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Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus

Hoffman, IEA, Lauwerys, BR, De Keyser, Filip UGent, Huizinga, TWJ, Isenberg, D, Cebecauer, L, Dehoorne, Joke, Joos, Rik, Hendrickx, G, Houssiau, F, et al. (2009) Annals of the Rheumatic Diseases. 68(3). p.412-415
abstract
Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies ( ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE). Methods: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae. Results: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement. Conclusion: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
Annals of the Rheumatic Diseases
Ann. Rheum. Dis.
volume
68
issue
3
pages
412 - 415
publisher
BMJ Publishing group
place of publication
England
Web of Science type
Article
Web of Science id
000263318200022
JCR category
RHEUMATOLOGY
JCR impact factor
8.111 (2009)
JCR rank
1/24 (2009)
JCR quartile
1 (2009)
ISSN
0003-4967
DOI
10.1136/ard.2008.094813
language
English
UGent publication?
yes
classification
A1
id
516261
handle
http://hdl.handle.net/1854/LU-516261
date created
2009-03-10 10:15:40
date last changed
2017-01-02 09:55:24
@article{516261,
  abstract     = {Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies ( ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE).
Methods: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae.

Results: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement.

Conclusion: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.},
  author       = {Hoffman, IEA and Lauwerys, BR and De Keyser, Filip and Huizinga, TWJ and Isenberg, D and Cebecauer, L and Dehoorne, Joke and Joos, Rik and Hendrickx, G and Houssiau, F and Elewaut, Dirk},
  issn         = {0003-4967},
  journal      = {Annals of the Rheumatic Diseases},
  language     = {eng},
  number       = {3},
  pages        = {412--415},
  publisher    = {BMJ Publishing group},
  title        = {Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1136/ard.2008.094813},
  volume       = {68},
  year         = {2009},
}

Chicago
Hoffman, IEA, BR Lauwerys, Filip De Keyser, TWJ Huizinga, D Isenberg, L Cebecauer, Joke Dehoorne, et al. 2009. “Juvenile-onset Systemic Lupus Erythematosus: Different Clinical and Serological Pattern Than Adult-onset Systemic Lupus Erythematosus.” Annals of the Rheumatic Diseases 68 (3): 412–415.
APA
Hoffman, IEA, Lauwerys, B., De Keyser, F., Huizinga, T., Isenberg, D., Cebecauer, L., Dehoorne, J., et al. (2009). Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Annals of the Rheumatic Diseases, 68(3), 412–415.
Vancouver
1.
Hoffman I, Lauwerys B, De Keyser F, Huizinga T, Isenberg D, Cebecauer L, et al. Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus. Annals of the Rheumatic Diseases. England: BMJ Publishing group; 2009;68(3):412–5.
MLA
Hoffman, IEA, BR Lauwerys, Filip De Keyser, et al. “Juvenile-onset Systemic Lupus Erythematosus: Different Clinical and Serological Pattern Than Adult-onset Systemic Lupus Erythematosus.” Annals of the Rheumatic Diseases 68.3 (2009): 412–415. Print.