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Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies

Stijn Schauvliege (UGent) , Annelies Van den Eede (UGent) , Luc Duchateau (UGent) and Frank Gasthuys (UGent)
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Abstract
Objective To evaluate the combined effects of enoximone and dobutamine on the cardiovascular system and respiratory gas exchange in isofluraneanaesthetized ponies. Study design Prospective, randomized, experimental study. Animals Six ponies (286 +/- 52 kg), aged 5.0 +/- 1.6 years. Methods After sedation (romifidine 80 mu g kg(-1)), anaesthesia was induced with midazolam (0.06 mg kg(-1)) and ketamine (2.2 mg kg(-1)) and maintained with isoflurane in oxygen. The ponies were ventilated to maintain eucapnia. After 90 minutes (= T0), enoximone alone (0.5 mg kg(-1)) ( E) or enoximone, followed by a constant rate infusion of dobutamine (0.5 mu g kg(-1) minute(-1)) (ED) for 120 minutes, was administered. Each pony received both treatments in a crossover trial, with at least 2 weeks between treatments. Heart rate (HR), cardiac output (CO), stroke volume (SV), right atrial (RAP), systolic ( SAP), diastolic (DAP) and mean arterial pressure ( MAP), blood gases, systemic vascular resistance (SVR), oxygen delivery (DO2) and several respiratory gas exchange variables were measured before treatment and until T120. Statistical analysis was based on a mixed model with treatment, time and their interaction as fixed categorical effects, pony as random effect, comparing treatments globally (alpha = 0.05) and at specific timepoints (Bonferroni-adjusted alpha = 0.00625). Results Compared to enoximone alone, ED treatment produced an increase in HR, CO, SV, RAP, SAP, DAP, MAP, packed cell volume (PCV) and DO2. The difference was significant from T60 to T120 (except at T80) for HR, throughout the observational period for CO, SAP, MAP, PCV and DO2, from T40 to T120 for DAP, at T10, T60, T80 and T120 for SV and at T10 and T20 for RAP. Overall decreases occurred in SVR and dead space ventilation (V-D/V-T). V-D/V-T was lower at T20 and from T80 to T120. Venous oxygen saturation was increased from T60 onwards. Conclusions and clinical relevance The results suggest that enoximone and dobutamine have additive cardiovascular effects and reduce V-D/V-T in isoflurane-anaesthetized ponies.
Keywords
dobutamine, cardiovascular depression, enoximone, horse, isoflurane

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MLA
Schauvliege, Stijn, Annelies Van den Eede, Luc Duchateau, et al. “Effects of Dobutamine on Cardiovascular Function and Respiratory Gas Exchange After Enoximone in Isoflurane-anaesthetized Ponies.” VETERINARY ANAESTHESIA AND ANALGESIA 35.4 (2008): 306–318. Print.
APA
Schauvliege, S., Van den Eede, A., Duchateau, L., & Gasthuys, F. (2008). Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies. VETERINARY ANAESTHESIA AND ANALGESIA, 35(4), 306–318.
Chicago author-date
Schauvliege, Stijn, Annelies Van den Eede, Luc Duchateau, and Frank Gasthuys. 2008. “Effects of Dobutamine on Cardiovascular Function and Respiratory Gas Exchange After Enoximone in Isoflurane-anaesthetized Ponies.” Veterinary Anaesthesia and Analgesia 35 (4): 306–318.
Chicago author-date (all authors)
Schauvliege, Stijn, Annelies Van den Eede, Luc Duchateau, and Frank Gasthuys. 2008. “Effects of Dobutamine on Cardiovascular Function and Respiratory Gas Exchange After Enoximone in Isoflurane-anaesthetized Ponies.” Veterinary Anaesthesia and Analgesia 35 (4): 306–318.
Vancouver
1.
Schauvliege S, Van den Eede A, Duchateau L, Gasthuys F. Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies. VETERINARY ANAESTHESIA AND ANALGESIA. 2008;35(4):306–18.
IEEE
[1]
S. Schauvliege, A. Van den Eede, L. Duchateau, and F. Gasthuys, “Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies,” VETERINARY ANAESTHESIA AND ANALGESIA, vol. 35, no. 4, pp. 306–318, 2008.
@article{525107,
  abstract     = {Objective To evaluate the combined effects of enoximone and dobutamine on the cardiovascular system and respiratory gas exchange in isofluraneanaesthetized ponies. Study design Prospective, randomized, experimental study. Animals Six ponies (286 +/- 52 kg), aged 5.0 +/- 1.6 years. Methods After sedation (romifidine 80 mu g kg(-1)), anaesthesia was induced with midazolam (0.06 mg kg(-1)) and ketamine (2.2 mg kg(-1)) and maintained with isoflurane in oxygen. The ponies were ventilated to maintain eucapnia. After 90 minutes (= T0), enoximone alone (0.5 mg kg(-1)) ( E) or enoximone, followed by a constant rate infusion of dobutamine (0.5 mu g kg(-1) minute(-1)) (ED) for 120 minutes, was administered. Each pony received both treatments in a crossover trial, with at least 2 weeks between treatments. Heart rate (HR), cardiac output (CO), stroke volume (SV), right atrial (RAP), systolic ( SAP), diastolic (DAP) and mean arterial pressure ( MAP), blood gases, systemic vascular resistance (SVR), oxygen delivery (DO2) and several respiratory gas exchange variables were measured before treatment and until T120. Statistical analysis was based on a mixed model with treatment, time and their interaction as fixed categorical effects, pony as random effect, comparing treatments globally (alpha = 0.05) and at specific timepoints (Bonferroni-adjusted alpha = 0.00625).
Results Compared to enoximone alone, ED treatment produced an increase in HR, CO, SV, RAP, SAP, DAP, MAP, packed cell volume (PCV) and DO2. The difference was significant from T60 to T120 (except at T80) for HR, throughout the observational period for CO, SAP, MAP, PCV and DO2, from T40 to T120 for DAP, at T10, T60, T80 and T120 for SV and at T10 and T20 for RAP. Overall decreases occurred in SVR and dead space ventilation (V-D/V-T). V-D/V-T was lower at T20 and from T80 to T120. Venous oxygen saturation was increased from T60 onwards.  Conclusions and clinical relevance The results suggest that enoximone and dobutamine have additive cardiovascular effects and reduce V-D/V-T in isoflurane-anaesthetized ponies.},
  author       = {Schauvliege, Stijn and Van den Eede, Annelies and Duchateau, Luc and Gasthuys, Frank},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keywords     = {dobutamine,cardiovascular depression,enoximone,horse,isoflurane},
  language     = {eng},
  number       = {4},
  pages        = {306--318},
  title        = {Effects of dobutamine on cardiovascular function and respiratory gas exchange after enoximone in isoflurane-anaesthetized ponies},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2007.00392.x},
  volume       = {35},
  year         = {2008},
}

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