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Transsplenic portal catheterization combined with a jugular double-lumen catheter for pharmacokinetic and presystemic metabolization studies in pigs

Author
Organization
Abstract
The reliability of a silicone double-lumen catheter implanted into the external jugular vein and tunnelled towards the neck region was investigated in eight pigs. Surgery was uneventful without interference with the normal homoeostasis during 8 days. After injection of amoxicillin/clavulanic acid through the distal port of the catheter, analysis of drug components in the simultaneous blood samples obtained by the proximal port and a Venoject((R)) system were comparable in one pig. Histological control of the catheterized jugular veins pointed to an acceptable tissue reaction while bacteriological examination of the tip of the catheters was negative in only three animals. A moulding of the intestinal veins was made in a pig cadaver to determine the optimal length of insertion of a silicone portal catheter from the splenic vein towards the portal vein. Surgery was straightforward in four pigs whereby the catheter was exteriorized towards the back region. No complications were encountered during and after surgery for 9 days. The technique of a double-lumen catheter placed into the jugular vein and a transsplenic portal catheter is a useful tool for the study of the pharmacokinetics and also the first-pass effect of drugs in experimental pigs.
Keywords
CLAVULANIC ACID, INTRAVENOUS CATHETERIZATION, VEIN-CATHETERIZATION, CONSCIOUS SWINE, VASCULAR-ACCESS, HEPATIC VEIN, BLOOD, CANNULATION, AMOXICILLIN, COLLECTION

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MLA
Gasthuys, Frank, Sandra De Boever, Stijn Schauvliege, et al. “Transsplenic Portal Catheterization Combined with a Jugular Double-lumen Catheter for Pharmacokinetic and Presystemic Metabolization Studies in Pigs.” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 32.2 (2009): 137–145. Print.
APA
Gasthuys, F., De Boever, S., Schauvliege, S., Reyns, T., Levet, T., Cornillie, P., Casteleyn, C., et al. (2009). Transsplenic portal catheterization combined with a jugular double-lumen catheter for pharmacokinetic and presystemic metabolization studies in pigs. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 32(2), 137–145.
Chicago author-date
Gasthuys, Frank, Sandra De Boever, Stijn Schauvliege, Tim Reyns, Tamara Levet, Pieter Cornillie, Christophe Casteleyn, Patrick De Backer, and Siska Croubels. 2009. “Transsplenic Portal Catheterization Combined with a Jugular Double-lumen Catheter for Pharmacokinetic and Presystemic Metabolization Studies in Pigs.” Journal of Veterinary Pharmacology and Therapeutics 32 (2): 137–145.
Chicago author-date (all authors)
Gasthuys, Frank, Sandra De Boever, Stijn Schauvliege, Tim Reyns, Tamara Levet, Pieter Cornillie, Christophe Casteleyn, Patrick De Backer, and Siska Croubels. 2009. “Transsplenic Portal Catheterization Combined with a Jugular Double-lumen Catheter for Pharmacokinetic and Presystemic Metabolization Studies in Pigs.” Journal of Veterinary Pharmacology and Therapeutics 32 (2): 137–145.
Vancouver
1.
Gasthuys F, De Boever S, Schauvliege S, Reyns T, Levet T, Cornillie P, et al. Transsplenic portal catheterization combined with a jugular double-lumen catheter for pharmacokinetic and presystemic metabolization studies in pigs. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. 2009;32(2):137–45.
IEEE
[1]
F. Gasthuys et al., “Transsplenic portal catheterization combined with a jugular double-lumen catheter for pharmacokinetic and presystemic metabolization studies in pigs,” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, vol. 32, no. 2, pp. 137–145, 2009.
@article{525246,
  abstract     = {The reliability of a silicone double-lumen catheter implanted into the external jugular vein and tunnelled towards the neck region was investigated in eight pigs. Surgery was uneventful without interference with the normal homoeostasis during 8 days. After injection of amoxicillin/clavulanic acid through the distal port of the catheter, analysis of drug components in the simultaneous blood samples obtained by the proximal port and a Venoject((R)) system were comparable in one pig. Histological control of the catheterized jugular veins pointed to an acceptable tissue reaction while bacteriological examination of the tip of the catheters was negative in only three animals. A moulding of the intestinal veins was made in a pig cadaver to determine the optimal length of insertion of a silicone portal catheter from the splenic vein towards the portal vein. Surgery was straightforward in four pigs whereby the catheter was exteriorized towards the back region. No complications were encountered during and after surgery for 9 days. The technique of a double-lumen catheter placed into the jugular vein and a transsplenic portal catheter is a useful tool for the study of the pharmacokinetics and also the first-pass effect of drugs in experimental pigs.},
  author       = {Gasthuys, Frank and De Boever, Sandra and Schauvliege, Stijn and Reyns, Tim and Levet, Tamara and Cornillie, Pieter and Casteleyn, Christophe and De Backer, Patrick and Croubels, Siska},
  issn         = {0140-7783},
  journal      = {JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS},
  keywords     = {CLAVULANIC ACID,INTRAVENOUS CATHETERIZATION,VEIN-CATHETERIZATION,CONSCIOUS SWINE,VASCULAR-ACCESS,HEPATIC VEIN,BLOOD,CANNULATION,AMOXICILLIN,COLLECTION},
  language     = {eng},
  number       = {2},
  pages        = {137--145},
  title        = {Transsplenic portal catheterization combined with a jugular double-lumen catheter for pharmacokinetic and presystemic metabolization studies in pigs},
  url          = {http://dx.doi.org/10.1111/j.1365-2885.2008.01012.x},
  volume       = {32},
  year         = {2009},
}

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