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Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains

Kristen Chalmet (UGent) , Filip Van Wanzeele (UGent) , Els Demecheleer (UGent) , Kenny Dauwe (UGent) , Jolanda Pelgrom (UGent) , Beatrijs Van Der Gucht (UGent) , Dirk Vogelaers (UGent) , Jean Plum (UGent) , Lieven Stuyver, Linos Vandekerckhove (UGent) , et al.
(2008) Virology. 379(2). p.213-222
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Abstract
A cluster of four patients acutely infected with a genetically almost identical virus, allowed us to investigate genetic variability and disease progression in early HIV-1 infection with minimal interference of Virus specific factors. Two of the patients were heterozygous for the 32-bp deletion in the CCR5 coreceptor gene. Both showed a slower disease progression with lower viral load levels and a reduced rate of genetic evolution compared to the patients with normal CCR5 alleles. During 3 years of treatment-free follow-up, the mean pairwise genetic distance increased with 1.45% and 1.58% in the two patients with a 32-bp deletion allele Compared to 3.05% and 3.57% in the two patients with normal CCR5 alleles. The observed relation between slower disease progression and a reduced evolutionary rate illustrates the influence of the virus replicative capacity, here most possibly hampered by the CCR5 heterozygosity in two of the four individuals, on the genetic evolution of the virus in the host. (C) 2008 Elsevier Inc. All rights reserved.
Keywords
HIV-1 evolution, Delta 32-CCR5 heterozygosity

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Chicago
Chalmet, Kristen, Filip Van Wanzeele, Els Demecheleer, Kenny Dauwe, Jolanda Pelgrom, Beatrijs Van Der Gucht, Dirk Vogelaers, et al. 2008. “Impact of Delta 32-CCR5 Heterozygosity on HIV-1 Genetic Evolution and Variability - A Study of 4 Individuals Infected with Closely Related HIV-1 Strains.” Virology 379 (2): 213–222.
APA
Chalmet, K., Van Wanzeele, F., Demecheleer, E., Dauwe, K., Pelgrom, J., Van Der Gucht, B., Vogelaers, D., et al. (2008). Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains. Virology, 379(2), 213–222.
Vancouver
1.
Chalmet K, Van Wanzeele F, Demecheleer E, Dauwe K, Pelgrom J, Van Der Gucht B, et al. Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains. Virology. 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA: ACADEMIC PRESS INC ELSEVIER SCIENCE; 2008;379(2):213–22.
MLA
Chalmet, Kristen, Filip Van Wanzeele, Els Demecheleer, et al. “Impact of Delta 32-CCR5 Heterozygosity on HIV-1 Genetic Evolution and Variability - A Study of 4 Individuals Infected with Closely Related HIV-1 Strains.” Virology 379.2 (2008): 213–222. Print.
@article{519053,
  abstract     = {A cluster of four patients acutely infected with a genetically almost identical virus, allowed us to investigate genetic variability and disease progression in early HIV-1 infection with minimal interference of Virus specific factors. Two of the patients were heterozygous for the 32-bp deletion in the CCR5 coreceptor gene. Both showed a slower disease progression with lower viral load levels and a reduced rate of genetic evolution compared to the patients with normal CCR5 alleles. During 3 years of treatment-free follow-up, the mean pairwise genetic distance increased with 1.45\% and 1.58\% in the two patients with a 32-bp deletion allele Compared to 3.05\% and 3.57\% in the two patients with normal CCR5 alleles. The observed relation between slower disease progression and a reduced evolutionary rate illustrates the influence of the virus replicative capacity, here most possibly hampered by the CCR5 heterozygosity in two of the four individuals, on the genetic evolution of the virus in the host. (C) 2008 Elsevier Inc. All rights reserved.},
  author       = {Chalmet, Kristen and Van Wanzeele, Filip and Demecheleer, Els and Dauwe, Kenny and Pelgrom, Jolanda and Van Der Gucht, Beatrijs and Vogelaers, Dirk and Plum, Jean and Stuyver, Lieven and Vandekerckhove, Linos and Verhofstede, Chris},
  issn         = {0042-6822},
  journal      = {Virology},
  keyword      = {HIV-1 evolution,Delta 32-CCR5 heterozygosity},
  language     = {eng},
  number       = {2},
  pages        = {213--222},
  publisher    = {ACADEMIC PRESS INC ELSEVIER SCIENCE},
  title        = {Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains},
  url          = {http://dx.doi.org/10.1016/j.virol.2008.06.036},
  volume       = {379},
  year         = {2008},
}

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