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Cellular uptake of soy-derived phytoestrogens in vitro and in human whole blood

Julie Maubach, Marc Bracke UGent, Herman Depypere UGent, Denis De Keukeleire UGent and Arne Heyerick UGent (2008) Journal of Pre-Clinical and Clinical Research. 2(1). p.64-70
abstract
Epidemiological studies comparing typical Western and traditional Eastern lifestyles indicate that dietary intake of soyderived phytoestrogens, including genistein, daidzein, and equol, may have significant health protective effects on hormone-dependent cancers, osteoporosis and cardiovascular diseases. Phytoestrogens have been demonstrated to exert varying effects depending on tissue, endogenous hormone concentrations, and receptor types. Thus, a detailed understanding of the biodistribution and bioavailability of specific phytoestrogens is required in order to predict the subsequent biologic activities. In this study we aimed to investigate the cellular uptake of these soy-derived phytoestrogens in different cell types, including the mammary MCF-7/6 and MDAB-MB 231 cell lines, the ovarian Ishikawa Var-I cell lines and in murine adipocyte clusters. Furthermore, the biodistribution between serum and cell fraction was also investigated in human whole blood. Equol generally shows a higher cellular uptake when compared with genistein and daidzein. Therefore, equol may be more potent with respect to its relative bioactivity, which is corroborated by the observations of specific health effects associated with the equol-producer phenotype.
Please use this url to cite or link to this publication:
author
organization
alternative title
Cellular uptake of soy-derived estrogens in vitro and in vivo
year
type
journalArticle (original)
publication status
published
subject
keyword
soy, genistein, phytoestrogens, equol, cellular uptake, biodistribution, daidzein
journal title
Journal of Pre-Clinical and Clinical Research
JPCCR
editor
Rafal Filip, Tadeusz Studzinski and Leszek Wdowiak
volume
2
issue
1
pages
64 - 70
publisher
Institute of Agricultural Medicine
place of publication
Lublin, Poland
ISSN
1898-2395
language
English
UGent publication?
yes
classification
A2
id
530862
handle
http://hdl.handle.net/1854/LU-530862
alternative location
http://www.jpccr.eu/archive_pdf/2008_vol_2_nr_1/14_Maubach_et_al.pdf
date created
2009-03-25 16:48:07
date last changed
2009-03-30 13:29:57
@article{530862,
  abstract     = {Epidemiological studies comparing typical Western and traditional Eastern lifestyles indicate that dietary intake of soyderived phytoestrogens, including genistein, daidzein, and equol, may have significant health protective effects on
hormone-dependent cancers, osteoporosis and cardiovascular diseases. Phytoestrogens have been demonstrated to exert varying effects depending on tissue, endogenous hormone concentrations, and receptor types. Thus, a detailed understanding of the biodistribution and bioavailability of specific phytoestrogens is required in order to predict the subsequent biologic activities. In this study we aimed to investigate the cellular uptake of these soy-derived
phytoestrogens in different cell types, including the mammary MCF-7/6 and MDAB-MB 231 cell lines, the ovarian
Ishikawa Var-I cell lines and in murine adipocyte clusters. Furthermore, the biodistribution between serum and cell
fraction was also investigated in human whole blood. Equol generally shows a higher cellular uptake when compared
with genistein and daidzein. Therefore, equol may be more potent with respect to its relative bioactivity, which is
corroborated by the observations of specific health effects associated with the equol-producer phenotype.},
  author       = {Maubach, Julie and Bracke, Marc and Depypere, Herman and De Keukeleire, Denis and Heyerick, Arne},
  editor       = {Filip, Rafal and Studzinski, Tadeusz and Wdowiak, Leszek},
  issn         = {1898-2395},
  journal      = {Journal of Pre-Clinical and Clinical Research},
  keyword      = {soy,genistein,phytoestrogens,equol,cellular uptake,biodistribution,daidzein},
  language     = {eng},
  number       = {1},
  pages        = {64--70},
  publisher    = {Institute of Agricultural Medicine},
  title        = {Cellular uptake of soy-derived phytoestrogens in vitro and in human whole blood},
  url          = {http://www.jpccr.eu/archive\_pdf/2008\_vol\_2\_nr\_1/14\_Maubach\_et\_al.pdf},
  volume       = {2},
  year         = {2008},
}

Chicago
Maubach, Julie, Marc Bracke, Herman Depypere, Denis De Keukeleire, and Arne Heyerick. 2008. “Cellular Uptake of Soy-derived Phytoestrogens in Vitro and in Human Whole Blood.” Ed. Rafal Filip, Tadeusz Studzinski, and Leszek Wdowiak. Journal of Pre-Clinical and Clinical Research 2 (1): 64–70.
APA
Maubach, J., Bracke, M., Depypere, H., De Keukeleire, D., & Heyerick, A. (2008). Cellular uptake of soy-derived phytoestrogens in vitro and in human whole blood. (R. Filip, T. Studzinski, & L. Wdowiak, Eds.)Journal of Pre-Clinical and Clinical Research, 2(1), 64–70.
Vancouver
1.
Maubach J, Bracke M, Depypere H, De Keukeleire D, Heyerick A. Cellular uptake of soy-derived phytoestrogens in vitro and in human whole blood. Filip R, Studzinski T, Wdowiak L, editors. Journal of Pre-Clinical and Clinical Research. Lublin, Poland: Institute of Agricultural Medicine; 2008;2(1):64–70.
MLA
Maubach, Julie, Marc Bracke, Herman Depypere, et al. “Cellular Uptake of Soy-derived Phytoestrogens in Vitro and in Human Whole Blood.” Ed. Rafal Filip, Tadeusz Studzinski, & Leszek Wdowiak. Journal of Pre-Clinical and Clinical Research 2.1 (2008): 64–70. Print.