C-reactive protein levels, haplotypes and the risk of incident chronic obstructive pulmonary disease
- Author
- YANNICK VAN DURME (UGent) , Katia Verhamme, Albert-Jan Aarnoudse, Geert Van Pottelberge, Albert Hofman, Jacqueline Witteman, Guy Joos (UGent) , Guy Brusselle (UGent) and Bruno Stricker
- Organization
- Abstract
- Rationale Chronic obstructive pulmonary disease (COPD) is characterized by substantial chronic inflammation in the pulmonary compartment as well as in the systemic circulation. Objectives: To investigate potentially causal association, we examined whether serum levels of high-sensitivity C-reactive protein (hsCRP) and variations in the CRP gene are associated with the risk of developing COPD. Methods: This study is part of the Rotterdam Study, a prospective population-based cohort study among subjects aged 55 years or older. At baseline, 6,836 subjects without COPD had a blood sample available for assessment of hsCRP serum levels and haplotypes of the CRP gene. We analyzed the association between hsCRP levels, CRIP gene haplotypes, and incident COPD with Cox proportional hazard models, adjusted for age, sex, and other confounders. Measurements and Main Results: High levels of hsCRP (>3 mg/L) were associated with a significantly increased risk of incident COPD (hazard ratio [HR], 1.7; 95% confidence interval [CI], 1.16-2.49) compared with persons with low levels (< 1 mg/L). The risk remained increased after adjusting for potential confounders and introducing a latency period of 3 years. The risk was most pronounced in former smokers (HR, 2.2; 95% CI, 1.12-3.74). hsCRP was not a risk factor in never smokers. No CRP single nucleoticle polymorphism or haplotype was associated with a significantly increased or decreased COPD risk. Conclusions: Increased hsCRP levels are predictive for the occurrence of COPD in smokers. However, haplotypes of the CRP gene, which influence hsCRP levels, are not associated with an altered risk of developing COPD.
- Keywords
- C-reactive protein, Chronic obstructive pulmonary disease, genetics epidemiology
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-538272
- MLA
- VAN DURME, YANNICK, et al. “C-Reactive Protein Levels, Haplotypes and the Risk of Incident Chronic Obstructive Pulmonary Disease.” American Journal of Respiratory Critical Care Medicine, vol. 179, no. 5, Amer Thoracic Soc, 2009, pp. 375–82, doi:10.1164/rccm.200810-1540OC.
- APA
- VAN DURME, Y., Verhamme, K., Aarnoudse, A.-J., Van Pottelberge, G., Hofman, A., Witteman, J., … Stricker, B. (2009). C-reactive protein levels, haplotypes and the risk of incident chronic obstructive pulmonary disease. American Journal of Respiratory Critical Care Medicine, 179(5), 375–382. https://doi.org/10.1164/rccm.200810-1540OC
- Chicago author-date
- VAN DURME, YANNICK, Katia Verhamme, Albert-Jan Aarnoudse, Geert Van Pottelberge, Albert Hofman, Jacqueline Witteman, Guy Joos, Guy Brusselle, and Bruno Stricker. 2009. “C-Reactive Protein Levels, Haplotypes and the Risk of Incident Chronic Obstructive Pulmonary Disease.” American Journal of Respiratory Critical Care Medicine 179 (5): 375–82. https://doi.org/10.1164/rccm.200810-1540OC.
- Chicago author-date (all authors)
- VAN DURME, YANNICK, Katia Verhamme, Albert-Jan Aarnoudse, Geert Van Pottelberge, Albert Hofman, Jacqueline Witteman, Guy Joos, Guy Brusselle, and Bruno Stricker. 2009. “C-Reactive Protein Levels, Haplotypes and the Risk of Incident Chronic Obstructive Pulmonary Disease.” American Journal of Respiratory Critical Care Medicine 179 (5): 375–382. doi:10.1164/rccm.200810-1540OC.
- Vancouver
- 1.VAN DURME Y, Verhamme K, Aarnoudse A-J, Van Pottelberge G, Hofman A, Witteman J, et al. C-reactive protein levels, haplotypes and the risk of incident chronic obstructive pulmonary disease. American Journal of Respiratory Critical Care Medicine. 2009;179(5):375–82.
- IEEE
- [1]Y. VAN DURME et al., “C-reactive protein levels, haplotypes and the risk of incident chronic obstructive pulmonary disease,” American Journal of Respiratory Critical Care Medicine, vol. 179, no. 5, pp. 375–382, 2009.
@article{538272, abstract = {{Rationale Chronic obstructive pulmonary disease (COPD) is characterized by substantial chronic inflammation in the pulmonary compartment as well as in the systemic circulation. Objectives: To investigate potentially causal association, we examined whether serum levels of high-sensitivity C-reactive protein (hsCRP) and variations in the CRP gene are associated with the risk of developing COPD. Methods: This study is part of the Rotterdam Study, a prospective population-based cohort study among subjects aged 55 years or older. At baseline, 6,836 subjects without COPD had a blood sample available for assessment of hsCRP serum levels and haplotypes of the CRP gene. We analyzed the association between hsCRP levels, CRIP gene haplotypes, and incident COPD with Cox proportional hazard models, adjusted for age, sex, and other confounders. Measurements and Main Results: High levels of hsCRP (>3 mg/L) were associated with a significantly increased risk of incident COPD (hazard ratio [HR], 1.7; 95% confidence interval [CI], 1.16-2.49) compared with persons with low levels (< 1 mg/L). The risk remained increased after adjusting for potential confounders and introducing a latency period of 3 years. The risk was most pronounced in former smokers (HR, 2.2; 95% CI, 1.12-3.74). hsCRP was not a risk factor in never smokers. No CRP single nucleoticle polymorphism or haplotype was associated with a significantly increased or decreased COPD risk. Conclusions: Increased hsCRP levels are predictive for the occurrence of COPD in smokers. However, haplotypes of the CRP gene, which influence hsCRP levels, are not associated with an altered risk of developing COPD.}}, author = {{VAN DURME, YANNICK and Verhamme, Katia and Aarnoudse, Albert-Jan and Van Pottelberge, Geert and Hofman, Albert and Witteman, Jacqueline and Joos, Guy and Brusselle, Guy and Stricker, Bruno}}, issn = {{1073-449X}}, journal = {{American Journal of Respiratory Critical Care Medicine}}, keywords = {{C-reactive protein,Chronic obstructive pulmonary disease,genetics epidemiology}}, language = {{eng}}, number = {{5}}, pages = {{375--382}}, publisher = {{Amer Thoracic Soc}}, title = {{C-reactive protein levels, haplotypes and the risk of incident chronic obstructive pulmonary disease}}, url = {{http://doi.org/10.1164/rccm.200810-1540OC}}, volume = {{179}}, year = {{2009}}, }
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