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Evolution of bacterial susceptibility pattern of Escherichia coli in uncomplicated urinary tract infections in a country with high antibiotic consumption: a comparison of two surveys with a 10 year interval

David De Backer UGent, Thierry Christiaens UGent, Stefan Heytens UGent, An De Sutter UGent, Ellen Stobberingh and GERDA VERSCHRAEGEN UGent (2008) JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 62(2). p.364-368
abstract
Objectives: For the empirical treatment of cystitis, clinicians are often guided by susceptibility data taken from urinary samples that sent to regional microbiological laboratories, which are not representatives for uncomplicated urinary tract infections (UTIs). To offer adequate recommendations, the distribution and susceptibility pattern of uropathogens in uncomplicated UTIs in women were compared with those obtained 10 years ago in our uropathogen surveillance in a primary healthcare setting. Methods: Sixty-six general practitioners in the region of the city of Ghent were asked to inoculate a dipslide with midstream urine from every adult female patient with complaints suggestive for cystitis, during a period of 1 year. The dipslides were further processed in a central microbiological laboratory, where counting, identification and susceptibility testing were performed. Results: Three hundred specimens were collected, of which 187 (62.3%) yielded a positive culture of 10(5) cfu/mL. In the age group of 18-54 years, Escherichia coli was the most frequently isolated uropathogen (77.5%), followed by Staphylococcus saprophyticus (13.5%) and Proteus spp. (2.7%). There were no statistically significant differences when compared with the data from 1996. In 2006, susceptibility of E. coli to nitrofurantoin was 100%, to quinolones 100%, to ampicillin 62.8% and to co-trimoxazole 86%, compared with 99.3%, 99.3%, 73.2% and 83.3%, respectively, in 1996 (no statistically significant differences). Conclusions: Over a period of 10 years, a systematic surveillance of uropathogens in female patients with uncomplicated UTI in general practice could not demonstrate a significant change in species distribution or antimicrobial susceptibility.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CYSTITIS, ESAC, RESISTANCE, COMMUNITY, WOMEN, cystitis, EUROPEAN SURVEILLANCE, resistance, uropathogens
journal title
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
J. Antimicrob. Chemother.
volume
62
issue
2
pages
364 - 368
Web of Science type
Article
Web of Science id
000257578200021
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
4.328 (2008)
JCR rank
33/216 (2008)
JCR quartile
1 (2008)
ISSN
0305-7453
DOI
10.1093/jac/dkn197
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
519141
handle
http://hdl.handle.net/1854/LU-519141
date created
2009-03-16 14:20:26
date last changed
2011-06-08 08:38:58
@article{519141,
  abstract     = {Objectives: For the empirical treatment of cystitis, clinicians are often guided by susceptibility data taken from urinary samples that sent to regional microbiological laboratories, which are not representatives for uncomplicated urinary tract infections (UTIs). To offer adequate recommendations, the distribution and susceptibility pattern of uropathogens in uncomplicated UTIs in women were compared with those obtained 10 years ago in our uropathogen surveillance in a primary healthcare setting.
Methods: Sixty-six general practitioners in the region of the city of Ghent were asked to inoculate a dipslide with midstream urine from every adult female patient with complaints suggestive for cystitis, during a period of 1 year. The dipslides were further processed in a central microbiological laboratory, where counting, identification and susceptibility testing were performed.
Results: Three hundred specimens were collected, of which 187 (62.3\%) yielded a positive culture of 10(5) cfu/mL. In the age group of 18-54 years, Escherichia coli was the most frequently isolated uropathogen (77.5\%), followed by Staphylococcus saprophyticus (13.5\%) and Proteus spp. (2.7\%). There were no statistically significant differences when compared with the data from 1996. In 2006, susceptibility of E. coli to nitrofurantoin was 100\%, to quinolones 100\%, to ampicillin 62.8\% and to co-trimoxazole 86\%, compared with 99.3\%, 99.3\%, 73.2\% and 83.3\%, respectively, in 1996 (no statistically significant differences).
Conclusions: Over a period of 10 years, a systematic surveillance of uropathogens in female patients with uncomplicated UTI in general practice could not demonstrate a significant change in species distribution or antimicrobial susceptibility.},
  author       = {De Backer, David and Christiaens, Thierry and Heytens, Stefan and De Sutter, An and Stobberingh, Ellen and VERSCHRAEGEN, GERDA},
  issn         = {0305-7453},
  journal      = {JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY},
  keyword      = {CYSTITIS,ESAC,RESISTANCE,COMMUNITY,WOMEN,cystitis,EUROPEAN SURVEILLANCE,resistance,uropathogens},
  language     = {eng},
  number       = {2},
  pages        = {364--368},
  title        = {Evolution of bacterial susceptibility pattern of Escherichia coli in uncomplicated urinary tract infections in a country with high antibiotic consumption: a comparison of two surveys with a 10 year interval},
  url          = {http://dx.doi.org/10.1093/jac/dkn197},
  volume       = {62},
  year         = {2008},
}

Chicago
De Backer, David, Thierry Christiaens, Stefan Heytens, An De Sutter, Ellen Stobberingh, and GERDA VERSCHRAEGEN. 2008. “Evolution of Bacterial Susceptibility Pattern of Escherichia Coli in Uncomplicated Urinary Tract Infections in a Country with High Antibiotic Consumption: a Comparison of Two Surveys with a 10 Year Interval.” Journal of Antimicrobial Chemotherapy 62 (2): 364–368.
APA
De Backer, D., Christiaens, T., Heytens, S., De Sutter, A., Stobberingh, E., & VERSCHRAEGEN, G. (2008). Evolution of bacterial susceptibility pattern of Escherichia coli in uncomplicated urinary tract infections in a country with high antibiotic consumption: a comparison of two surveys with a 10 year interval. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 62(2), 364–368.
Vancouver
1.
De Backer D, Christiaens T, Heytens S, De Sutter A, Stobberingh E, VERSCHRAEGEN G. Evolution of bacterial susceptibility pattern of Escherichia coli in uncomplicated urinary tract infections in a country with high antibiotic consumption: a comparison of two surveys with a 10 year interval. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2008;62(2):364–8.
MLA
De Backer, David, Thierry Christiaens, Stefan Heytens, et al. “Evolution of Bacterial Susceptibility Pattern of Escherichia Coli in Uncomplicated Urinary Tract Infections in a Country with High Antibiotic Consumption: a Comparison of Two Surveys with a 10 Year Interval.” JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 62.2 (2008): 364–368. Print.