Ghent University Academic Bibliography

Advanced

Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Considerations for structural elucidation

Oscar Juan Pozo Mendoza UGent, Peter Van Eenoo UGent, Koen Deventer UGent, S Grimalt, JV Sancho, F Hernandez and Frans Delbeke UGent (2008) RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 22(24). p.4009-4024
abstract
Abstract: The collision-induced dissociation of forty-one 3-keto anabolic steroids and related compounds has been studied using both triple quadrupole (QqQ) and hybrid quadrupole-time of flight (QTOF) instruments. Due to the complexity of the product ion spectra of these analytes, which generate a large number of ions, only two specific regions were studied in depth: the product ions near the precursor ion (m/z >= M-100) and the most abundant product ions at a collision energy of 30eV. Accurate mass measurements were used in order to obtain an unequivocal assignment of the empirical formula and the origin of each selected product ion. Analytes have been divided into eight groups according to the number and position of double bonds and the presence of functional groups such as hydroxyl- or nitrogen-containing rings. A correlation between the steroid structure and the product ions obtained has been postulated. The application of these correlations can be useful in the elucidation of feasible structures for unknown steroids and/or their metabolites. Copyright (C) 2008 John Wiley & Sons, Ltd.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ION-TRAP, ANALOGS, LIQUID-CHROMATOGRAPHY, HUMAN URINE, DESIGNER STEROIDS, METABOLITES, STANOZOLOL, TANDEM MASS-SPECTROMETRY, IDENTIFICATION
journal title
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
RCM, Rapid commun. mass spectrom.
volume
22
issue
24
pages
4009 - 4024
Web of Science type
Article
Web of Science id
000262293100005
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
2.772 (2008)
JCR rank
16/70 (2008)
JCR quartile
1 (2008)
ISSN
0951-4198
DOI
10.1002/rcm.3823
language
English
UGent publication?
yes
classification
A1
id
495981
handle
http://hdl.handle.net/1854/LU-495981
date created
2009-02-17 08:53:45
date last changed
2009-05-04 14:07:37
@article{495981,
  abstract     = {Abstract: The collision-induced dissociation of forty-one 3-keto anabolic steroids and related compounds has been studied using both triple quadrupole (QqQ) and hybrid quadrupole-time of flight (QTOF) instruments. Due to the complexity of the product ion spectra of these analytes, which generate a large number of ions, only two specific regions were studied in depth: the product ions near the precursor ion (m/z {\textrangle}= M-100) and the most abundant product ions at a collision energy of 30eV. Accurate mass measurements were used in order to obtain an unequivocal assignment of the empirical formula and the origin of each selected product ion. Analytes have been divided into eight groups according to the number and position of double bonds and the presence of functional groups such as hydroxyl- or nitrogen-containing rings. A correlation between the steroid structure and the product ions obtained has been postulated. The application of these correlations can be useful in the elucidation of feasible structures for unknown steroids and/or their metabolites. Copyright (C) 2008 John Wiley \& Sons, Ltd.},
  author       = {Pozo Mendoza, Oscar Juan and Van Eenoo, Peter and Deventer, Koen and Grimalt, S and Sancho, JV and Hernandez, F and Delbeke, Frans},
  issn         = {0951-4198},
  journal      = {RAPID COMMUNICATIONS IN MASS SPECTROMETRY},
  keyword      = {ION-TRAP,ANALOGS,LIQUID-CHROMATOGRAPHY,HUMAN URINE,DESIGNER STEROIDS,METABOLITES,STANOZOLOL,TANDEM MASS-SPECTROMETRY,IDENTIFICATION},
  language     = {eng},
  number       = {24},
  pages        = {4009--4024},
  title        = {Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Considerations for structural elucidation},
  url          = {http://dx.doi.org/10.1002/rcm.3823},
  volume       = {22},
  year         = {2008},
}

Chicago
Pozo Mendoza, Oscar Juan, Peter Van Eenoo, Koen Deventer, S Grimalt, JV Sancho, F Hernandez, and Frans Delbeke. 2008. “Collision-induced Dissociation of 3-keto Anabolic Steroids and Related Compounds After Electrospray Ionization. Considerations for Structural Elucidation.” Rapid Communications in Mass Spectrometry 22 (24): 4009–4024.
APA
Pozo Mendoza, O. J., Van Eenoo, P., Deventer, K., Grimalt, S., Sancho, J., Hernandez, F., & Delbeke, F. (2008). Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Considerations for structural elucidation. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 22(24), 4009–4024.
Vancouver
1.
Pozo Mendoza OJ, Van Eenoo P, Deventer K, Grimalt S, Sancho J, Hernandez F, et al. Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Considerations for structural elucidation. RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 2008;22(24):4009–24.
MLA
Pozo Mendoza, Oscar Juan, Peter Van Eenoo, Koen Deventer, et al. “Collision-induced Dissociation of 3-keto Anabolic Steroids and Related Compounds After Electrospray Ionization. Considerations for Structural Elucidation.” RAPID COMMUNICATIONS IN MASS SPECTROMETRY 22.24 (2008): 4009–4024. Print.