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Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains

Kristen Chalmet UGent, Filip Van Wanzeele, Els Demecheleer UGent, Kenny Dauwe UGent, Jolanda Pelgrom, Beatrijs Van Der Gucht, Dirk Vogelaers UGent, Jean Plum, Lieven Stuyver, Linos Vandekerckhove UGent, et al. (2008) Virology. 379(2). p.213-222
abstract
A cluster of four patients acutely infected with a genetically almost identical virus, allowed us to investigate genetic variability and disease progression in early HIV-1 infection with minimal interference of Virus specific factors. Two of the patients were heterozygous for the 32-bp deletion in the CCR5 coreceptor gene. Both showed a slower disease progression with lower viral load levels and a reduced rate of genetic evolution compared to the patients with normal CCR5 alleles. During 3 years of treatment-free follow-up, the mean pairwise genetic distance increased with 1.45% and 1.58% in the two patients with a 32-bp deletion allele Compared to 3.05% and 3.57% in the two patients with normal CCR5 alleles. The observed relation between slower disease progression and a reduced evolutionary rate illustrates the influence of the virus replicative capacity, here most possibly hampered by the CCR5 heterozygosity in two of the four individuals, on the genetic evolution of the virus in the host. (C) 2008 Elsevier Inc. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HIV-1 evolution, Delta 32-CCR5 heterozygosity
journal title
Virology
volume
379
issue
2
pages
213 - 222
publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
place of publication
525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
Web of Science type
Article
Web of Science id
000259549500006
JCR category
VIROLOGY
JCR impact factor
3.539 (2008)
JCR rank
8/27 (2008)
JCR quartile
2 (2008)
ISSN
0042-6822
DOI
10.1016/j.virol.2008.06.036
language
English
UGent publication?
yes
classification
A1
id
519053
handle
http://hdl.handle.net/1854/LU-519053
date created
2009-03-16 14:08:38
date last changed
2017-01-02 09:54:26
@article{519053,
  abstract     = {A cluster of four patients acutely infected with a genetically almost identical virus, allowed us to investigate genetic variability and disease progression in early HIV-1 infection with minimal interference of Virus specific factors. Two of the patients were heterozygous for the 32-bp deletion in the CCR5 coreceptor gene. Both showed a slower disease progression with lower viral load levels and a reduced rate of genetic evolution compared to the patients with normal CCR5 alleles. During 3 years of treatment-free follow-up, the mean pairwise genetic distance increased with 1.45\% and 1.58\% in the two patients with a 32-bp deletion allele Compared to 3.05\% and 3.57\% in the two patients with normal CCR5 alleles. The observed relation between slower disease progression and a reduced evolutionary rate illustrates the influence of the virus replicative capacity, here most possibly hampered by the CCR5 heterozygosity in two of the four individuals, on the genetic evolution of the virus in the host. (C) 2008 Elsevier Inc. All rights reserved.},
  author       = {Chalmet, Kristen and Van Wanzeele, Filip and Demecheleer, Els and Dauwe, Kenny and Pelgrom, Jolanda and Van Der Gucht, Beatrijs and Vogelaers, Dirk and Plum, Jean and Stuyver, Lieven and Vandekerckhove, Linos and Verhofstede, Chris},
  issn         = {0042-6822},
  journal      = {Virology},
  keyword      = {HIV-1 evolution,Delta 32-CCR5 heterozygosity},
  language     = {eng},
  number       = {2},
  pages        = {213--222},
  publisher    = {ACADEMIC PRESS INC ELSEVIER SCIENCE},
  title        = {Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains},
  url          = {http://dx.doi.org/10.1016/j.virol.2008.06.036},
  volume       = {379},
  year         = {2008},
}

Chicago
Chalmet, Kristen, FILIP VAN WANZEELE, Els Demecheleer, Kenny Dauwe, JOLANDA PELGROM, BEATRIJS VAN DER GUCHT, Dirk Vogelaers, et al. 2008. “Impact of Delta 32-CCR5 Heterozygosity on HIV-1 Genetic Evolution and Variability - A Study of 4 Individuals Infected with Closely Related HIV-1 Strains.” Virology 379 (2): 213–222.
APA
Chalmet, K., VAN WANZEELE, F., Demecheleer, E., Dauwe, K., PELGROM, J., VAN DER GUCHT, B., Vogelaers, D., et al. (2008). Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains. Virology, 379(2), 213–222.
Vancouver
1.
Chalmet K, VAN WANZEELE F, Demecheleer E, Dauwe K, PELGROM J, VAN DER GUCHT B, et al. Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability - A study of 4 individuals infected with closely related HIV-1 strains. Virology. 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA: ACADEMIC PRESS INC ELSEVIER SCIENCE; 2008;379(2):213–22.
MLA
Chalmet, Kristen, FILIP VAN WANZEELE, Els Demecheleer, et al. “Impact of Delta 32-CCR5 Heterozygosity on HIV-1 Genetic Evolution and Variability - A Study of 4 Individuals Infected with Closely Related HIV-1 Strains.” Virology 379.2 (2008): 213–222. Print.