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Gastrin releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry

Christophe Van De Wiele UGent, Philippe Fonteyne UGent, Patrick Pauwels UGent, Ingeborg Goethals UGent, Rudy Van den Broecke UGent, Veronique Cocquyt UGent and Rudi Dierckx UGent (2008) JOURNAL OF NUCLEAR MEDICINE. 49(2). p.260-264
abstract
This study reports on the uptake of Tc-99m-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRIP-R) expression as measured by immunohistochemistry (IHC). Methods: Nine patients referred because of a clinical diagnosis suggestive of breast carcinoma and 5 patients with tamoxifen-resistant be-m breast carcinoma underwent 99mTc-RP527 scintigraphy. The findings were compared with routine staging examinations in all patients and with routine histology and IHC GRP-R staining in the first 9 patients. All 9 patients with suspected breast lesions were tumor positive. Results: The uptake of Tc-99m-RP527 was evident in the primary tumor in 8 of 9 patients and in involved lymph nodes and part of the distant metastasis limited to the bone when present. Tc-99m-RP527 uptake was not found in any of the tamoxifen-resistant patients. Conclusion: Uptake by primary breast carcinoma was significantly correlated with the presence of GRP-Rs as assessed by means of IHC.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
JOURNAL OF NUCLEAR MEDICINE
J. Nucl. Med.
volume
49
issue
2
pages
260 - 264
Web of Science type
Article
Web of Science id
000252866300034
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
6.662 (2008)
JCR rank
2/90 (2008)
JCR quartile
1 (2008)
ISSN
0161-5505
DOI
10.2967/jnumed.107.047167
language
English
UGent publication?
yes
classification
A1
id
516866
handle
http://hdl.handle.net/1854/LU-516866
date created
2009-03-11 09:28:10
date last changed
2009-10-08 16:53:42
@article{516866,
  abstract     = {This study reports on the uptake of Tc-99m-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRIP-R) expression as measured by immunohistochemistry (IHC). Methods: Nine patients referred because of a clinical diagnosis suggestive of breast carcinoma and 5 patients with tamoxifen-resistant be-m breast carcinoma underwent 99mTc-RP527 scintigraphy. The findings were compared with routine staging examinations in all patients and with routine histology and IHC GRP-R staining in the first 9 patients. All 9 patients with suspected breast lesions were tumor positive. Results: The uptake of Tc-99m-RP527 was evident in the primary tumor in 8 of 9 patients and in involved lymph nodes and part of the distant metastasis limited to the bone when present. Tc-99m-RP527 uptake was not found in any of the tamoxifen-resistant patients. Conclusion: Uptake by primary breast carcinoma was significantly correlated with the presence of GRP-Rs as assessed by means of IHC.},
  author       = {Van De Wiele, Christophe and Fonteyne, Philippe and Pauwels, Patrick and Goethals, Ingeborg and Van den Broecke, Rudy and Cocquyt, Veronique and Dierckx, Rudi},
  issn         = {0161-5505},
  journal      = {JOURNAL OF NUCLEAR MEDICINE},
  language     = {eng},
  number       = {2},
  pages        = {260--264},
  title        = {Gastrin releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry},
  url          = {http://dx.doi.org/10.2967/jnumed.107.047167},
  volume       = {49},
  year         = {2008},
}

Chicago
Van De Wiele, Christophe, Philippe Fonteyne, Patrick Pauwels, Ingeborg Goethals, Rudy Van den Broecke, Veronique Cocquyt, and Rudi Dierckx. 2008. “Gastrin Releasing Peptide Receptor Imaging in Human Breast Carcinoma Versus Immunohistochemistry.” Journal of Nuclear Medicine 49 (2): 260–264.
APA
Van De Wiele, Christophe, Fonteyne, P., Pauwels, P., Goethals, I., Van den Broecke, R., Cocquyt, V., & Dierckx, R. (2008). Gastrin releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry. JOURNAL OF NUCLEAR MEDICINE, 49(2), 260–264.
Vancouver
1.
Van De Wiele C, Fonteyne P, Pauwels P, Goethals I, Van den Broecke R, Cocquyt V, et al. Gastrin releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry. JOURNAL OF NUCLEAR MEDICINE. 2008;49(2):260–4.
MLA
Van De Wiele, Christophe, Philippe Fonteyne, Patrick Pauwels, et al. “Gastrin Releasing Peptide Receptor Imaging in Human Breast Carcinoma Versus Immunohistochemistry.” JOURNAL OF NUCLEAR MEDICINE 49.2 (2008): 260–264. Print.