Advanced search

HIV Nef: Role in pathogenesis and viral fitness

Kevin Ariën (UGent) and Bruno Verhasselt (UGent)
(2008) CURRENT HIV RESEARCH. 6(3). p.200-208
Author
Organization
Abstract
Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.
Keywords
IN-VITRO, REPLICATIVE FITNESS, TYPE-1 NEF, PROVIRAL DNA-SYNTHESIS, T-CELL-ACTIVATION, replication, HUMAN-IMMUNODEFICIENCY-VIRUS, pathogenesis, fitness, HIV, Nef, DC-SIGN, P21-ACTIVATED KINASE-2, DISEASE PROGRESSION, VIRION INFECTIVITY

Citation

Please use this url to cite or link to this publication:

Chicago
Ariën, Kevin, and Bruno Verhasselt. 2008. “HIV Nef: Role in Pathogenesis and Viral Fitness.” Current Hiv Research 6 (3): 200–208.
APA
Ariën, K., & Verhasselt, B. (2008). HIV Nef: Role in pathogenesis and viral fitness. CURRENT HIV RESEARCH, 6(3), 200–208.
Vancouver
1.
Ariën K, Verhasselt B. HIV Nef: Role in pathogenesis and viral fitness. CURRENT HIV RESEARCH. EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES: BENTHAM SCIENCE PUBL LTD,; 2008;6(3):200–8.
MLA
Ariën, Kevin, and Bruno Verhasselt. “HIV Nef: Role in Pathogenesis and Viral Fitness.” CURRENT HIV RESEARCH 6.3 (2008): 200–208. Print.
@article{521118,
  abstract     = {Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.},
  author       = {Ari{\"e}n, Kevin and Verhasselt, Bruno},
  issn         = {1570-162X},
  journal      = {CURRENT HIV RESEARCH},
  keyword      = {IN-VITRO,REPLICATIVE FITNESS,TYPE-1 NEF,PROVIRAL DNA-SYNTHESIS,T-CELL-ACTIVATION,replication,HUMAN-IMMUNODEFICIENCY-VIRUS,pathogenesis,fitness,HIV,Nef,DC-SIGN,P21-ACTIVATED KINASE-2,DISEASE PROGRESSION,VIRION INFECTIVITY},
  language     = {eng},
  number       = {3},
  pages        = {200--208},
  publisher    = {BENTHAM SCIENCE PUBL LTD,},
  title        = {HIV Nef: Role in pathogenesis and viral fitness},
  volume       = {6},
  year         = {2008},
}

Web of Science
Times cited: