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Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography–mass spectrometry

Sarah MR Wille, Els De Letter UGent, Michel Piette UGent, Lien K Van Overschelde, Carlos Van Peteghem UGent and Willy Lambert UGent (2009) INTERNATIONAL JOURNAL OF LEGAL MEDICINE. 123(6). p.451-458
abstract
A gas chromatographic-mass spectrometric (GC-MS) method in positive ion chemical ionization mode in combination with a solid phase extraction was optimized for new-generation antidepressants and their metabolites in postmortem blood, brain tissue, and hair. Twelve antidepressants and their active metabolites (i.e., mirtazapine, viloxazine, venlafaxine, citalopram, mianserin, reboxetine, fluoxetine, fluvoxamine, sertraline, maprotiline, melitracen, paroxetine, desmethylfluoxetine, desmethylmianserin, desmethylmirtazapine, desmethylsertraline, desmethylmaprotiline, desmethylcitalopram, and didesmethylcitalopram) could be quantified. In this article, in addition to the validation of the GC-MS method, four postmortem cases are discussed to demonstrate the usefulness of the described method in forensic toxicology. In these cases, sertraline, fluoxetine, citalopram, and trazodone in combination with their active metabolites were quantified. Blood concentrations ranged from subtherapeutic to toxic concentrations, while brain to plasma ratios ranged from 0.8 to 17. Hair concentrations ranged from 0.4 to 2.5 ng/mg depending on the compound and hair segment.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Selective serotonin reuptake inhibitors (SSRI) and metabolites, Hair analysis, GC-MS, Postmortem toxicology, Brain analysis, NEW-GENERATION ANTIDEPRESSANTS, HUMAN SCALP HAIR, ACTIVE METABOLITES, DRUGS, INTOXICATION, MOCLOBEMIDE, IONIZATION, FLUOXETINE, CITALOPRAM, TRAZODONE
journal title
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
Int. J. Legal Med.
volume
123
issue
6
pages
451 - 458
Web of Science type
Article
Web of Science id
000271071100001
JCR category
MEDICINE, LEGAL
JCR impact factor
2.793 (2009)
JCR rank
1/11 (2009)
JCR quartile
1 (2009)
ISSN
0937-9827
1437-1596
DOI
10.1007/s00414-008-0287-6
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
517620
handle
http://hdl.handle.net/1854/LU-517620
date created
2009-03-12 13:16:52
date last changed
2015-06-17 11:08:28
@article{517620,
  abstract     = {A gas chromatographic-mass spectrometric (GC-MS) method in positive ion chemical ionization mode in combination with a solid phase extraction was optimized for new-generation antidepressants and their metabolites in postmortem blood, brain tissue, and hair. Twelve antidepressants and their active metabolites (i.e., mirtazapine, viloxazine, venlafaxine, citalopram, mianserin, reboxetine, fluoxetine, fluvoxamine, sertraline, maprotiline, melitracen, paroxetine, desmethylfluoxetine, desmethylmianserin, desmethylmirtazapine, desmethylsertraline, desmethylmaprotiline, desmethylcitalopram, and didesmethylcitalopram) could be quantified. In this article, in addition to the validation of the GC-MS method, four postmortem cases are discussed to demonstrate the usefulness of the described method in forensic toxicology. In these cases, sertraline, fluoxetine, citalopram, and trazodone in combination with their active metabolites were quantified. Blood concentrations ranged from subtherapeutic to toxic concentrations, while brain to plasma ratios ranged from 0.8 to 17. Hair concentrations ranged from 0.4 to 2.5 ng/mg depending on the compound and hair segment.},
  author       = {Wille, Sarah MR and De Letter, Els and Piette, Michel and Van Overschelde, Lien K and Van Peteghem, Carlos and Lambert, Willy},
  issn         = {0937-9827},
  journal      = {INTERNATIONAL JOURNAL OF LEGAL MEDICINE},
  keyword      = {Selective serotonin reuptake inhibitors (SSRI) and metabolites,Hair analysis,GC-MS,Postmortem toxicology,Brain analysis,NEW-GENERATION ANTIDEPRESSANTS,HUMAN SCALP HAIR,ACTIVE METABOLITES,DRUGS,INTOXICATION,MOCLOBEMIDE,IONIZATION,FLUOXETINE,CITALOPRAM,TRAZODONE},
  language     = {eng},
  number       = {6},
  pages        = {451--458},
  title        = {Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography--mass spectrometry},
  url          = {http://dx.doi.org/10.1007/s00414-008-0287-6},
  volume       = {123},
  year         = {2009},
}

Chicago
Wille, Sarah MR, Els De Letter, Michel Piette, Lien K Van Overschelde, Carlos Van Peteghem, and Willy Lambert. 2009. “Determination of Antidepressants in Human Postmortem Blood, Brain Tissue, and Hair Using Gas Chromatography–mass Spectrometry.” International Journal of Legal Medicine 123 (6): 451–458.
APA
Wille, S. M., De Letter, E., Piette, M., Van Overschelde, L. K., Van Peteghem, C., & Lambert, W. (2009). Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography–mass spectrometry. INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 123(6), 451–458.
Vancouver
1.
Wille SM, De Letter E, Piette M, Van Overschelde LK, Van Peteghem C, Lambert W. Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography–mass spectrometry. INTERNATIONAL JOURNAL OF LEGAL MEDICINE. 2009;123(6):451–8.
MLA
Wille, Sarah MR, Els De Letter, Michel Piette, et al. “Determination of Antidepressants in Human Postmortem Blood, Brain Tissue, and Hair Using Gas Chromatography–mass Spectrometry.” INTERNATIONAL JOURNAL OF LEGAL MEDICINE 123.6 (2009): 451–458. Print.