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Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats

Adronie Verbrugghe UGent, Myriam Hesta UGent, Kris Gommeren, Sylvie Daminet UGent, Birgitte Wuyts, Johan Buyse and Geert Janssens UGent (2009) BRITISH JOURNAL OF NUTRITION. 102(5). p.694-702
abstract
The effect of dietary oligofructose and inulin supplementation on glucose metabolism in obese and non-obese cats was assessed. Two diets were tested in a crossover design; a control diet high in protein (46% on DM basis), moderate in fat (15 %), low in carbohydrates (27 %), but no soluble fibres added; and a prebiotic diet, with 2·5% of a mixture of oligofructose and inulin added to the control diet. Eight non-obese and eight obese cats were allotted to each of two diets in random order at intervals of 4 weeks. At the end of each testing period, intravenous glucose tolerance tests were performed. Area under the glucose curve (AUCgluc) was increased (P=0·022) and the second insulin peak was delayed (P=0·009) in obese compared to non-obese cats. Diets did not affect fasting plasma glucose concentrations, blood glucose response at each glucose time-point after glucose administration, AUCgluc, fasting serum insulin concentrations, area under the insulin curve, and height and appearance time of insulin response. Yet, analysis of acylcarnitines revealed higher propionylcarnitine concentrations (P=0·03) when fed the prebiotic diet, suggesting colonic fermentation and propionate absorption. Prebiotic supplementation reduced methylmalonylcarnitine (P=0·072) and aspartate aminotransferase concentrations (P=0·025), both indicating reduced gluconeogenesis from amino acids. This trial evidenced impaired glucose tolerance and altered insulin response to glucose administration in obese compared to non-obese cats, regardless of dietary intervention; yet modulation of glucose metabolism by enhancing gluconeogenesis from propionate and inhibition of amino acid catabolism can be suggested.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
dietary fibre, Carbohydrate metabolism, SHORT-CHAIN FRUCTOOLIGOSACCHARIDES, SUGAR-BEET FIBER, obesity, cats, INSULIN SENSITIVITY, DIABETES-MELLITUS, FRUCTO-OLIGOSACCHARIDES, NUTRIENT DIGESTIBILITY, DIETARY FIBER, FATTY-ACIDS, ALANINE AMINOTRANSFERASE, CHRONIC CONSUMPTION
journal title
BRITISH JOURNAL OF NUTRITION
Br. J. Nutr.
volume
102
issue
5
pages
694 - 702
Web of Science type
Article
Web of Science id
000270205300007
JCR category
NUTRITION & DIETETICS
JCR impact factor
3.446 (2009)
JCR rank
11/66 (2009)
JCR quartile
1 (2009)
ISSN
0007-1145
DOI
10.1017/S0007114509288982
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
518406
handle
http://hdl.handle.net/1854/LU-518406
date created
2009-03-16 09:46:18
date last changed
2012-10-26 12:01:29
@article{518406,
  abstract     = {The effect of dietary oligofructose and inulin supplementation on glucose metabolism in obese and non-obese cats was assessed. Two diets were tested in a crossover design; a control diet high in protein (46\% on DM basis), moderate in fat (15 \%), low in carbohydrates (27 \%), but no soluble fibres added; and a prebiotic diet, with 2{\textperiodcentered}5\% of a mixture of oligofructose and inulin added to the control diet. Eight non-obese and eight obese cats were allotted to each of two diets in random order at intervals of 4 weeks. At the end of each testing period, intravenous glucose tolerance tests were performed. Area under the glucose curve (AUCgluc) was increased (P=0{\textperiodcentered}022) and the second insulin peak was delayed (P=0{\textperiodcentered}009) in obese compared to non-obese cats. Diets did not affect fasting plasma glucose concentrations, blood glucose response at each glucose time-point after glucose administration, AUCgluc, fasting serum insulin concentrations, area under the insulin curve, and height and appearance time of insulin response. Yet, analysis of acylcarnitines revealed higher propionylcarnitine concentrations (P=0{\textperiodcentered}03) when fed the prebiotic diet, suggesting colonic fermentation and propionate absorption. Prebiotic supplementation reduced methylmalonylcarnitine (P=0{\textperiodcentered}072) and aspartate aminotransferase concentrations (P=0{\textperiodcentered}025), both indicating reduced gluconeogenesis from amino acids. This trial evidenced impaired glucose tolerance and altered insulin response to glucose administration in obese compared to non-obese cats, regardless of dietary intervention; yet modulation of glucose metabolism by enhancing gluconeogenesis from propionate and inhibition of amino acid catabolism can be suggested.},
  author       = {Verbrugghe, Adronie and Hesta, Myriam and Gommeren, Kris and Daminet, Sylvie and Wuyts, Birgitte and Buyse, Johan and Janssens, Geert},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  keyword      = {dietary fibre,Carbohydrate metabolism,SHORT-CHAIN FRUCTOOLIGOSACCHARIDES,SUGAR-BEET FIBER,obesity,cats,INSULIN SENSITIVITY,DIABETES-MELLITUS,FRUCTO-OLIGOSACCHARIDES,NUTRIENT DIGESTIBILITY,DIETARY FIBER,FATTY-ACIDS,ALANINE AMINOTRANSFERASE,CHRONIC CONSUMPTION},
  language     = {eng},
  number       = {5},
  pages        = {694--702},
  title        = {Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats},
  url          = {http://dx.doi.org/10.1017/S0007114509288982},
  volume       = {102},
  year         = {2009},
}

Chicago
Verbrugghe, Adronie, Myriam Hesta, Kris Gommeren, Sylvie Daminet, Birgitte Wuyts, Johan Buyse, and Geert Janssens. 2009. “Oligofructose and Inulin Modulate Glucose and Amino Acid Metabolism Through Propionate Production in Normal-weight and Obese Cats.” British Journal of Nutrition 102 (5): 694–702.
APA
Verbrugghe, A., Hesta, M., Gommeren, K., Daminet, S., Wuyts, B., Buyse, J., & Janssens, G. (2009). Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats. BRITISH JOURNAL OF NUTRITION, 102(5), 694–702.
Vancouver
1.
Verbrugghe A, Hesta M, Gommeren K, Daminet S, Wuyts B, Buyse J, et al. Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats. BRITISH JOURNAL OF NUTRITION. 2009;102(5):694–702.
MLA
Verbrugghe, Adronie, Myriam Hesta, Kris Gommeren, et al. “Oligofructose and Inulin Modulate Glucose and Amino Acid Metabolism Through Propionate Production in Normal-weight and Obese Cats.” BRITISH JOURNAL OF NUTRITION 102.5 (2009): 694–702. Print.