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Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies

(2008) Vaccine. 26. p.6503-6507
Author
Organization
Abstract
The extracellular domain of influenza A virus matrix protein 2 (M2e) is strongly conserved. Therefore, vaccines based on M2e can induce broad-spectrum immunity against influenza. We have mainly used recombinant virus-like particles derived fromHepatitis B virus core (HBc) as carrier for efficacious presentation of the M2e antigen. Here, we address whether pre-existing HBc-specific immunity interferes with the protective immune response obtained by M2e-HBc vaccination. Anti-HBc antibodieswere induced by immunizing mice with unsubstituted HBc virus-like particles in the presence of two different adjuvants. We demonstrate that pre-existing HBc-specific antibodies affect neither the induction of M2e-specific antibody responses to vaccination with M2e-HBc particles, nor the protective efficacy of the resulting response. These results suggest that vaccination with M2e-HBc can induce protective anti-M2e antibodies even in anti-HBc positive individuals. The implications of these findings are discussed in the context of the clinical development of an M2e-based universal influenza vaccine, which recently successfully completed a Phase I trial.

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Chicago
De Filette, Marina, Wouter Martens, Anouk Smet, Michael Schotsaert, Ashley Birkett, Patricia Londoño-Arcila, Walter Fiers, and Xavier Saelens. 2008. “Universal Influenza A M2e-HBc Vaccine Protects Against Disease Even in the Presence of Pre-existing anti-HBc Antibodies.” Vaccine 26: 6503–6507.
APA
De Filette, M., Martens, W., Smet, A., Schotsaert, M., Birkett, A., Londoño-Arcila, P., Fiers, W., et al. (2008). Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies. Vaccine, 26, 6503–6507.
Vancouver
1.
De Filette M, Martens W, Smet A, Schotsaert M, Birkett A, Londoño-Arcila P, et al. Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies. Vaccine. 2008;26:6503–7.
MLA
De Filette, Marina, Wouter Martens, Anouk Smet, et al. “Universal Influenza A M2e-HBc Vaccine Protects Against Disease Even in the Presence of Pre-existing anti-HBc Antibodies.” Vaccine 26 (2008): 6503–6507. Print.
@article{526195,
  abstract     = {The extracellular domain of influenza A virus matrix protein 2 (M2e) is strongly conserved. Therefore,
vaccines based on M2e can induce broad-spectrum immunity against influenza. We have mainly used
recombinant virus-like particles derived fromHepatitis B virus core (HBc) as carrier for efficacious presentation
of the M2e antigen. Here, we address whether pre-existing HBc-specific immunity interferes with
the protective immune response obtained by M2e-HBc vaccination. Anti-HBc antibodieswere induced by
immunizing mice with unsubstituted HBc virus-like particles in the presence of two different adjuvants.
We demonstrate that pre-existing HBc-specific antibodies affect neither the induction of M2e-specific
antibody responses to vaccination with M2e-HBc particles, nor the protective efficacy of the resulting
response. These results suggest that vaccination with M2e-HBc can induce protective anti-M2e antibodies
even in anti-HBc positive individuals. The implications of these findings are discussed in the context
of the clinical development of an M2e-based universal influenza vaccine, which recently successfully
completed a Phase I trial.},
  author       = {De Filette, Marina and Martens, Wouter and Smet, Anouk and Schotsaert, Michael and Birkett, Ashley and Londoño-Arcila, Patricia and Fiers, Walter and Saelens, Xavier},
  issn         = {0264-410X},
  journal      = {Vaccine},
  language     = {eng},
  pages        = {6503--6507},
  title        = {Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2008.09.038},
  volume       = {26},
  year         = {2008},
}

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