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Regional brain perfusion in epileptic dogs evaluated by technetium-99m-ethyl cysteinate dimer SPECT

Valentine Martlé (UGent) , Kathelijne Peremans (UGent) , Kurt Audenaert (UGent) , Simon Vermeire (UGent) , Sofie Bhatti (UGent) , Ingrid Gielen (UGent) , Ingeborgh Polis (UGent) and Luc Van Ham (UGent)
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Abstract
We evaluated the feasibility of interictal single photon emission computed tomography (SPECT) to detect alterations in regional cerebral blood flow and neuronal activity in dogs with idiopathic epilepsy. Twelve dogs with idiopathic epilepsy underwent interictal technetium-99m-ethyl cysteinate dimer SPECT of the brain. Different cortical regions of interest (ROIs), 1 ROI at the cerebellum and 1 ROI at the subcortical area were evaluated by semiquantitative analysis and compared with a control group (18 dogs). Significant hypoperfusion (P=0.02) was present in the subcortical area of epileptic dogs. This hypoperfusion was not associated with seizure frequency, age at onset of seizures, duration of epilepsy, or time since the last seizure. Interictal SPECT did not reveal cortical or cerebellar perfusion alterations. The subcortical area may play an important role in the pathophysiology of canine idiopathic epilepsy.
Keywords
dog, PET, HYPOPERFUSION, LOCALIZING VALUE, INTERICTAL SPECT, ABSENCE SEIZURES, TEMPORAL-LOBE EPILEPSY, SEIZURE LOCALIZATION, epilepsy, interictal SPECT, thalamus

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MLA
Martlé, Valentine, Kathelijne Peremans, Kurt Audenaert, et al. “Regional Brain Perfusion in Epileptic Dogs Evaluated by Technetium-99m-ethyl Cysteinate Dimer SPECT.” VETERINARY RADIOLOGY & ULTRASOUND 50.6 (2009): 655–659. Print.
APA
Martlé, V., Peremans, K., Audenaert, K., Vermeire, S., Bhatti, S., Gielen, I., Polis, I., et al. (2009). Regional brain perfusion in epileptic dogs evaluated by technetium-99m-ethyl cysteinate dimer SPECT. VETERINARY RADIOLOGY & ULTRASOUND, 50(6), 655–659. Presented at the 21st Annual symposium of the European Society of Veterinary Neurology.
Chicago author-date
Martlé, Valentine, Kathelijne Peremans, Kurt Audenaert, Simon Vermeire, Sofie Bhatti, Ingrid Gielen, Ingeborgh Polis, and Luc Van Ham. 2009. “Regional Brain Perfusion in Epileptic Dogs Evaluated by Technetium-99m-ethyl Cysteinate Dimer SPECT.” Veterinary Radiology & Ultrasound 50 (6): 655–659.
Chicago author-date (all authors)
Martlé, Valentine, Kathelijne Peremans, Kurt Audenaert, Simon Vermeire, Sofie Bhatti, Ingrid Gielen, Ingeborgh Polis, and Luc Van Ham. 2009. “Regional Brain Perfusion in Epileptic Dogs Evaluated by Technetium-99m-ethyl Cysteinate Dimer SPECT.” Veterinary Radiology & Ultrasound 50 (6): 655–659.
Vancouver
1.
Martlé V, Peremans K, Audenaert K, Vermeire S, Bhatti S, Gielen I, et al. Regional brain perfusion in epileptic dogs evaluated by technetium-99m-ethyl cysteinate dimer SPECT. VETERINARY RADIOLOGY & ULTRASOUND. 2009;50(6):655–9.
IEEE
[1]
V. Martlé et al., “Regional brain perfusion in epileptic dogs evaluated by technetium-99m-ethyl cysteinate dimer SPECT,” VETERINARY RADIOLOGY & ULTRASOUND, vol. 50, no. 6, pp. 655–659, 2009.
@article{538775,
  abstract     = {We evaluated the feasibility of interictal single photon emission computed tomography (SPECT) to detect alterations in regional cerebral blood flow and neuronal activity in dogs with idiopathic epilepsy. Twelve dogs with idiopathic epilepsy underwent interictal technetium-99m-ethyl cysteinate dimer SPECT of the brain. Different cortical regions of interest (ROIs), 1 ROI at the cerebellum and 1 ROI at the subcortical area were evaluated by semiquantitative analysis and compared with a control group (18 dogs). Significant hypoperfusion (P=0.02) was present in the subcortical area of epileptic dogs. This hypoperfusion was not associated with seizure frequency, age at onset of seizures, duration of epilepsy, or time since the last seizure. Interictal SPECT did not reveal cortical or cerebellar perfusion alterations. The subcortical area may play an important role in the pathophysiology of canine idiopathic epilepsy.},
  author       = {Martlé, Valentine and Peremans, Kathelijne and Audenaert, Kurt and Vermeire, Simon and Bhatti, Sofie and Gielen, Ingrid and Polis, Ingeborgh and Van Ham, Luc},
  issn         = {1058-8183},
  journal      = {VETERINARY RADIOLOGY & ULTRASOUND},
  keywords     = {dog,PET,HYPOPERFUSION,LOCALIZING VALUE,INTERICTAL SPECT,ABSENCE SEIZURES,TEMPORAL-LOBE EPILEPSY,SEIZURE LOCALIZATION,epilepsy,interictal SPECT,thalamus},
  language     = {eng},
  location     = {Rhodes, Greece},
  number       = {6},
  pages        = {655--659},
  title        = {Regional brain perfusion in epileptic dogs evaluated by technetium-99m-ethyl cysteinate dimer SPECT},
  url          = {http://dx.doi.org/10.1111/j.1740-8261.2009.01600.x},
  volume       = {50},
  year         = {2009},
}

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