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Integral resource management by exergy analysis for the selection of a separation process in the pharmaceutical industry.

Jo Dewulf UGent, Geert Van der Vorst UGent, W Aelterman, Bruno De Witte, H Vanbaelen and Herman Van Langenhove UGent (2007) GREEN CHEMISTRY. 9(7). p.785-791
abstract
This paper reports a detailed analysis of the resource intake necessary for the separation of a mixture of diastereoisomers (2R, 3R)-3-(3-methoxyphenyl)-N, N-2-trimethylpentanamine 6 and ( 2R, 3S)-3-(3-methoxyphenyl)-N, N-2-trimethylpentanamine 7 in the production of an active pharmaceutical ingredient. The resource intake analysis is based on exergy calculations of both material ( chemicals) and energy ( utilities) requirements. For two separation processes, crystallisation and preparative chromatography, analysis is not only carried out at the process level (alpha level), but also at the plant level (beta level) taking into account the 6 preceeding synthesis steps towards the diastereoisomers and the supporting processes, e. g. for delivering heating media from natural gas or treating waste gases. Finally, exergetic life cycle analysis allowed the inclusion of the overall industrial metabolism (gamma level) that is required to deliver all energy and materials to the plant to carry out the separation. The results show that, in this example, the large scale chromatography process is not the most resource efficient option because of its high utilities requirement, despite its lower chemical requirement ( 180 MJ versus 122 MJ total requirement per mol of the RR stereoisomer (2R, 3R)-3(3-methoxyphenyl)-N, N-2-trimethylpentanamine monohydrochloride 8) (alpha level). Due to its higher efficiency, the plant only requires 4.6% more resources when it selects chromatography instead of crystallisation ( 434 versus 415 MJ total requirement per mol of the RR stereoisomer 8) (beta level). Since the efficiencies of the overall industry depend on the type of materials and energy that it has to deliver to the plant, overall resource withdrawal from the environment differs by 4.2% for crystallisation and chromatography (883.7 and 920.6 MJ mol(-1) stereoisomer 8). The study has also shown that resource efficiency gain can be achieved by recycling solvents on the plant. Moreover, it is clear that there is more potential for resource efficiency improvement for the crystallisation than for chromatography because of the different nature of the resources consumed: chemicals, including solvents, versus utilities.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
GREEN CHEMISTRY
Green Chem.
volume
9
issue
7
pages
785 - 791
Web of Science type
Article
Web of Science id
000247709300021
JCR category
CHEMISTRY, MULTIDISCIPLINARY
JCR impact factor
4.836 (2007)
JCR rank
13/124 (2007)
JCR quartile
1 (2007)
ISSN
1463-9262
DOI
10.1039/b617505h
language
English
UGent publication?
yes
classification
A1
id
519830
handle
http://hdl.handle.net/1854/LU-519830
date created
2009-03-17 10:17:37
date last changed
2009-04-15 14:04:46
@article{519830,
  abstract     = {This paper reports a detailed analysis of the resource intake necessary for the separation of a mixture of diastereoisomers (2R, 3R)-3-(3-methoxyphenyl)-N, N-2-trimethylpentanamine 6 and ( 2R, 3S)-3-(3-methoxyphenyl)-N, N-2-trimethylpentanamine 7 in the production of an active pharmaceutical ingredient. The resource intake analysis is based on exergy calculations of both material ( chemicals) and energy ( utilities) requirements. For two separation processes, crystallisation and preparative chromatography, analysis is not only carried out at the process level (alpha level), but also at the plant level (beta level) taking into account the 6 preceeding synthesis steps towards the diastereoisomers and the supporting processes, e. g. for delivering heating media from natural gas or treating waste gases. Finally, exergetic life cycle analysis allowed the inclusion of the overall industrial metabolism (gamma level) that is required to deliver all energy and materials to the plant to carry out the separation. The results show that, in this example, the large scale chromatography process is not the most resource efficient option because of its high utilities requirement, despite its lower chemical requirement ( 180 MJ versus 122 MJ total requirement per mol of the RR stereoisomer (2R, 3R)-3(3-methoxyphenyl)-N, N-2-trimethylpentanamine monohydrochloride 8) (alpha level). Due to its higher efficiency, the plant only requires 4.6\% more resources when it selects chromatography instead of crystallisation ( 434 versus 415 MJ total requirement per mol of the RR stereoisomer 8) (beta level). Since the efficiencies of the overall industry depend on the type of materials and energy that it has to deliver to the plant, overall resource withdrawal from the environment differs by 4.2\% for crystallisation and chromatography (883.7 and 920.6 MJ mol(-1) stereoisomer 8). The study has also shown that resource efficiency gain can be achieved by recycling solvents on the plant. Moreover, it is clear that there is more potential for resource efficiency improvement for the crystallisation than for chromatography because of the different nature of the resources consumed: chemicals, including solvents, versus utilities.},
  author       = {Dewulf, Jo and Van der Vorst, Geert and Aelterman, W and De Witte, Bruno and Vanbaelen, H and Van Langenhove, Herman},
  issn         = {1463-9262},
  journal      = {GREEN CHEMISTRY},
  language     = {eng},
  number       = {7},
  pages        = {785--791},
  title        = {Integral resource management by exergy analysis for the selection of a separation process in the pharmaceutical industry.},
  url          = {http://dx.doi.org/10.1039/b617505h},
  volume       = {9},
  year         = {2007},
}

Chicago
Dewulf, Jo, Geert Van der Vorst, W Aelterman, Bruno De Witte, H Vanbaelen, and Herman Van Langenhove. 2007. “Integral Resource Management by Exergy Analysis for the Selection of a Separation Process in the Pharmaceutical Industry.” Green Chemistry 9 (7): 785–791.
APA
Dewulf, Jo, Van der Vorst, G., Aelterman, W., De Witte, B., Vanbaelen, H., & Van Langenhove, H. (2007). Integral resource management by exergy analysis for the selection of a separation process in the pharmaceutical industry. GREEN CHEMISTRY, 9(7), 785–791.
Vancouver
1.
Dewulf J, Van der Vorst G, Aelterman W, De Witte B, Vanbaelen H, Van Langenhove H. Integral resource management by exergy analysis for the selection of a separation process in the pharmaceutical industry. GREEN CHEMISTRY. 2007;9(7):785–91.
MLA
Dewulf, Jo, Geert Van der Vorst, W Aelterman, et al. “Integral Resource Management by Exergy Analysis for the Selection of a Separation Process in the Pharmaceutical Industry.” GREEN CHEMISTRY 9.7 (2007): 785–791. Print.