Ghent University Academic Bibliography

Advanced

New strategies for nucleic acid delivery to conquer cellular and nuclear membranes

Ine Lentacker UGent, Roosmarijn Vandenbroucke UGent, Bart Lucas UGent, Jo Demeester UGent, Stefaan De Smedt UGent and Niek Sanders UGent (2008) Journal of Controlled Release. 132(3). p.279-288
abstract
After administration to the body, nucleic acid containing nanoparticles (NANs) need to cross several extra- and intracellular barriers to reach the cytoplasm or nucleus of the target cells. In the last decade several groups tried to overcome these barriers by arming non-viral delivery systems with targeting moieties, polyethylene glycol chains, fusogenic peptides and so forth. However, the drawback of this upgrading strategy is that each of the encountered barriers requires a new functionality, leading to very complex multicomponent NANs. Moreover, there are currently no components available that can efficiently transport genes or NANs inside the nucleus of non-dividing cells. In this article a new, ultrasound based delivery system that possesses the capacity to simultaneously overcome several key barriers in non-viral nucleic acid delivery is presented. Additionally, a small amphiphilic compound that induces nuclear uptake of plasmid DNA and enhances non-viral gene transfer is presented.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Microbubbles, Ultrasound, Liposomes, Nuclear entry, ULTRASOUND-MEDIATED TRANSFECTION, PLASMID-LIPID PARTICLES, GENE-THERAPY PROGRESS, INTRACELLULAR DELIVERY, Gene delivery, LOADED MICROBUBBLES, ALBUMIN MICROBUBBLES, CATIONIC LIPOSOMES, SYSTEMIC DELIVERY, IN-VITRO, DNA
journal title
Journal of Controlled Release
J. Control. Release
editor
J Feijen, WE Hennink and AP Sam
volume
132
issue
3
issue title
Proceedings of the Tenth European Symposium on Controlled Drug Delivery
pages
279 - 288
publisher
Elsevier
place of publication
Amsterdam
conference name
Tenth European Symposium on Controlled Drug Delivery
conference location
Noordwijk aan Zee
conference start
2008-04-02
conference end
2008-04-04
Web of Science type
Article
Web of Science id
000261902800019
JCR category
CHEMISTRY, MULTIDISCIPLINARY
JCR impact factor
5.69 (2008)
JCR rank
10/125 (2008)
JCR quartile
1 (2008)
ISSN
0168-3659
DOI
10.1016/j.jconrel.2008.06.023
language
English
UGent publication?
yes
classification
A1
id
514114
handle
http://hdl.handle.net/1854/LU-514114
date created
2009-03-04 13:28:03
date last changed
2009-03-04 14:54:12
@article{514114,
  abstract     = {After administration to the body, nucleic acid containing nanoparticles (NANs) need to cross several extra- and intracellular barriers to reach the cytoplasm or nucleus of the target cells. In the last decade several groups tried to overcome these barriers by arming non-viral delivery systems with targeting moieties, polyethylene glycol chains, fusogenic peptides and so forth. However, the drawback of this upgrading strategy is that each of the encountered barriers requires a new functionality, leading to very complex multicomponent NANs. Moreover, there are currently no components available that can efficiently transport genes or NANs inside the nucleus of non-dividing cells. In this article a new, ultrasound based delivery system that possesses the capacity to simultaneously overcome several key barriers in non-viral nucleic acid delivery is presented. Additionally, a small amphiphilic compound that induces nuclear uptake of plasmid DNA and enhances non-viral gene transfer is presented.},
  author       = {Lentacker, Ine and Vandenbroucke, Roosmarijn and Lucas, Bart and Demeester, Jo and De Smedt, Stefaan and Sanders, Niek},
  editor       = {Feijen, J and Hennink, WE and Sam, AP},
  issn         = {0168-3659},
  journal      = {Journal of Controlled Release},
  keyword      = {Microbubbles,Ultrasound,Liposomes,Nuclear entry,ULTRASOUND-MEDIATED TRANSFECTION,PLASMID-LIPID PARTICLES,GENE-THERAPY PROGRESS,INTRACELLULAR DELIVERY,Gene delivery,LOADED MICROBUBBLES,ALBUMIN MICROBUBBLES,CATIONIC LIPOSOMES,SYSTEMIC DELIVERY,IN-VITRO,DNA},
  language     = {eng},
  location     = {Noordwijk aan Zee},
  number       = {3},
  pages        = {279--288},
  publisher    = {Elsevier},
  title        = {New strategies for nucleic acid delivery to conquer cellular and nuclear membranes},
  url          = {http://dx.doi.org/10.1016/j.jconrel.2008.06.023},
  volume       = {132},
  year         = {2008},
}

Chicago
Lentacker, Ine, Roosmarijn Vandenbroucke, Bart Lucas, Jo Demeester, Stefaan De Smedt, and Niek Sanders. 2008. “New Strategies for Nucleic Acid Delivery to Conquer Cellular and Nuclear Membranes.” Ed. J Feijen, WE Hennink, and AP Sam. Journal of Controlled Release 132 (3): 279–288.
APA
Lentacker, I., Vandenbroucke, R., Lucas, B., Demeester, J., De Smedt, S., & Sanders, N. (2008). New strategies for nucleic acid delivery to conquer cellular and nuclear membranes. (J. Feijen, W. Hennink, & A. Sam, Eds.)Journal of Controlled Release, 132(3), 279–288. Presented at the Tenth European Symposium on Controlled Drug Delivery.
Vancouver
1.
Lentacker I, Vandenbroucke R, Lucas B, Demeester J, De Smedt S, Sanders N. New strategies for nucleic acid delivery to conquer cellular and nuclear membranes. Feijen J, Hennink W, Sam A, editors. Journal of Controlled Release. Amsterdam: Elsevier; 2008;132(3):279–88.
MLA
Lentacker, Ine, Roosmarijn Vandenbroucke, Bart Lucas, et al. “New Strategies for Nucleic Acid Delivery to Conquer Cellular and Nuclear Membranes.” Ed. J Feijen, WE Hennink, & AP Sam. Journal of Controlled Release 132.3 (2008): 279–288. Print.