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Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus

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Abstract
Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies ( ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE). Methods: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae. Results: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement. Conclusion: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.

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Chicago
Hoffman, IEA, BR Lauwerys, Filip De Keyser, TWJ Huizinga, D Isenberg, L Cebecauer, Joke Dehoorne, et al. 2009. “Juvenile-onset Systemic Lupus Erythematosus: Different Clinical and Serological Pattern Than Adult-onset Systemic Lupus Erythematosus.” Annals of the Rheumatic Diseases 68 (3): 412–415.
APA
Hoffman, IEA, Lauwerys, B., De Keyser, F., Huizinga, T., Isenberg, D., Cebecauer, L., Dehoorne, J., et al. (2009). Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Annals of the Rheumatic Diseases, 68(3), 412–415.
Vancouver
1.
Hoffman I, Lauwerys B, De Keyser F, Huizinga T, Isenberg D, Cebecauer L, et al. Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Annals of the Rheumatic Diseases. England: BMJ Publishing group; 2009;68(3):412–5.
MLA
Hoffman, IEA, BR Lauwerys, Filip De Keyser, et al. “Juvenile-onset Systemic Lupus Erythematosus: Different Clinical and Serological Pattern Than Adult-onset Systemic Lupus Erythematosus.” Annals of the Rheumatic Diseases 68.3 (2009): 412–415. Print.
@article{516261,
  abstract     = {Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies ( ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE).
Methods: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae.

Results: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement.

Conclusion: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.},
  author       = {Hoffman, IEA and Lauwerys, BR and De Keyser, Filip and Huizinga, TWJ and Isenberg, D and Cebecauer, L and Dehoorne, Joke and Joos, Rik and Hendrickx, G and Houssiau, F and Elewaut, Dirk},
  issn         = {0003-4967},
  journal      = {Annals of the Rheumatic Diseases},
  language     = {eng},
  number       = {3},
  pages        = {412--415},
  publisher    = {BMJ Publishing group},
  title        = {Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1136/ard.2008.094813},
  volume       = {68},
  year         = {2009},
}

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