Ghent University Academic Bibliography

Advanced

Growth factor/peptide receptor imaging for the development of targeted therapy in oncology

Christophe Van De Wiele UGent, H Boersma, Rudi Dierckx UGent, Philippus Elsinga UGent, Bart De Spiegeleer UGent and A Van Waarde (2008) CURRENT PHARMACEUTICAL DESIGN. 14(31). p.3340-3347
abstract
Receptor imaging by means of positron emission tomography (PET) and single photon emission computerized tomography (SPECT) may non-invasively address questions that are essential to the development and the clinical application of drugs targeting receptors expressed on human malignancies : is the receptor targeting drug getting to the tumor in the required concentration, is there a heterogeneity in tumor uptake, how fast is the drug cleared from the tumor and how is the receptor targeting drug metabolized. Such information may be used to assess the efficacy of strategies that aim to improve drug penetration through tumor tissue or to select compounds based on their ability to penetrate tumor tissue, thereby increasing the therapeutic index. In addition, imaging by means of PET and SPECT with receptor targeting radiopharmaceuticals may allow for the selection of patients that may benefit from receptor targeting therapies either ab initio, in the situation where the levels of receptor expression are proportional to the level of signaling via the receptor, or through sequential imaging in the situation where the level of receptor expression is not proportional to the level of signaling via the receptor and proof of down-regulation of the number of receptors is required.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
journal title
CURRENT PHARMACEUTICAL DESIGN
Curr. Pharm. Design
volume
14
issue
31
pages
3340 - 3347
Web of Science type
Review
Web of Science id
000261916100005
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
4.399 (2008)
JCR rank
29/216 (2008)
JCR quartile
1 (2008)
ISSN
1381-6128
language
English
UGent publication?
yes
classification
A1
id
517024
handle
http://hdl.handle.net/1854/LU-517024
date created
2009-03-11 10:18:11
date last changed
2010-04-29 15:23:34
@article{517024,
  abstract     = {Receptor imaging by means of positron emission tomography (PET) and single photon emission computerized tomography (SPECT) may non-invasively address questions that are essential to the development and the clinical application of drugs targeting receptors expressed on human malignancies : is the receptor targeting drug getting to the tumor in the required concentration, is there a heterogeneity in tumor uptake, how fast is the drug cleared from the tumor and how is the receptor targeting drug metabolized. Such information may be used to assess the efficacy of strategies that aim to improve drug penetration through tumor tissue or to select compounds based on their ability to penetrate tumor tissue, thereby increasing the therapeutic index.
In addition, imaging by means of PET and SPECT with receptor targeting radiopharmaceuticals may allow for the selection of patients that may benefit from receptor targeting therapies either ab initio, in the situation where the levels of receptor expression are proportional to the level of signaling via the receptor, or through sequential imaging in the situation where the level of receptor expression is not proportional to the level of signaling via the receptor and proof of down-regulation of the number of receptors is required.},
  author       = {Van De Wiele, Christophe and Boersma, H and Dierckx, Rudi and Elsinga, Philippus and De Spiegeleer, Bart and Van Waarde, A},
  issn         = {1381-6128},
  journal      = {CURRENT PHARMACEUTICAL DESIGN},
  language     = {eng},
  number       = {31},
  pages        = {3340--3347},
  title        = {Growth factor/peptide receptor imaging for the development of targeted therapy in oncology},
  volume       = {14},
  year         = {2008},
}

Chicago
Van De Wiele, Christophe, H Boersma, Rudi Dierckx, Philippus Elsinga, Bart De Spiegeleer, and A Van Waarde. 2008. “Growth Factor/peptide Receptor Imaging for the Development of Targeted Therapy in Oncology.” Current Pharmaceutical Design 14 (31): 3340–3347.
APA
Van De Wiele, Christophe, Boersma, H., Dierckx, R., Elsinga, P., De Spiegeleer, B., & Van Waarde, A. (2008). Growth factor/peptide receptor imaging for the development of targeted therapy in oncology. CURRENT PHARMACEUTICAL DESIGN, 14(31), 3340–3347.
Vancouver
1.
Van De Wiele C, Boersma H, Dierckx R, Elsinga P, De Spiegeleer B, Van Waarde A. Growth factor/peptide receptor imaging for the development of targeted therapy in oncology. CURRENT PHARMACEUTICAL DESIGN. 2008;14(31):3340–7.
MLA
Van De Wiele, Christophe, H Boersma, Rudi Dierckx, et al. “Growth Factor/peptide Receptor Imaging for the Development of Targeted Therapy in Oncology.” CURRENT PHARMACEUTICAL DESIGN 14.31 (2008): 3340–3347. Print.