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Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis

S Zhou, Y Wang, Thomas De Beer UGent, Willy Baeyens UGent, GT Fei, M Dilinuer and J Ouyang (2008) ELECTROPHORESIS. 29(11). p.2321-2329
abstract
The analysis is described for separating seven beta-adrenergic blocking agents (atenolol, celiprolol, clorprenaline, fenoterol, metoprolol, propranolol, terbutaline) and clenbuterol (sympathomimetic beta-2 receptor stimulating agonist, decongestant and bronchodilator, illicit anabolic used in athletics) by CE with UV detection. In order to simultaneously separate all analytes, Tris-H3PO4 solution was applied containing titanium dioxide nanoparticles (TiO2 NPs) as BGEs. The effects of important factors, such as concentration of TiO2. NPs, optimum pH, run buffer concentration, and separation voltage, were investigated so as to achieve best CE separation. The eight analytes could be well separated applying a separation voltage of 15 kV in 75 mM Tris-H3PO4 buffer at a pH of 2.40, containing 6.0 x 10(-6) g/mL TiO2 NPs. Under these optimal conditions, the RSDs for peak areas and for migration times were less than 2.7 and 2.3%, respectively. The detection limits were 0.1 mu g/mL for celiprolol, 0.1 mu g/mL for propranolol, 0.2 mu g/mL for fenoterol, 1.0 mu g/mL for atenolol, 1.0 mu g/mL, for clenbuterol, 1.0 mu g/mL for clorprenaline, 1.0 mu g/mL for metoprolol, and 1.0 mu g/mL for terbutaline. The proposed method was successfully applied for the rapid CE determination of the frequently applied antihypertensive P-blocking compounds atenolol, metoprolol, terbutaline, and propranolol in pharmaceutical tablets.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SOLUTION INTERFACE, BLOCKERS, STATIONARY-PHASE, ZONE-ELECTROPHORESIS, LIQUID-CHROMATOGRAPHY, beta-adrenergic antagonists, beta-adrenergic agonist, capillary electrophoresis, titanium dioxide nanoparticles, IONIZATION-MASS-SPECTROMETRY, PART I, CARBON NANOTUBES, ELECTROKINETIC CHROMATOGRAPHY, ELECTROCHROMATOGRAPHIC SEPARATION
journal title
ELECTROPHORESIS
volume
29
issue
11
pages
2321 - 2329
publisher
WILEY-V C H VERLAG GMBH
place of publication
PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
Web of Science type
Article
Web of Science id
000257011600011
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
3.509 (2008)
JCR rank
7/70 (2008)
JCR quartile
1 (2008)
ISSN
0173-0835
DOI
10.1002/elps.200700589
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
539317
handle
http://hdl.handle.net/1854/LU-539317
date created
2009-04-07 15:31:33
date last changed
2009-04-09 11:01:37
@article{539317,
  abstract     = {The analysis is described for separating seven beta-adrenergic blocking agents (atenolol, celiprolol, clorprenaline, fenoterol, metoprolol, propranolol, terbutaline) and clenbuterol (sympathomimetic beta-2 receptor stimulating agonist, decongestant and bronchodilator, illicit anabolic used in athletics) by CE with UV detection. In order to simultaneously separate all analytes, Tris-H3PO4 solution was applied containing titanium dioxide nanoparticles (TiO2 NPs) as BGEs. The effects of important factors, such as concentration of TiO2. NPs, optimum pH, run buffer concentration, and separation voltage, were investigated so as to achieve best CE separation. The eight analytes could be well separated applying a separation voltage of 15 kV in 75 mM Tris-H3PO4 buffer at a pH of 2.40, containing 6.0 x 10(-6) g/mL TiO2 NPs. Under these optimal conditions, the RSDs for peak areas and for migration times were less than 2.7 and 2.3\%, respectively. The detection limits were 0.1 mu g/mL for celiprolol, 0.1 mu g/mL for propranolol, 0.2 mu g/mL for fenoterol, 1.0 mu g/mL for atenolol, 1.0 mu g/mL, for clenbuterol, 1.0 mu g/mL for clorprenaline, 1.0 mu g/mL for metoprolol, and 1.0 mu g/mL for terbutaline. The proposed method was successfully applied for the rapid CE determination of the frequently applied antihypertensive P-blocking compounds atenolol, metoprolol, terbutaline, and propranolol in pharmaceutical tablets.},
  author       = {Zhou, S and Wang, Y and De Beer, Thomas and Baeyens, Willy and Fei, GT and Dilinuer, M and Ouyang, J},
  issn         = {0173-0835},
  journal      = {ELECTROPHORESIS},
  keyword      = {SOLUTION INTERFACE,BLOCKERS,STATIONARY-PHASE,ZONE-ELECTROPHORESIS,LIQUID-CHROMATOGRAPHY,beta-adrenergic antagonists,beta-adrenergic agonist,capillary electrophoresis,titanium dioxide nanoparticles,IONIZATION-MASS-SPECTROMETRY,PART I,CARBON NANOTUBES,ELECTROKINETIC CHROMATOGRAPHY,ELECTROCHROMATOGRAPHIC SEPARATION},
  language     = {eng},
  number       = {11},
  pages        = {2321--2329},
  publisher    = {WILEY-V C H VERLAG GMBH},
  title        = {Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis},
  url          = {http://dx.doi.org/10.1002/elps.200700589},
  volume       = {29},
  year         = {2008},
}

Chicago
Zhou, S, Y Wang, Thomas De Beer, Willy Baeyens, GT Fei, M Dilinuer, and J Ouyang. 2008. “Simultaneous Separation of Eight Beta-adrenergic Drugs Using Titanium Dioxide Nanoparticles as Additive in Capillary Electrophoresis.” Electrophoresis 29 (11): 2321–2329.
APA
Zhou, S., Wang, Y., De Beer, T., Baeyens, W., Fei, G., Dilinuer, M., & Ouyang, J. (2008). Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis. ELECTROPHORESIS, 29(11), 2321–2329.
Vancouver
1.
Zhou S, Wang Y, De Beer T, Baeyens W, Fei G, Dilinuer M, et al. Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis. ELECTROPHORESIS. PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY: WILEY-V C H VERLAG GMBH; 2008;29(11):2321–9.
MLA
Zhou, S, Y Wang, Thomas De Beer, et al. “Simultaneous Separation of Eight Beta-adrenergic Drugs Using Titanium Dioxide Nanoparticles as Additive in Capillary Electrophoresis.” ELECTROPHORESIS 29.11 (2008): 2321–2329. Print.