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Evaluation of the brain 5-HT2A receptor binding index in dogs with anxiety disorders, measured with I-123-5I-R91150 and SPECT

Simon Vermeire UGent, Kurt Audenaert UGent, André Dobbeleir, Rudy De Meester UGent, Filip De Vos UGent and Kathelijne Peremans UGent (2009) JOURNAL OF NUCLEAR MEDICINE. 50(2). p.284-289
abstract
The serotonergic system has been implicated in emotional and cognitive functions since early work. In particular, an important role has been attributed to the 5-HT2A receptor in schizophrenia, depression, eating disorders, and anxiety. The aim of the study was to evaluate the involvement of the brain 5-HT2A receptor in dogs with severe anxiety disorder, using I-123-5I-R91150 and SPECT. Methods: SPECT was performed with the 5-HT2A receptor-specific radioligand I-123-5I-R91150 to determine the 5-HT2A receptor binding index (131) in the brains of dogs. Sixteen dogs with pathologic anxiety problems were compared with 22 normal-behaving reference dogs. Results: Lower 5-HT2A receptor BI was found in the left (P = 0.001) and right (P = 0.002) frontal cortices in the group of dogs with anxiety disorders than in the reference group. Right (P = 0.022) and left (P = 0.048) temporocortical BIs were also significantly lower in the dogs with anxiety disorders. Finally, the BI was significantly lower in the right occipital cortex (P = 0.038) of dogs with anxiety disorders than in the reference dogs. After correction for multiple comparisons (P < 0.0056), only the bilateral frontocortical lower BI remained significant. Conclusion: The findings in this study indicate that the 5-HT2A receptor is involved in the pathophysiology of anxiety disorders in dogs. The affected brain regions are in concordance with the brain regions involved in human anxiety disorders. The acquired data confirm the potential of using the dog as a natural model for investigation of the different mechanisms of anxiety disorders. In this regard, the use of dogs may contribute to the development of novel treatment approaches and new drugs for veterinary and human use.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SPECT, anxiety disorders, serotonin (5-HT), 5-HT2A receptor, dog, SEROTONIN REUPTAKE INHIBITOR, CEREBRAL-BLOOD-FLOW, EMISSION-TOMOGRAPHY, PANIC DISORDER, MAJOR DEPRESSION, I-123-5-I-R91150, TRAITS, CORTEX, NOREPINEPHRINE, ANTAGONIST
journal title
JOURNAL OF NUCLEAR MEDICINE
J. Nucl. Med.
volume
50
issue
2
pages
284 - 289
Web of Science type
Article
Web of Science id
000263487800034
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
6.424 (2009)
JCR rank
1/104 (2009)
JCR quartile
4 (2009)
ISSN
0161-5505
DOI
10.2967/jnumed.108.055731
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
529430
handle
http://hdl.handle.net/1854/LU-529430
date created
2009-03-24 14:52:32
date last changed
2011-05-09 14:25:46
@article{529430,
  abstract     = {The serotonergic system has been implicated in emotional and cognitive functions since early work. In particular, an important role has been attributed to the 5-HT2A receptor in schizophrenia, depression, eating disorders, and anxiety. The aim of the study was to evaluate the involvement of the brain 5-HT2A receptor in dogs with severe anxiety disorder, using I-123-5I-R91150 and SPECT. Methods: SPECT was performed with the 5-HT2A receptor-specific radioligand I-123-5I-R91150 to determine the 5-HT2A receptor binding index (131) in the brains of dogs. Sixteen dogs with pathologic anxiety problems were compared with 22 normal-behaving reference dogs. Results: Lower 5-HT2A receptor BI was found in the left (P = 0.001) and right (P = 0.002) frontal cortices in the group of dogs with anxiety disorders than in the reference group. Right (P = 0.022) and left (P = 0.048) temporocortical BIs were also significantly lower in the dogs with anxiety disorders. Finally, the BI was significantly lower in the right occipital cortex (P = 0.038) of dogs with anxiety disorders than in the reference dogs. After correction for multiple comparisons (P {\textlangle} 0.0056), only the bilateral frontocortical lower BI remained significant. Conclusion: The findings in this study indicate that the 5-HT2A receptor is involved in the pathophysiology of anxiety disorders in dogs. The affected brain regions are in concordance with the brain regions involved in human anxiety disorders. The acquired data confirm the potential of using the dog as a natural model for investigation of the different mechanisms of anxiety disorders. In this regard, the use of dogs may contribute to the development of novel treatment approaches and new drugs for veterinary and human use.},
  author       = {Vermeire, Simon and Audenaert, Kurt and Dobbeleir, Andr{\'e} and De Meester, Rudy and De Vos, Filip and Peremans, Kathelijne},
  issn         = {0161-5505},
  journal      = {JOURNAL OF NUCLEAR MEDICINE},
  keyword      = {SPECT,anxiety disorders,serotonin (5-HT),5-HT2A receptor,dog,SEROTONIN REUPTAKE INHIBITOR,CEREBRAL-BLOOD-FLOW,EMISSION-TOMOGRAPHY,PANIC DISORDER,MAJOR DEPRESSION,I-123-5-I-R91150,TRAITS,CORTEX,NOREPINEPHRINE,ANTAGONIST},
  language     = {eng},
  number       = {2},
  pages        = {284--289},
  title        = {Evaluation of the brain 5-HT2A receptor binding index in dogs with anxiety disorders, measured with I-123-5I-R91150 and SPECT},
  url          = {http://dx.doi.org/10.2967/jnumed.108.055731},
  volume       = {50},
  year         = {2009},
}

Chicago
Vermeire, Simon, Kurt Audenaert, André Dobbeleir, Rudy De Meester, Filip De Vos, and Kathelijne Peremans. 2009. “Evaluation of the Brain 5-HT2A Receptor Binding Index in Dogs with Anxiety Disorders, Measured with I-123-5I-R91150 and SPECT.” Journal of Nuclear Medicine 50 (2): 284–289.
APA
Vermeire, Simon, Audenaert, K., Dobbeleir, A., De Meester, R., De Vos, F., & Peremans, K. (2009). Evaluation of the brain 5-HT2A receptor binding index in dogs with anxiety disorders, measured with I-123-5I-R91150 and SPECT. JOURNAL OF NUCLEAR MEDICINE, 50(2), 284–289.
Vancouver
1.
Vermeire S, Audenaert K, Dobbeleir A, De Meester R, De Vos F, Peremans K. Evaluation of the brain 5-HT2A receptor binding index in dogs with anxiety disorders, measured with I-123-5I-R91150 and SPECT. JOURNAL OF NUCLEAR MEDICINE. 2009;50(2):284–9.
MLA
Vermeire, Simon, Kurt Audenaert, André Dobbeleir, et al. “Evaluation of the Brain 5-HT2A Receptor Binding Index in Dogs with Anxiety Disorders, Measured with I-123-5I-R91150 and SPECT.” JOURNAL OF NUCLEAR MEDICINE 50.2 (2009): 284–289. Print.