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Human mast cells express leptin and leptin receptors

(2009) Histochemistry and Cell Biology. 131(6). p.703-711
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Abstract
Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. Immunohistochemical and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and several parts of the respiratory, gastro-intestinal and urogenital tract. Leptin was expressed in mast cells expressing the classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors, the expression pattern was tissue dependent and not related to tryptase or chymase expression. Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.
Keywords
mast cell phenotypes, leptin receptor, leptin, mast cell

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Chicago
Taildeman, Jasmien, Claudina Perez Novo, Isabelle Rottiers, Liesbeth Ferdinande, Anouk Waeytens, Veerle De Colvenaer, Claus Bachert, et al. 2009. “Human Mast Cells Express Leptin and Leptin Receptors.” Histochemistry and Cell Biology 131 (6): 703–711.
APA
Taildeman, J., Perez Novo, C., Rottiers, I., Ferdinande, L., Waeytens, A., De Colvenaer, V., Bachert, C., et al. (2009). Human mast cells express leptin and leptin receptors. Histochemistry and Cell Biology, 131(6), 703–711.
Vancouver
1.
Taildeman J, Perez Novo C, Rottiers I, Ferdinande L, Waeytens A, De Colvenaer V, et al. Human mast cells express leptin and leptin receptors. Histochemistry and Cell Biology. 2009;131(6):703–11.
MLA
Taildeman, Jasmien, Claudina Perez Novo, Isabelle Rottiers, et al. “Human Mast Cells Express Leptin and Leptin Receptors.” Histochemistry and Cell Biology 131.6 (2009): 703–711. Print.
@article{530495,
  abstract     = {Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. 
Immunohistochemical and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and several parts of the respiratory, gastro-intestinal and urogenital tract. Leptin was expressed in mast cells expressing the classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors, the expression pattern was tissue dependent and not related to tryptase or chymase expression.  
Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.},
  author       = {Taildeman, Jasmien and Perez Novo, Claudina and Rottiers, Isabelle and Ferdinande, Liesbeth and Waeytens, Anouk and De Colvenaer, Veerle and Bachert, Claus and Demetter, Pieter and Waelput, Wim and Braet, Katleen and Cuvelier, Claude},
  issn         = {0948-6143},
  journal      = {Histochemistry and Cell Biology},
  keyword      = {mast cell phenotypes,leptin receptor,leptin,mast cell},
  language     = {eng},
  number       = {6},
  pages        = {703--711},
  title        = {Human mast cells express leptin and leptin receptors},
  url          = {http://dx.doi.org/10.1007/s00418-009-0575-3},
  volume       = {131},
  year         = {2009},
}

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