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Stability of selected chlorinated thiazide diuretics

Koen Deventer UGent, GEERT BAELE UGent, Peter Van Eenoo UGent, Oscar Juan Pozo Mendoza UGent and Frans Delbeke UGent (2009) JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 49(2). p.519-524
abstract
In sports, diuretics are used for two main reasons: to flush previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. A common property observed for thiazides is hydrolysis in aqueous media resulting in the formation of the degradation product aminobenzenedisulphonamide. This degradation product can be observed for several thiazides. Because there is limited information regarding the effect of pH, temperature and light on the stability of thiazides, these parameters were investigated for chlorothiaizide, hydrochlorothiazide and altizide. For all three compounds the degradation product could be detected after incubation at pH 9.5 for 48 h at 60 degrees C. At lower pH and temperature the degradation product could not be detected for all compounds. When samples were exposed to UV-light altizide and hydrochlorothiazide were photodegraded to chlorothiazide. When the degradation rate between the different compounds was compared for a given temperature and pH, altizide is the most unstable compound. This study confirms that thiazide degradation products can be formed in urine during transport. Hence doping control laboratories shall include them into their routine testing methods as required by WADA. (C) 2008 Elsevier B.V. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Urine, Stability-study, CHROMATOGRAPHY-MASS-SPECTROMETRY, Thiazides, Diuretics, DOPING CONTROL, Doping, AGENTS, URINE, Sports
journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
J. Pharm. Biomed. Anal.
volume
49
issue
2
pages
519 - 524
Web of Science type
Article
Web of Science id
000263434900049
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
2.453 (2009)
JCR rank
23/70 (2009)
JCR quartile
2 (2009)
ISSN
0731-7085
DOI
10.1016/j.jpba.2008.11.001
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
536625
handle
http://hdl.handle.net/1854/LU-536625
date created
2009-04-02 09:04:40
date last changed
2010-08-16 11:18:53
@article{536625,
  abstract     = {In sports, diuretics are used for two main reasons: to flush previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. A common property observed for thiazides is hydrolysis in aqueous media resulting in the formation of the degradation product aminobenzenedisulphonamide. This degradation product can be observed for several thiazides. Because there is limited information regarding the effect of pH, temperature and light on the stability of thiazides, these parameters were investigated for chlorothiaizide, hydrochlorothiazide and altizide. For all three compounds the degradation product could be detected after incubation at pH 9.5 for 48 h at 60 degrees C. At lower pH and temperature the degradation product could not be detected for all compounds. When samples were exposed to UV-light altizide and hydrochlorothiazide were photodegraded to chlorothiazide. When the degradation rate between the different compounds was compared for a given temperature and pH, altizide is the most unstable compound. This study confirms that thiazide degradation products can be formed in urine during transport. Hence doping control laboratories shall include them into their routine testing methods as required by WADA. (C) 2008 Elsevier B.V. All rights reserved.},
  author       = {Deventer, Koen and BAELE, GEERT and Van Eenoo, Peter and Pozo Mendoza, Oscar Juan and Delbeke, Frans},
  issn         = {0731-7085},
  journal      = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS},
  keyword      = {Urine,Stability-study,CHROMATOGRAPHY-MASS-SPECTROMETRY,Thiazides,Diuretics,DOPING CONTROL,Doping,AGENTS,URINE,Sports},
  language     = {eng},
  number       = {2},
  pages        = {519--524},
  title        = {Stability of selected chlorinated thiazide diuretics},
  url          = {http://dx.doi.org/10.1016/j.jpba.2008.11.001},
  volume       = {49},
  year         = {2009},
}

Chicago
Deventer, Koen, GEERT BAELE, Peter Van Eenoo, Oscar Juan Pozo Mendoza, and Frans Delbeke. 2009. “Stability of Selected Chlorinated Thiazide Diuretics.” Journal of Pharmaceutical and Biomedical Analysis 49 (2): 519–524.
APA
Deventer, K., BAELE, G., Van Eenoo, P., Pozo Mendoza, O. J., & Delbeke, F. (2009). Stability of selected chlorinated thiazide diuretics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 49(2), 519–524.
Vancouver
1.
Deventer K, BAELE G, Van Eenoo P, Pozo Mendoza OJ, Delbeke F. Stability of selected chlorinated thiazide diuretics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2009;49(2):519–24.
MLA
Deventer, Koen, GEERT BAELE, Peter Van Eenoo, et al. “Stability of Selected Chlorinated Thiazide Diuretics.” JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 49.2 (2009): 519–524. Print.