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Expression of galectins-1,-3 and-4 varies with strain and type of experimental colitis in mice

Anne Mathieu, Nathalie Nagy, Christine Decaestecker, LIESBETH FERDINANDE UGent, Klaas Vandenbroucke, Pieter Rottiers, Claude Cuvelier UGent, Isabelle Salmon and Pieter Demetter (2008) INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. 89(6). p.438-446
abstract
Galectins are increasingly the focus of biomedical research. Although they are involved at different stages in inflammation, data on galectins in colitis remain scarce. The aim of this study was to determine and compare the expression of galectins in acute and chronic experimental colitis in mice. Immunohistochemistry for galectins-1, -3 and -4 was performed on colon tissue from C57BL/6 and BALB/c mice with acute dextran sodium sulphate colitis and from 129 Sv/Ev IL-10 knock-out (IL-10(-/-)) mice. From these three mouse strains, we first detected major differences in galectin expression related to the genetic background in the control animals. With regard to inflammation, chronic colitis in IL-10(-/-) mice was associated with increased galectin-4 expression; in contrast with the two other models, no galectin-1 and -3 alterations were observed in IL-10(-/-) mice. Acute colitis in C57BL/6 and BALB/c mice showed increased galectin-3 expression in the lamina propria and the crypt epithelium, together with a decreased nuclear expression. These results suggest an involvement of galectins in the development and perpetuation of colonic inflammation and illustrate that the choice of the mouse strain for studying galectins might influence the outcome of the experiments.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
T-CELLS, MOUSE, CARBOHYDRATE-BINDING PROTEIN-35, CHRONIC INTESTINAL INFLAMMATION, FAMILY, LECTIN, LOCALIZATION, HUMAN COLON-CANCER, CELL-MIGRATION, CROHNS-DISEASE
journal title
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
Int. J. Exp. Pathol.
volume
89
issue
6
pages
438 - 446
publisher
BLACKWELL PUBLISHING
place of publication
OXON, ENGLAND
Web of Science type
Article
Web of Science id
000260670300005
JCR category
PATHOLOGY
JCR impact factor
2.202 (2008)
JCR rank
30/68 (2008)
JCR quartile
2 (2008)
ISSN
0959-9673
DOI
10.1111/J.1365-2613.2008.00598.X
language
English
UGent publication?
yes
classification
A1
id
527471
handle
http://hdl.handle.net/1854/LU-527471
date created
2009-03-23 09:01:23
date last changed
2009-03-25 14:11:41
@article{527471,
  abstract     = {Galectins are increasingly the focus of biomedical research. Although they are involved at different stages in inflammation, data on galectins in colitis remain scarce. The aim of this study was to determine and compare the expression of galectins in acute and chronic experimental colitis in mice. Immunohistochemistry for galectins-1, -3 and -4 was performed on colon tissue from C57BL/6 and BALB/c mice with acute dextran sodium sulphate colitis and from 129 Sv/Ev IL-10 knock-out (IL-10(-/-)) mice. From these three mouse strains, we first detected major differences in galectin expression related to the genetic background in the control animals. With regard to inflammation, chronic colitis in IL-10(-/-) mice was associated with increased galectin-4 expression; in contrast with the two other models, no galectin-1 and -3 alterations were observed in IL-10(-/-) mice. Acute colitis in C57BL/6 and BALB/c mice showed increased galectin-3 expression in the lamina propria and the crypt epithelium, together with a decreased nuclear expression. These results suggest an involvement of galectins in the development and perpetuation of colonic inflammation and illustrate that the choice of the mouse strain for studying galectins might influence the outcome of the experiments.},
  author       = {Mathieu, Anne and Nagy, Nathalie and Decaestecker, Christine and FERDINANDE, LIESBETH and Vandenbroucke, Klaas and Rottiers, Pieter and Cuvelier, Claude and Salmon, Isabelle and Demetter, Pieter},
  issn         = {0959-9673},
  journal      = {INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY},
  keyword      = {T-CELLS,MOUSE,CARBOHYDRATE-BINDING PROTEIN-35,CHRONIC INTESTINAL INFLAMMATION,FAMILY,LECTIN,LOCALIZATION,HUMAN COLON-CANCER,CELL-MIGRATION,CROHNS-DISEASE},
  language     = {eng},
  number       = {6},
  pages        = {438--446},
  publisher    = {BLACKWELL PUBLISHING},
  title        = {Expression of galectins-1,-3 and-4 varies with strain and type of experimental colitis in mice},
  url          = {http://dx.doi.org/10.1111/J.1365-2613.2008.00598.X},
  volume       = {89},
  year         = {2008},
}

Chicago
Mathieu, Anne, Nathalie Nagy, Christine Decaestecker, Liesbeth Ferdinande, Klaas Vandenbroucke, Pieter Rottiers, Claude Cuvelier, Isabelle Salmon, and Pieter Demetter. 2008. “Expression of Galectins-1,-3 and-4 Varies with Strain and Type of Experimental Colitis in Mice.” International Journal of Experimental Pathology 89 (6): 438–446.
APA
Mathieu, A., Nagy, N., Decaestecker, C., Ferdinande, L., Vandenbroucke, K., Rottiers, P., Cuvelier, C., et al. (2008). Expression of galectins-1,-3 and-4 varies with strain and type of experimental colitis in mice. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 89(6), 438–446.
Vancouver
1.
Mathieu A, Nagy N, Decaestecker C, Ferdinande L, Vandenbroucke K, Rottiers P, et al. Expression of galectins-1,-3 and-4 varies with strain and type of experimental colitis in mice. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. OXON, ENGLAND: BLACKWELL PUBLISHING; 2008;89(6):438–46.
MLA
Mathieu, Anne, Nathalie Nagy, Christine Decaestecker, et al. “Expression of Galectins-1,-3 and-4 Varies with Strain and Type of Experimental Colitis in Mice.” INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 89.6 (2008): 438–446. Print.