Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus
- Author
- IEA Hoffman, BR Lauwerys, Filip De Keyser (UGent) , TWJ Huizinga, D Isenberg, L Cebecauer, Joke Dehoorne, Rik Joos, G Hendrickx, F Houssiau and Dirk Elewaut (UGent)
- Organization
- Abstract
- Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies ( ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE). Methods: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae. Results: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement. Conclusion: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-516261
- MLA
- Hoffman, IEA, et al. “Juvenile-Onset Systemic Lupus Erythematosus: Different Clinical and Serological Pattern than Adult-Onset Systemic Lupus Erythematosus.” Annals of the Rheumatic Diseases, vol. 68, no. 3, BMJ Publishing group, 2009, pp. 412–15, doi:10.1136/ard.2008.094813.
- APA
- Hoffman, I., Lauwerys, B., De Keyser, F., Huizinga, T., Isenberg, D., Cebecauer, L., … Elewaut, D. (2009). Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Annals of the Rheumatic Diseases, 68(3), 412–415. https://doi.org/10.1136/ard.2008.094813
- Chicago author-date
- Hoffman, IEA, BR Lauwerys, Filip De Keyser, TWJ Huizinga, D Isenberg, L Cebecauer, Joke Dehoorne, et al. 2009. “Juvenile-Onset Systemic Lupus Erythematosus: Different Clinical and Serological Pattern than Adult-Onset Systemic Lupus Erythematosus.” Annals of the Rheumatic Diseases 68 (3): 412–15. https://doi.org/10.1136/ard.2008.094813.
- Chicago author-date (all authors)
- Hoffman, IEA, BR Lauwerys, Filip De Keyser, TWJ Huizinga, D Isenberg, L Cebecauer, Joke Dehoorne, Rik Joos, G Hendrickx, F Houssiau, and Dirk Elewaut. 2009. “Juvenile-Onset Systemic Lupus Erythematosus: Different Clinical and Serological Pattern than Adult-Onset Systemic Lupus Erythematosus.” Annals of the Rheumatic Diseases 68 (3): 412–415. doi:10.1136/ard.2008.094813.
- Vancouver
- 1.Hoffman I, Lauwerys B, De Keyser F, Huizinga T, Isenberg D, Cebecauer L, et al. Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Annals of the Rheumatic Diseases. 2009;68(3):412–5.
- IEEE
- [1]I. Hoffman et al., “Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus,” Annals of the Rheumatic Diseases, vol. 68, no. 3, pp. 412–415, 2009.
@article{516261, abstract = {{Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies ( ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE). Methods: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae. Results: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement. Conclusion: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.}}, author = {{Hoffman, IEA and Lauwerys, BR and De Keyser, Filip and Huizinga, TWJ and Isenberg, D and Cebecauer, L and Dehoorne, Joke and Joos, Rik and Hendrickx, G and Houssiau, F and Elewaut, Dirk}}, issn = {{0003-4967}}, journal = {{Annals of the Rheumatic Diseases}}, language = {{eng}}, number = {{3}}, pages = {{412--415}}, publisher = {{BMJ Publishing group}}, title = {{Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus}}, url = {{http://doi.org/10.1136/ard.2008.094813}}, volume = {{68}}, year = {{2009}}, }
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