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Evaluation of an injectable, photopolymerizable, and three-dimensional scaffold based on methacrylate-endcapped poly(D,L-lactide-co-ε-caprolactone) combined with autologous mesenchymal stem cells in a goat tibial unicortical defect model

Geert Vertenten UGent, Evi Lippens UGent, Jordi Gironès Molera UGent, Tomasz Gorski, Heidi Declercq UGent, Jimmy Saunders UGent, Wim Van Den Broeck UGent, Koen Chiers UGent, Luc Duchateau UGent and Etienne Schacht UGent, et al. (2009) TISSUE ENGINEERING PART A. 15(7). p.1501-1511
abstract
An in situ crosslinkable, biodegradable, methacrylate-endcapped poly(D,L-lactide-co-epsilon-caprolactone) in which crosslinkage is achieved by photoinitiators was developed for bone tissue regeneration. Different combinations of the polymer with bone marrow-derived mesenchymal stem cells (BMSCs) and alpha-tricalcium phosphate (alpha-TCP) were tested in a unicortical tibial defect model in eight goats. The polymers were randomly applied in one of three defects (6.0 mm diameter) using a fourth unfilled defect as control. Biocompatibility and bone-healing characteristics were evaluated by serial radiographies, histology, histomorphometry, and immunohistochemistry. The results demonstrated cell survival and proliferation in the polymer-substituted bone defects. The addition of alpha-TCP was associated with less expansion and growth of the BMSCs than other polymer composites.
Please use this url to cite or link to this publication:
author
organization
alternative title
Evaluation of an injectable, photopolymerizable, and three-dimensional scaffold based on methacrylate-endcapped poly(D,L-lactide-co-epsilon-caprolactone) combined with autologous mesenchymal stem cells in a goat tibial unicortical defect model
year
type
journalArticle (original)
publication status
published
subject
keyword
NETWORKS, MICROCARRIERS, CHONDROGENESIS, REPAIR, HYDROGEL, TRICALCIUM PHOSPHATE, SEGMENTAL DEFECT, TISSUE-ENGINEERED BONE, EPSILON-CAPROLACTONE, MARROW STROMAL CELLS
journal title
TISSUE ENGINEERING PART A
Tissue Eng. Part A
volume
15
issue
7
pages
1501 - 1511
Web of Science type
Article
Web of Science id
000267843700007
ISSN
1937-3341
DOI
10.1089/ten.tea.2008.0367
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
534488
handle
http://hdl.handle.net/1854/LU-534488
date created
2009-03-30 16:29:46
date last changed
2012-10-26 16:01:38
@article{534488,
  abstract     = {An in situ crosslinkable, biodegradable, methacrylate-endcapped poly(D,L-lactide-co-epsilon-caprolactone) in which crosslinkage is achieved by photoinitiators was developed for bone tissue regeneration. Different combinations of the polymer with bone marrow-derived mesenchymal stem cells (BMSCs) and alpha-tricalcium phosphate (alpha-TCP) were tested in a unicortical tibial defect model in eight goats. The polymers were randomly applied in one of three defects (6.0 mm diameter) using a fourth unfilled defect as control. Biocompatibility and bone-healing characteristics were evaluated by serial radiographies, histology, histomorphometry, and immunohistochemistry. The results demonstrated cell survival and proliferation in the polymer-substituted bone defects. The addition of alpha-TCP was associated with less expansion and growth of the BMSCs than other polymer composites.},
  author       = {Vertenten, Geert and Lippens, Evi and Giron{\`e}s Molera, Jordi and Gorski, Tomasz and Declercq, Heidi and Saunders, Jimmy and Van Den Broeck, Wim and Chiers, Koen and Duchateau, Luc and Schacht, Etienne and Cornelissen, Maria and Gasthuys, Frank and Vlaminck, Lieven},
  issn         = {1937-3341},
  journal      = {TISSUE ENGINEERING PART A},
  keyword      = {NETWORKS,MICROCARRIERS,CHONDROGENESIS,REPAIR,HYDROGEL,TRICALCIUM PHOSPHATE,SEGMENTAL DEFECT,TISSUE-ENGINEERED BONE,EPSILON-CAPROLACTONE,MARROW STROMAL CELLS},
  language     = {eng},
  number       = {7},
  pages        = {1501--1511},
  title        = {Evaluation of an injectable, photopolymerizable, and three-dimensional scaffold based on methacrylate-endcapped poly(D,L-lactide-co-\ensuremath{\epsilon}-caprolactone) combined with autologous mesenchymal stem cells in a goat tibial unicortical defect model},
  url          = {http://dx.doi.org/10.1089/ten.tea.2008.0367},
  volume       = {15},
  year         = {2009},
}

Chicago
Vertenten, Geert, Evi Lippens, Jordi Gironès Molera, Tomasz Gorski, Heidi Declercq, Jimmy Saunders, Wim Van Den Broeck, et al. 2009. “Evaluation of an Injectable, Photopolymerizable, and Three-dimensional Scaffold Based on Methacrylate-endcapped poly(D,L-lactide-co-ε-caprolactone) Combined with Autologous Mesenchymal Stem Cells in a Goat Tibial Unicortical Defect Model.” Tissue Engineering Part A 15 (7): 1501–1511.
APA
Vertenten, G., Lippens, E., Gironès Molera, J., Gorski, T., Declercq, H., Saunders, J., Van Den Broeck, W., et al. (2009). Evaluation of an injectable, photopolymerizable, and three-dimensional scaffold based on methacrylate-endcapped poly(D,L-lactide-co-ε-caprolactone) combined with autologous mesenchymal stem cells in a goat tibial unicortical defect model. TISSUE ENGINEERING PART A, 15(7), 1501–1511.
Vancouver
1.
Vertenten G, Lippens E, Gironès Molera J, Gorski T, Declercq H, Saunders J, et al. Evaluation of an injectable, photopolymerizable, and three-dimensional scaffold based on methacrylate-endcapped poly(D,L-lactide-co-ε-caprolactone) combined with autologous mesenchymal stem cells in a goat tibial unicortical defect model. TISSUE ENGINEERING PART A. 2009;15(7):1501–11.
MLA
Vertenten, Geert, Evi Lippens, Jordi Gironès Molera, et al. “Evaluation of an Injectable, Photopolymerizable, and Three-dimensional Scaffold Based on Methacrylate-endcapped poly(D,L-lactide-co-ε-caprolactone) Combined with Autologous Mesenchymal Stem Cells in a Goat Tibial Unicortical Defect Model.” TISSUE ENGINEERING PART A 15.7 (2009): 1501–1511. Print.