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Prognostic value of FDG uptake by the bone marrow in squamous cell carcinoma of the head and neck

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Abstract
Background The appearance of natural suppressor cells and circulating endothelial progenitor cells in tumour tissue has been associated with myelopoetic stimulation by growth factors that may increase fluorodeoxyglucose (FDG) uptake by the bone marrow and high FDG uptake by bone marrow in patients suffering from human malignancies is a not uncommon finding. Methods This study looked at the relationship between bone marrow FDG uptake, biochemical (Hb level, RBC count, WBC count and platelet count), clinical and radiological findings and outcome in a series of 35 patients suffering from squamous cell carcinoma of the head and neck (SCCHN), consecutively referred for FDG PET as part of their routine staging procedure. Results and conclusion In SCCHN, mean FDG standardized uptake values (SUVs) of the primary tumour correlate significantly with blood WBC count (r=0.44; P=0.011, Bonferroni corrected P=0.04) and mean FDG SUVs of bone marrow are significantly correlated to the maximum FDG SUVs of the primary tumour (r=0.523; P=0.002). Finally, FDG uptake by the bone marrow is related to disease-free and overall survival. These findings warrant confirmation in a larger patient series.

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Chicago
Cicone, F, DAVID LOOSE, Philippe Deron, Hubert Vermeersch, A Signore, Frederic Van de Vyvere, F Scopinaro, and Christophe Van De Wiele. 2008. “Prognostic Value of FDG Uptake by the Bone Marrow in Squamous Cell Carcinoma of the Head and Neck.” Nuclear Medicine Communications 29 (5): 431–435.
APA
Cicone, F., LOOSE, D., Deron, P., Vermeersch, H., Signore, A., Van de Vyvere, F., Scopinaro, F., et al. (2008). Prognostic value of FDG uptake by the bone marrow in squamous cell carcinoma of the head and neck. Nuclear Medicine Communications, 29(5), 431–435.
Vancouver
1.
Cicone F, LOOSE D, Deron P, Vermeersch H, Signore A, Van de Vyvere F, et al. Prognostic value of FDG uptake by the bone marrow in squamous cell carcinoma of the head and neck. Nuclear Medicine Communications. 2008;29(5):431–5.
MLA
Cicone, F, DAVID LOOSE, Philippe Deron, et al. “Prognostic Value of FDG Uptake by the Bone Marrow in Squamous Cell Carcinoma of the Head and Neck.” Nuclear Medicine Communications 29.5 (2008): 431–435. Print.
@article{516996,
  abstract     = {Background The appearance of natural suppressor cells and circulating endothelial progenitor cells in tumour tissue has been associated with myelopoetic stimulation by growth factors that may increase fluorodeoxyglucose (FDG) uptake by the bone marrow and high FDG uptake by bone marrow in patients suffering from human malignancies is a not uncommon finding.
Methods This study looked at the relationship between bone marrow FDG uptake, biochemical (Hb level, RBC count, WBC count and platelet count), clinical and radiological findings and outcome in a series of 35 patients suffering from squamous cell carcinoma of the head and neck (SCCHN), consecutively referred for FDG PET as part of their routine staging procedure.

Results and conclusion In SCCHN, mean FDG standardized uptake values (SUVs) of the primary tumour correlate significantly with blood WBC count (r=0.44; P=0.011, Bonferroni corrected P=0.04) and mean FDG SUVs of bone marrow are significantly correlated to the maximum FDG SUVs of the primary tumour (r=0.523; P=0.002). Finally, FDG uptake by the bone marrow is related to disease-free and overall survival. These findings warrant confirmation in a larger patient series.},
  author       = {Cicone, F and LOOSE, DAVID and Deron, Philippe and Vermeersch, Hubert and Signore, A and Van de Vyvere, Frederic and Scopinaro, F and Van De Wiele, Christophe},
  issn         = {0143-3636},
  journal      = {Nuclear Medicine Communications},
  language     = {eng},
  number       = {5},
  pages        = {431--435},
  title        = {Prognostic value of FDG uptake by the bone marrow in squamous cell carcinoma of the head and neck},
  volume       = {29},
  year         = {2008},
}

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