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The design of anisotropic diffusion phantoms for the validation of diffusion weighted magnetic resonance imaging

Els Fieremans, Yves De Deene UGent, Steven Delputte, Mahir Ozdemir UGent, Eric Achten UGent and Ignace Lemahieu UGent (2008) PHYSICS IN MEDICINE AND BIOLOGY. 53(19). p.5405-5419
abstract
Diffusion weighted magnetic resonance imaging offers a non-invasive tool to explore the three-dimensional structure of brain white matter in clinical practice. Anisotropic diffusion hardware phantoms are useful for the quantitative validation of this technique. This study provides guidelines on how to manufacture anisotropic fibre phantoms in a reproducible way and which fibre material to choose to obtain a good quality of the diffusion weighted images. Several fibre materials are compared regarding their effect on the diffusion MR measurements of the water molecules inside the phantoms. The diffusion anisotropy influencing material properties are the fibre density and diameter, while the fibre surface relaxivity and magnetic susceptibility determine the signal-to-noise ratio. The effect on the T2-relaxation time of water in the phantoms has been modelled and the diffusion behaviour inside the fibre phantoms has been quantitatively evaluated using Monte Carlo random walk simulations.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
PHYSICS IN MEDICINE AND BIOLOGY
Phys. Med. Biol.
volume
53
issue
19
pages
5405 - 5419
Web of Science type
Article
Web of Science id
000259116100010
JCR category
ENGINEERING, BIOMEDICAL
JCR impact factor
2.784 (2008)
JCR rank
10/51 (2008)
JCR quartile
1 (2008)
ISSN
0031-9155
DOI
10.1088/0031-9155/53/19/009
language
English
UGent publication?
yes
classification
A1
id
513818
handle
http://hdl.handle.net/1854/LU-513818
date created
2009-03-03 20:40:21
date last changed
2009-03-04 14:07:34
@article{513818,
  abstract     = {Diffusion weighted magnetic resonance imaging offers a non-invasive tool to explore the three-dimensional structure of brain white matter in clinical practice. Anisotropic diffusion hardware phantoms are useful for the quantitative validation of this technique. This study provides guidelines on how to manufacture anisotropic fibre phantoms in a reproducible way and which fibre material to choose to obtain a good quality of the diffusion weighted images. Several fibre materials are compared regarding their effect on the diffusion MR measurements of the water molecules inside the phantoms. The diffusion anisotropy influencing material properties are the fibre density and diameter, while the fibre surface relaxivity and magnetic susceptibility determine the signal-to-noise ratio. The effect on the T2-relaxation time of water in the phantoms has been modelled and the diffusion behaviour inside the fibre phantoms has been quantitatively evaluated using Monte Carlo random walk simulations.},
  author       = {Fieremans, Els and De Deene, Yves and Delputte, Steven and Ozdemir, Mahir and Achten, Eric and Lemahieu, Ignace},
  issn         = {0031-9155},
  journal      = {PHYSICS IN MEDICINE AND BIOLOGY},
  language     = {eng},
  number       = {19},
  pages        = {5405--5419},
  title        = {The design of anisotropic diffusion phantoms for the validation of diffusion weighted magnetic resonance imaging},
  url          = {http://dx.doi.org/10.1088/0031-9155/53/19/009},
  volume       = {53},
  year         = {2008},
}

Chicago
Fieremans, Els, Yves De Deene, Steven Delputte, Mahir Ozdemir, Eric Achten, and Ignace Lemahieu. 2008. “The Design of Anisotropic Diffusion Phantoms for the Validation of Diffusion Weighted Magnetic Resonance Imaging.” Physics in Medicine and Biology 53 (19): 5405–5419.
APA
Fieremans, E., De Deene, Y., Delputte, S., Ozdemir, M., Achten, E., & Lemahieu, I. (2008). The design of anisotropic diffusion phantoms for the validation of diffusion weighted magnetic resonance imaging. PHYSICS IN MEDICINE AND BIOLOGY, 53(19), 5405–5419.
Vancouver
1.
Fieremans E, De Deene Y, Delputte S, Ozdemir M, Achten E, Lemahieu I. The design of anisotropic diffusion phantoms for the validation of diffusion weighted magnetic resonance imaging. PHYSICS IN MEDICINE AND BIOLOGY. 2008;53(19):5405–19.
MLA
Fieremans, Els, Yves De Deene, Steven Delputte, et al. “The Design of Anisotropic Diffusion Phantoms for the Validation of Diffusion Weighted Magnetic Resonance Imaging.” PHYSICS IN MEDICINE AND BIOLOGY 53.19 (2008): 5405–5419. Print.