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Origin of Clostridium perfringens isolates determines the ability to induce necrotic enteritis in broilers

Leen Timbermont UGent, Anouk Lanckriet UGent, Ahmadreeza Gholamiandehkordi, Frank Pasmans UGent, An Martel UGent, Freddy Haesebrouck UGent, Richard Ducatelle UGent and Filip Van Immerseel UGent (2009) COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES. 32(6). p.503-512
abstract
Since the ban on growth-promoting antibiotics in animal feed in the European Union, necrotic enteritis has become a major cause of mortality in broiler chickens. Despite the importance of the disease, the pathogenesis is still not completely understood. In the current study, Clostridium perfringens strains isolated from healthy flocks and isolates from outbreaks of necrotic enteritis were evaluated for the ability to cause gut necrosis in an intestinal loop model in laying hens and in an experimental infection model in broilers. High, intermediate and low alpha toxin producing strains were chosen from each isolation source. Only the isolates from field outbreaks induced necrotic gut lesions, independent of the amount of alpha toxin produced in vitro. It was also shown that alpha toxin producing isolates from calf hemorrhagic enteritis cases were not able to induce necrotic enteritis in poultry. These results suggest the presence of host specific virulence factors in Clostridium perfringens strains, isolated from chickens with intestinal necrotic enteritis lesions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
in vivo, Clostridium perfringens, broilers, host specificity, alpha toxin
journal title
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
Comp. Immunol. Microbiol. Infect. Dis.
volume
32
issue
6
pages
503 - 512
Web of Science type
Article
Web of Science id
000269599300004
JCR category
VETERINARY SCIENCES
JCR impact factor
2.986 (2009)
JCR rank
2/141 (2009)
JCR quartile
1 (2009)
ISSN
0147-9571
DOI
10.1016/j.cimid.2008.07.001
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
524502
handle
http://hdl.handle.net/1854/LU-524502
date created
2009-03-19 09:17:40
date last changed
2014-12-02 13:00:24
@article{524502,
  abstract     = {Since the ban on growth-promoting antibiotics in animal feed in the European Union, necrotic enteritis has become a major cause of mortality in broiler chickens. Despite the importance of the disease, the pathogenesis is still not completely understood. In the current study, Clostridium perfringens strains isolated from healthy flocks and isolates from outbreaks of necrotic enteritis were evaluated for the ability to cause gut necrosis in an intestinal loop model in laying hens and in an experimental infection model in broilers. High, intermediate and low alpha toxin producing strains were chosen from each isolation source. Only the isolates from field outbreaks induced necrotic gut lesions, independent of the amount of alpha toxin produced in vitro. It was also shown that alpha toxin producing isolates from calf hemorrhagic enteritis cases were not able to induce necrotic enteritis in poultry. These results suggest the presence of host specific virulence factors in Clostridium perfringens strains, isolated from chickens with intestinal necrotic enteritis lesions.},
  author       = {Timbermont, Leen and Lanckriet, Anouk and Gholamiandehkordi, Ahmadreeza and Pasmans, Frank and Martel, An and Haesebrouck, Freddy and Ducatelle, Richard and Van Immerseel, Filip},
  issn         = {0147-9571},
  journal      = {COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES},
  keyword      = {in vivo,Clostridium perfringens,broilers,host specificity,alpha toxin},
  language     = {eng},
  number       = {6},
  pages        = {503--512},
  title        = {Origin of Clostridium perfringens isolates determines the ability to induce necrotic enteritis in broilers},
  url          = {http://dx.doi.org/10.1016/j.cimid.2008.07.001},
  volume       = {32},
  year         = {2009},
}

Chicago
Timbermont, Leen, Anouk Lanckriet, Ahmadreeza Gholamiandehkordi, Frank Pasmans, An Martel, Freddy Haesebrouck, Richard Ducatelle, and Filip Van Immerseel. 2009. “Origin of Clostridium Perfringens Isolates Determines the Ability to Induce Necrotic Enteritis in Broilers.” Comparative Immunology Microbiology and Infectious Diseases 32 (6): 503–512.
APA
Timbermont, L., Lanckriet, A., Gholamiandehkordi, A., Pasmans, F., Martel, A., Haesebrouck, F., Ducatelle, R., et al. (2009). Origin of Clostridium perfringens isolates determines the ability to induce necrotic enteritis in broilers. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 32(6), 503–512.
Vancouver
1.
Timbermont L, Lanckriet A, Gholamiandehkordi A, Pasmans F, Martel A, Haesebrouck F, et al. Origin of Clostridium perfringens isolates determines the ability to induce necrotic enteritis in broilers. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES. 2009;32(6):503–12.
MLA
Timbermont, Leen, Anouk Lanckriet, Ahmadreeza Gholamiandehkordi, et al. “Origin of Clostridium Perfringens Isolates Determines the Ability to Induce Necrotic Enteritis in Broilers.” COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES 32.6 (2009): 503–512. Print.