Ghent University Academic Bibliography

Advanced

HIV Nef: Role in pathogenesis and viral fitness

Kevin Ariën UGent and Bruno Verhasselt UGent (2008) CURRENT HIV RESEARCH. 6(3). p.200-208
abstract
Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
IN-VITRO, REPLICATIVE FITNESS, TYPE-1 NEF, PROVIRAL DNA-SYNTHESIS, T-CELL-ACTIVATION, replication, HUMAN-IMMUNODEFICIENCY-VIRUS, pathogenesis, fitness, HIV, Nef, DC-SIGN, P21-ACTIVATED KINASE-2, DISEASE PROGRESSION, VIRION INFECTIVITY
journal title
CURRENT HIV RESEARCH
Curr. HIV Res.
volume
6
issue
3
pages
200 - 208
publisher
BENTHAM SCIENCE PUBL LTD,
place of publication
EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES
Web of Science type
Review
Web of Science id
000256616100003
JCR category
INFECTIOUS DISEASES
JCR impact factor
2.495 (2008)
JCR rank
28/51 (2008)
JCR quartile
3 (2008)
ISSN
1570-162X
language
English
UGent publication?
yes
classification
A1
id
521118
handle
http://hdl.handle.net/1854/LU-521118
date created
2009-03-18 10:49:59
date last changed
2009-03-19 08:52:45
@article{521118,
  abstract     = {Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.},
  author       = {Ari{\"e}n, Kevin and Verhasselt, Bruno},
  issn         = {1570-162X},
  journal      = {CURRENT HIV RESEARCH},
  keyword      = {IN-VITRO,REPLICATIVE FITNESS,TYPE-1 NEF,PROVIRAL DNA-SYNTHESIS,T-CELL-ACTIVATION,replication,HUMAN-IMMUNODEFICIENCY-VIRUS,pathogenesis,fitness,HIV,Nef,DC-SIGN,P21-ACTIVATED KINASE-2,DISEASE PROGRESSION,VIRION INFECTIVITY},
  language     = {eng},
  number       = {3},
  pages        = {200--208},
  publisher    = {BENTHAM SCIENCE PUBL LTD,},
  title        = {HIV Nef: Role in pathogenesis and viral fitness},
  volume       = {6},
  year         = {2008},
}

Chicago
Ariën, Kevin, and Bruno Verhasselt. 2008. “HIV Nef: Role in Pathogenesis and Viral Fitness.” Current Hiv Research 6 (3): 200–208.
APA
Ariën, K., & Verhasselt, B. (2008). HIV Nef: Role in pathogenesis and viral fitness. CURRENT HIV RESEARCH, 6(3), 200–208.
Vancouver
1.
Ariën K, Verhasselt B. HIV Nef: Role in pathogenesis and viral fitness. CURRENT HIV RESEARCH. EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES: BENTHAM SCIENCE PUBL LTD,; 2008;6(3):200–8.
MLA
Ariën, Kevin, and Bruno Verhasselt. “HIV Nef: Role in Pathogenesis and Viral Fitness.” CURRENT HIV RESEARCH 6.3 (2008): 200–208. Print.