Brain activation associated with deep brain stimulation causing dissociation in a patient with Tourette's syndrome
- Author
- Ingeborg Goethals (UGent) , Filip Jacobs (UGent) , Chris Van Der Linden, Jacques Caemaert (UGent) and Kurt Audenaert (UGent)
- Organization
- Abstract
- Dissociation involves a disruption in the integrated functions of consciousness, memory, identity, or perception of the environment. Attempts at localizing dissociative responses have yielded contradictory results regarding brain activation, laterality, and regional involvement. Here, we used a single-day split-dose activation paradigm with single photon emission computed tomography and 99m-Tc ethylcysteinatedimer as a brain perfusion tracer in a patient with Tourette's syndrome undergoing bilateral high-frequency thalamic stimulation for the treatment of tics who developed an alternate personality state during right thalamic stimulation. We documented increased regional cerebral blood flow in bilateral prefrontal and left temporal brain areas during the alternate identity state. We conclude that our findings support the temporal lobe as well as the frontolimbic disconnection hypotheses of dissociation.
- Keywords
- issociation, brain perfusion, deep brain stimulation, Tourette's syndrome
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-516921
- MLA
- Goethals, Ingeborg, et al. “Brain Activation Associated with Deep Brain Stimulation Causing Dissociation in a Patient with Tourette’s Syndrome.” JOURNAL OF TRAUMA & DISSOCIATION, vol. 9, no. 4, 2008, pp. 543–49, doi:10.1080/15299730802226126.
- APA
- Goethals, I., Jacobs, F., Van Der Linden, C., Caemaert, J., & Audenaert, K. (2008). Brain activation associated with deep brain stimulation causing dissociation in a patient with Tourette’s syndrome. JOURNAL OF TRAUMA & DISSOCIATION, 9(4), 543–549. https://doi.org/10.1080/15299730802226126
- Chicago author-date
- Goethals, Ingeborg, Filip Jacobs, Chris Van Der Linden, Jacques Caemaert, and Kurt Audenaert. 2008. “Brain Activation Associated with Deep Brain Stimulation Causing Dissociation in a Patient with Tourette’s Syndrome.” JOURNAL OF TRAUMA & DISSOCIATION 9 (4): 543–49. https://doi.org/10.1080/15299730802226126.
- Chicago author-date (all authors)
- Goethals, Ingeborg, Filip Jacobs, Chris Van Der Linden, Jacques Caemaert, and Kurt Audenaert. 2008. “Brain Activation Associated with Deep Brain Stimulation Causing Dissociation in a Patient with Tourette’s Syndrome.” JOURNAL OF TRAUMA & DISSOCIATION 9 (4): 543–549. doi:10.1080/15299730802226126.
- Vancouver
- 1.Goethals I, Jacobs F, Van Der Linden C, Caemaert J, Audenaert K. Brain activation associated with deep brain stimulation causing dissociation in a patient with Tourette’s syndrome. JOURNAL OF TRAUMA & DISSOCIATION. 2008;9(4):543–9.
- IEEE
- [1]I. Goethals, F. Jacobs, C. Van Der Linden, J. Caemaert, and K. Audenaert, “Brain activation associated with deep brain stimulation causing dissociation in a patient with Tourette’s syndrome,” JOURNAL OF TRAUMA & DISSOCIATION, vol. 9, no. 4, pp. 543–549, 2008.
@article{516921,
abstract = {{Dissociation involves a disruption in the integrated functions of consciousness, memory, identity, or perception of the environment. Attempts at localizing dissociative responses have yielded contradictory results regarding brain activation, laterality, and regional involvement. Here, we used a single-day split-dose activation paradigm with single photon emission computed tomography and 99m-Tc ethylcysteinatedimer as a brain perfusion tracer in a patient with Tourette's syndrome undergoing bilateral high-frequency thalamic stimulation for the treatment of tics who developed an alternate personality state during right thalamic stimulation. We documented increased regional cerebral blood flow in bilateral prefrontal and left temporal brain areas during the alternate identity state. We conclude that our findings support the temporal lobe as well as the frontolimbic disconnection hypotheses of dissociation.}},
author = {{Goethals, Ingeborg and Jacobs, Filip and Van Der Linden, Chris and Caemaert, Jacques and Audenaert, Kurt}},
issn = {{1529-9732}},
journal = {{JOURNAL OF TRAUMA & DISSOCIATION}},
keywords = {{issociation,brain perfusion,deep brain stimulation,Tourette's syndrome}},
language = {{eng}},
number = {{4}},
pages = {{543--549}},
title = {{Brain activation associated with deep brain stimulation causing dissociation in a patient with Tourette's syndrome}},
url = {{http://dx.doi.org/10.1080/15299730802226126}},
volume = {{9}},
year = {{2008}},
}
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