 6.3)]. IIEF-5 scores did not differ between men with early (n = 12), active (n = 27) or late (n = 27) patterns (IIEF-5 scores of 17.9, 16.3 and 14.7, respectively). There were no differences in the prevalence of early, active and late capillaroscopy patterns between men with or without ED. Conclusion. Neither the presence or absence of abnormal capillaroscopy findings nor the subdivision into early, active and late patterns is associated with coexistent ED in SSc.
Keywords
DISEASE, TOOL, SEVERITY, PATTERNS, SCLERODERMA, VIDEOCAPILLAROSCOPY ASSESSMENT, ULCER RISK INDEX, pathogenesis, vasculopathy, ageing, erectile dysfunction, scleroderma pattern, nailfold capillaroscopy, systemic sclerosis

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Citation

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Chicago
Keck, Andrea D, Chingching Foocharoen, Edoardo Rosato, Vanessa Smith, Yannick Allanore, Oliver Distler, Bojana Stamenkovic, et al. 2014. “Nailfold Capillary Abnormalities in Erectile Dysfunction of Systemic Sclerosis: a EUSTAR Group Analysis.” Rheumatology 53 (4): 639–643.
APA
Keck, A. D., Foocharoen, C., Rosato, E., Smith, V., Allanore, Y., Distler, O., Stamenkovic, B., et al. (2014). Nailfold capillary abnormalities in erectile dysfunction of systemic sclerosis: a EUSTAR group analysis. RHEUMATOLOGY, 53(4), 639–643.
Vancouver
1.
Keck AD, Foocharoen C, Rosato E, Smith V, Allanore Y, Distler O, et al. Nailfold capillary abnormalities in erectile dysfunction of systemic sclerosis: a EUSTAR group analysis. RHEUMATOLOGY. 2014;53(4):639–43.
MLA
Keck, Andrea D, Chingching Foocharoen, Edoardo Rosato, et al. “Nailfold Capillary Abnormalities in Erectile Dysfunction of Systemic Sclerosis: a EUSTAR Group Analysis.” RHEUMATOLOGY 53.4 (2014): 639–643. Print.
@article{5638252,
  abstract     = {Methods. A cross-sectional analysis of the prospective European League Against Rheumatism (EULAR) Scleroderma Trial and Research database was performed. Men with SSc were included if they had undergone nailfold capillaroscopy and simultaneous ED assessment with the 5-item International Index for Erectile Function (IIEF-5).
Results. Eighty-six men met the inclusion criteria. Eight men (9.3%) had not had sexual intercourse and could not be assigned an IIEF-5 score. Sixty-nine of the 78 men (88.5%) with an IIEF-5 score had nailfold capillary abnormalities, of whom 54 (78.3%) suffered from ED. Nine men (11.5%) had no nailfold capillary abnormalities, of whom six (66.7%) had ED (P = 0.44). ED was more frequent in older men (P = 0.002) and in men with diffuse disease (P = 0.06). Men with abnormal capillaroscopy had a higher median EULAR disease activity than men without (P = 0.02), a lower diffusing capacity of the lung (P = 0.001) and a higher modified Rodnan skin score (P = 0.04), but mean IIEF-5 scores did not differ [15.7 (s.d. 6.2) vs 15.7 (s.d. 6.3)]. IIEF-5 scores did not differ between men with early (n = 12), active (n = 27) or late (n = 27) patterns (IIEF-5 scores of 17.9, 16.3 and 14.7, respectively). There were no differences in the prevalence of early, active and late capillaroscopy patterns between men with or without ED. 
Conclusion. Neither the presence or absence of abnormal capillaroscopy findings nor the subdivision into early, active and late patterns is associated with coexistent ED in SSc.},
  author       = {Keck, Andrea D and Foocharoen, Chingching and Rosato, Edoardo and Smith, Vanessa and Allanore, Yannick and Distler, Oliver and Stamenkovic, Bojana and Pereira Da Silva, José Antonio and Khelifa, Sondess Hadj and Denisov, Lev N and Hachulla, Eric and de la Peña Lefebvre, Paloma García and Sibilia, Jean and Airò, Paolo and Caramaschi, Paola and Müller-Ladner, Ulf and Wiland, Piotr and Walker, Ulrich A},
  issn         = {1462-0324},
  journal      = {RHEUMATOLOGY},
  keywords     = {DISEASE,TOOL,SEVERITY,PATTERNS,SCLERODERMA,VIDEOCAPILLAROSCOPY ASSESSMENT,ULCER RISK INDEX,pathogenesis,vasculopathy,ageing,erectile dysfunction,scleroderma pattern,nailfold capillaroscopy,systemic sclerosis},
  language     = {eng},
  number       = {4},
  pages        = {639--643},
  title        = {Nailfold capillary abnormalities in erectile dysfunction of systemic sclerosis: a EUSTAR group analysis},
  url          = {http://dx.doi.org/10.1093/rheumatology/ket392},
  volume       = {53},
  year         = {2014},
}

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