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Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model

(2008) EUROPEAN SURGICAL RESEARCH. 41(4). p.346-352
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Organization
Abstract
Background: Abdominal wall repair can be performed with synthetic or biological materials. Biological materials may reduce the risk of infections and fibrosis. The aim of this study was to evaluate two acellular human dermis products. Materials and Methods: A rat model was used to compare the two materials. One was prepared using low concentrations of NaOH; the other material was SureDerm (TM), which is commercially available. Full thickness defects were prepared in the abdominal wall and closed with the materials. Rats were sacrificed at 1 or 4 months after operation and the numbers of adhesions to the bowels were scored. Samples were taken for histological analysis and to measure the breaking strength. Results: In both groups a good functional integration of the implants with the abdominal wall was observed. There was no adhesion formation with the bowels in the group with the NaOH prototype. In the SureDerm group, 4 out of 7 rats showed only small adhesions at 4 months after operation. Breaking strength of the healed tissue was significantly higher in the NaOH prototype group at 4 months after operation (p < 0.0026). Conclusions: The results indicate that both human acellular dermis products may be used in clinical trials for closure of abdominal wall defects.

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Please use this url to cite or link to this publication:

MLA
Pirayesh, Ali et al. “Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model.” EUROPEAN SURGICAL RESEARCH 41.4 (2008): 346–352. Print.
APA
Pirayesh, A., Dur, A., Paauw, N., Monstrey, S., Kreis, R., Hoekstra, M., & Richters, C. (2008). Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model. EUROPEAN SURGICAL RESEARCH, 41(4), 346–352.
Chicago author-date
Pirayesh, Ali, AHM Dur, NJ Paauw, Stan Monstrey, RW Kreis, MJ Hoekstra, and CD Richters. 2008. “Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model.” European Surgical Research 41 (4): 346–352.
Chicago author-date (all authors)
Pirayesh, Ali, AHM Dur, NJ Paauw, Stan Monstrey, RW Kreis, MJ Hoekstra, and CD Richters. 2008. “Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model.” European Surgical Research 41 (4): 346–352.
Vancouver
1.
Pirayesh A, Dur A, Paauw N, Monstrey S, Kreis R, Hoekstra M, et al. Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model. EUROPEAN SURGICAL RESEARCH. 2008;41(4):346–52.
IEEE
[1]
A. Pirayesh et al., “Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model,” EUROPEAN SURGICAL RESEARCH, vol. 41, no. 4, pp. 346–352, 2008.
@article{517272,
  abstract     = {Background: Abdominal wall repair can be performed with synthetic or biological materials. Biological materials may reduce the risk of infections and fibrosis. The aim of this study was to evaluate two acellular human dermis products. Materials and Methods: A rat model was used to compare the two materials. One was prepared using low concentrations of NaOH; the other material was SureDerm (TM), which is commercially available. Full thickness defects were prepared in the abdominal wall and closed with the materials. Rats were sacrificed at 1 or 4 months after operation and the numbers of adhesions to the bowels were scored. Samples were taken for histological analysis and to measure the breaking strength. Results: In both groups a good functional integration of the implants with the abdominal wall was observed. There was no adhesion formation with the bowels in the group with the NaOH prototype. In the SureDerm group, 4 out of 7 rats showed only small adhesions at 4 months after operation. Breaking strength of the healed tissue was significantly higher in the NaOH prototype group at 4 months after operation (p < 0.0026). Conclusions: The results indicate that both human acellular dermis products may be used in clinical trials for closure of abdominal wall defects.},
  author       = {Pirayesh, Ali and Dur, AHM and Paauw, NJ and Monstrey, Stan and Kreis, RW and Hoekstra, MJ and Richters, CD},
  issn         = {0014-312X},
  journal      = {EUROPEAN SURGICAL RESEARCH},
  language     = {eng},
  number       = {4},
  pages        = {346--352},
  title        = {Evaluation of Acellular Dermis for Closure of Abdominal Wall Defects in a Rat Model},
  url          = {http://dx.doi.org/10.1159/000161079},
  volume       = {41},
  year         = {2008},
}

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