Ghent University Academic Bibliography

Advanced

Variation in deficient serum vitamin E levels and impact on assessment of the vitamin E status in horses

Katleen Vanschandevijl UGent, Heidi Nollet UGent, Piet Deprez UGent, Catherine Delesalle UGent, Laurence Lefère UGent, Jeroen Dewulf UGent and Gunther van Loon UGent (2009) VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 78(1). p.28-33
abstract
A large fluctuation in normal serum vitamin E (alpha-tocopherol) concentrations (> 2 mu g/ml) has been demonstrated in normal horses. The purpose of this study was to verify the fluctuation in serum vitamin E in horses with deficient levels (< 1.5 mu g/ml) and to assess the diagnostic value of a single serum sample to determine the vitamin E status in a deficient horse. Serum vitamin E levels were monitored over a period of 24 hours in 6 normal horses and in 22 horses with clinical signs that may be related to vitamin E deficiency. The serum vitamin E levels varied widely within each horse, and the coefficient of variation (CV) was significantly larger in the deficient horses (mean CV: 41%), compared to the horses with normal levels (mean CV: 14%). In a small proportion of the deficient horses, the vitamin E levels varied from deficient to normal within 24 hours. The sensitivity of a single sample compared to the "true value" determined by the average of the samples, was 91%. The sensitivity in case of 2 serum samples increased to 97%. These findings suggest that a single serum value does not always provide reliable information about the true vitamin E status in a deficient horse and analyzing 2 serum samples allows a more accurate estimation of the vitamin E status. The conclusion therefore is that when a serum vitamin E value > 1.5 mu g/ml is found in clinically suspected horses, a second serum sample should be evaluated.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ALPHA-TOCOPHEROL CONCENTRATIONS, MOTOR-NEURON DISEASE, DEGENERATIVE MYELOENCEPHALOPATHY, ADULT HORSES, FOALS, TISSUE, MARES, RISK
journal title
VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
Vlaams Diergeneeskund. Tijds.
editor
Aart de Kruif
volume
78
issue
1
pages
28 - 33
Web of Science type
Article
Web of Science id
000263790800002
JCR category
VETERINARY SCIENCES
JCR impact factor
0.179 (2009)
JCR rank
118/141 (2009)
JCR quartile
4 (2009)
ISSN
0303-9021
language
English
UGent publication?
yes
classification
A1
id
504879
handle
http://hdl.handle.net/1854/LU-504879
date created
2009-02-24 12:28:15
date last changed
2009-04-03 17:25:48
@article{504879,
  abstract     = {A large fluctuation in normal serum vitamin E (alpha-tocopherol) concentrations ({\textrangle} 2 mu g/ml) has been demonstrated in normal horses. The purpose of this study was to verify the fluctuation in serum vitamin E in horses with deficient levels ({\textlangle} 1.5 mu g/ml) and to assess the diagnostic value of a single serum sample to determine the vitamin E status in a deficient horse. Serum vitamin E levels were monitored over a period of 24 hours in 6 normal horses and in 22 horses with clinical signs that may be related to vitamin E deficiency. The serum vitamin E levels varied widely within each horse, and the coefficient of variation (CV) was significantly larger in the deficient horses (mean CV: 41\%), compared to the horses with normal levels (mean CV: 14\%). In a small proportion of the deficient horses, the vitamin E levels varied from deficient to normal within 24 hours. The sensitivity of a single sample compared to the {\textacutedbl}true value{\textacutedbl} determined by the average of the samples, was 91\%. The sensitivity in case of 2 serum samples increased to 97\%. These findings suggest that a single serum value does not always provide reliable information about the true vitamin E status in a deficient horse and analyzing 2 serum samples allows a more accurate estimation of the vitamin E status. The conclusion therefore is that when a serum vitamin E value {\textrangle} 1.5 mu g/ml is found in clinically suspected horses, a second serum sample should be evaluated.},
  author       = {Vanschandevijl, Katleen and Nollet, Heidi and Deprez, Piet and Delesalle, Catherine and Lef{\`e}re, Laurence and Dewulf, Jeroen and van Loon, Gunther},
  editor       = {de Kruif, Aart},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {ALPHA-TOCOPHEROL CONCENTRATIONS,MOTOR-NEURON DISEASE,DEGENERATIVE MYELOENCEPHALOPATHY,ADULT HORSES,FOALS,TISSUE,MARES,RISK},
  language     = {eng},
  number       = {1},
  pages        = {28--33},
  title        = {Variation in deficient serum vitamin E levels and impact on assessment of the vitamin E status in horses},
  volume       = {78},
  year         = {2009},
}

Chicago
Vanschandevijl, Katleen, Heidi Nollet, Piet Deprez, Catherine Delesalle, Laurence Lefère, Jeroen Dewulf, and Gunther van Loon. 2009. “Variation in Deficient Serum Vitamin E Levels and Impact on Assessment of the Vitamin E Status in Horses.” Ed. Aart de Kruif. Vlaams Diergeneeskundig Tijdschrift 78 (1): 28–33.
APA
Vanschandevijl, K., Nollet, H., Deprez, P., Delesalle, C., Lefère, L., Dewulf, J., & van Loon, G. (2009). Variation in deficient serum vitamin E levels and impact on assessment of the vitamin E status in horses. (A. de Kruif, Ed.)VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 78(1), 28–33.
Vancouver
1.
Vanschandevijl K, Nollet H, Deprez P, Delesalle C, Lefère L, Dewulf J, et al. Variation in deficient serum vitamin E levels and impact on assessment of the vitamin E status in horses. de Kruif A, editor. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2009;78(1):28–33.
MLA
Vanschandevijl, Katleen, Heidi Nollet, Piet Deprez, et al. “Variation in Deficient Serum Vitamin E Levels and Impact on Assessment of the Vitamin E Status in Horses.” Ed. Aart de Kruif. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 78.1 (2009): 28–33. Print.