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Human mast cells express leptin and leptin receptors

Jasmien Taildeman UGent, Claudina Perez Novo UGent, Isabelle Rottiers UGent, Liesbeth Ferdinande UGent, Anouk Waeytens UGent, Veerle De Colvenaer UGent, Claus Bachert UGent, Pieter Demetter, Wim Waelput UGent and Katleen Braet, et al. (2009) Histochemistry and Cell Biology. 131(6). p.703-711
abstract
Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. Immunohistochemical and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and several parts of the respiratory, gastro-intestinal and urogenital tract. Leptin was expressed in mast cells expressing the classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors, the expression pattern was tissue dependent and not related to tryptase or chymase expression. Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
mast cell phenotypes, leptin receptor, leptin, mast cell
journal title
Histochemistry and Cell Biology
Histochem. Cell Biol.
volume
131
issue
6
pages
703 - 711
Web of Science type
Article
Web of Science id
000266261500004
JCR category
MICROSCOPY
JCR impact factor
3.021 (2009)
JCR rank
2/9 (2009)
JCR quartile
1 (2009)
ISSN
0948-6143
DOI
10.1007/s00418-009-0575-3
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
530495
handle
http://hdl.handle.net/1854/LU-530495
date created
2009-03-25 14:40:37
date last changed
2010-03-31 11:06:35
@article{530495,
  abstract     = {Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. 
Immunohistochemical and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and several parts of the respiratory, gastro-intestinal and urogenital tract. Leptin was expressed in mast cells expressing the classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors, the expression pattern was tissue dependent and not related to tryptase or chymase expression.  
Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.},
  author       = {Taildeman, Jasmien and Perez Novo, Claudina and Rottiers, Isabelle and Ferdinande, Liesbeth and Waeytens, Anouk and De Colvenaer, Veerle and Bachert, Claus and Demetter, Pieter and Waelput, Wim and Braet, Katleen and Cuvelier, Claude},
  issn         = {0948-6143},
  journal      = {Histochemistry and Cell Biology},
  keyword      = {mast cell phenotypes,leptin receptor,leptin,mast cell},
  language     = {eng},
  number       = {6},
  pages        = {703--711},
  title        = {Human mast cells express leptin and leptin receptors},
  url          = {http://dx.doi.org/10.1007/s00418-009-0575-3},
  volume       = {131},
  year         = {2009},
}

Chicago
Taildeman, Jasmien, Claudina Perez Novo, ISABELLE ROTTIERS, Liesbeth Ferdinande, Anouk Waeytens, Veerle De Colvenaer, Claus Bachert, et al. 2009. “Human Mast Cells Express Leptin and Leptin Receptors.” Histochemistry and Cell Biology 131 (6): 703–711.
APA
Taildeman, J., Perez Novo, C., ROTTIERS, I., Ferdinande, L., Waeytens, A., De Colvenaer, V., Bachert, C., et al. (2009). Human mast cells express leptin and leptin receptors. Histochemistry and Cell Biology, 131(6), 703–711.
Vancouver
1.
Taildeman J, Perez Novo C, ROTTIERS I, Ferdinande L, Waeytens A, De Colvenaer V, et al. Human mast cells express leptin and leptin receptors. Histochemistry and Cell Biology. 2009;131(6):703–11.
MLA
Taildeman, Jasmien, Claudina Perez Novo, ISABELLE ROTTIERS, et al. “Human Mast Cells Express Leptin and Leptin Receptors.” Histochemistry and Cell Biology 131.6 (2009): 703–711. Print.