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Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: A proton magnetic resonance spectroscopy study

(1997) NEUROLOGY. 49(2). p.438-444
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Organization
Abstract
We have carried out single-voxel proton magnetic resonance spectroscopy centered on the putamen both ipsilateral and contralateral to the worst affected side in nine subjects with drug naive idiopathic Parkinson's disease (IPD); seven chronically levodopa-treated dyskinetic IPD subjects; and 11 age-matched healthy controls. Measurements of N-acetylaspartate (NAA)/choline (Cho), NAA/(Creatine + Phosphocreatine) (Cr+PCr), and Cho/(Cr+PCr) were made. We found a significant reduction in NAA/Cho ratios from the putamen contralateral to the most affected side in the drug-naive group (p = 0.009), but not the levodopa-treated IPD groups compared with controls, There were no significant differences in NAA/(Cr+PCr) or Cho/(Cr+PCr) ratios. In untreated IPD, reduced putaminal NAA/Cho ratios may reflect loss of nigrostriatal dopamine terminals or alternatively indicate a functional abnormality of striatal putaminal neurons, such as membrane dysfunction due to striatal deafferentation. This study suggests that NAA/Cho ratios may be affected by L-dopa therapy and this may provide a reversible marker of neuronal dysfunction in the striatum.

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Chicago
Ellis, C.M., Gilbert Lemmens, S.C.R. Williams, A. Simmons, J. Dawson, P.N. Leigh, and K.R. Chaudhuri. 1997. “Changes in Putamen N-acetylaspartate and Choline Ratios in Untreated and Levodopa-treated Parkinson’s Disease: A Proton Magnetic Resonance Spectroscopy Study.” Neurology 49 (2): 438–444.
APA
Ellis, C. M., Lemmens, G., Williams, S. C. R., Simmons, A., Dawson, J., Leigh, P. N., & Chaudhuri, K. R. (1997). Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson’s disease: A proton magnetic resonance spectroscopy study. NEUROLOGY, 49(2), 438–444.
Vancouver
1.
Ellis CM, Lemmens G, Williams SCR, Simmons A, Dawson J, Leigh PN, et al. Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson’s disease: A proton magnetic resonance spectroscopy study. NEUROLOGY. 1997;49(2):438–44.
MLA
Ellis, C.M., Gilbert Lemmens, S.C.R. Williams, et al. “Changes in Putamen N-acetylaspartate and Choline Ratios in Untreated and Levodopa-treated Parkinson’s Disease: A Proton Magnetic Resonance Spectroscopy Study.” NEUROLOGY 49.2 (1997): 438–444. Print.
@article{519468,
  abstract     = {We have carried out single-voxel proton magnetic resonance spectroscopy centered on the putamen both ipsilateral and contralateral to the worst affected side in nine subjects with drug naive idiopathic Parkinson's disease (IPD); seven chronically levodopa-treated dyskinetic IPD subjects; and 11 age-matched healthy controls. Measurements of N-acetylaspartate (NAA)/choline (Cho), NAA/(Creatine + Phosphocreatine) (Cr+PCr), and Cho/(Cr+PCr) were made. We found a significant reduction in NAA/Cho ratios from the putamen contralateral to the most affected side in the drug-naive group (p = 0.009), but not the levodopa-treated IPD groups compared with controls, There were no significant differences in NAA/(Cr+PCr) or Cho/(Cr+PCr) ratios. In untreated IPD, reduced putaminal NAA/Cho ratios may reflect loss of nigrostriatal dopamine terminals or alternatively indicate a functional abnormality of striatal putaminal neurons, such as membrane dysfunction due to striatal deafferentation. This study suggests that NAA/Cho ratios may be affected by L-dopa therapy and this may provide a reversible marker of neuronal dysfunction in the striatum.},
  author       = {Ellis, C.M. and Lemmens, Gilbert and Williams, S.C.R. and Simmons, A. and Dawson, J. and Leigh, P.N. and Chaudhuri, K.R.},
  issn         = {0028-3878},
  journal      = {NEUROLOGY},
  language     = {eng},
  number       = {2},
  pages        = {438--444},
  title        = {Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: A proton magnetic resonance spectroscopy study},
  volume       = {49},
  year         = {1997},
}